Two faces of Schwann cell dedifferentiation in peripheral neurodegenerative diseases：pro-demyelinating and axon-preservative functions
Schwann cells are glial cells that are responsible for the synthesis and maintenance of the myelin sheath in the peripheral nerve system. Under pathological conditions, such as physical nerve injury and inflammatory neuropathies, Schwann cells undergo a substantial phenotype transformation that is n...
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| Veröffentlicht in: | Neural regeneration research 2014-11, Vol.9 (22), p.1952-1954 |
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| container_title | Neural regeneration research |
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| creator | Kim, Jong Kuk Lee, Hye Jeong Park, Hwan Tae |
| description | Schwann cells are glial cells that are responsible for the synthesis and maintenance of the myelin sheath in the peripheral nerve system. Under pathological conditions, such as physical nerve injury and inflammatory neuropathies, Schwann cells undergo a substantial phenotype transformation that is not related to their intended function. For example, Schwann cells dedifferentiate into immature states and thereby cease to express myelin genes after nerve injury. |
| doi_str_mv | 10.4103/1673-5374.145370 |
| format | Article |
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Under pathological conditions, such as physical nerve injury and inflammatory neuropathies, Schwann cells undergo a substantial phenotype transformation that is not related to their intended function. For example, Schwann cells dedifferentiate into immature states and thereby cease to express myelin genes after nerve injury.</description><identifier>ISSN: 1673-5374</identifier><identifier>EISSN: 1876-7958</identifier><identifier>DOI: 10.4103/1673-5374.145370</identifier><identifier>PMID: 25598775</identifier><language>eng</language><publisher>India: Medknow Publications and Media Pvt. Ltd</publisher><subject>Cell differentiation ; Defense mechanisms ; Degeneration ; Gene expression ; Kinases ; Nervous system ; Neurodegeneration ; Neurophysiology ; Peripheral neuropathy ; Physiological aspects ; Proteins ; Schwann cells ; Transcription factors ; 神经损伤 ; 神经胶质细胞 ; 神经退行性疾病 ; 细胞分化 ; 轴突 ; 防腐功能 ; 雪旺氏细胞 ; 髓鞘</subject><ispartof>Neural regeneration research, 2014-11, Vol.9 (22), p.1952-1954</ispartof><rights>COPYRIGHT 2014 Medknow Publications and Media Pvt. Ltd.</rights><rights>2014. This article is published under (http://creativecommons.org/licenses/by-nc-sa/3.0/) (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Copyright © Wanfang Data Co. Ltd. All Rights Reserved.</rights><rights>Copyright: © Neural Regeneration Research 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c554t-9d7347c9049864b2b4ed48b815a0eb9336e20fd86bedb3d7a67dd3b3d38b9b093</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/88507X/88507X.jpg</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4283275/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4283275/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,886,27929,27930,53796,53798</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25598775$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Jong Kuk</creatorcontrib><creatorcontrib>Lee, Hye Jeong</creatorcontrib><creatorcontrib>Park, Hwan Tae</creatorcontrib><title>Two faces of Schwann cell dedifferentiation in peripheral neurodegenerative diseases：pro-demyelinating and axon-preservative functions</title><title>Neural regeneration research</title><addtitle>Neural Regeneration Research</addtitle><description>Schwann cells are glial cells that are responsible for the synthesis and maintenance of the myelin sheath in the peripheral nerve system. Under pathological conditions, such as physical nerve injury and inflammatory neuropathies, Schwann cells undergo a substantial phenotype transformation that is not related to their intended function. For example, Schwann cells dedifferentiate into immature states and thereby cease to express myelin genes after nerve injury.</description><subject>Cell differentiation</subject><subject>Defense mechanisms</subject><subject>Degeneration</subject><subject>Gene expression</subject><subject>Kinases</subject><subject>Nervous system</subject><subject>Neurodegeneration</subject><subject>Neurophysiology</subject><subject>Peripheral neuropathy</subject><subject>Physiological aspects</subject><subject>Proteins</subject><subject>Schwann cells</subject><subject>Transcription factors</subject><subject>神经损伤</subject><subject>神经胶质细胞</subject><subject>神经退行性疾病</subject><subject>细胞分化</subject><subject>轴突</subject><subject>防腐功能</subject><subject>雪旺氏细胞</subject><subject>髓鞘</subject><issn>1673-5374</issn><issn>1876-7958</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNptUs1u1DAQjhCIlsKdE4rggoSy2LETOxekquJPqsSBcraceJz1Kmun9mbL9gl4Bp6Fd-IVmGi3K4qQD2N7vu-b8fjLsueULDgl7C2tBSsqJviCcgzkQXZKpagL0VTyIe7v0ifZk5RWhFSyKdnj7KSsqkYKUZ1mP65uQm51BykPNv_aLW-093kHw5AbMM5aiOA3Tm9c8Lnz-QjRjUuIesg9TDEY6MHjceO2kBuXQCdIv3_9HGMoDKx3MDiPSd_n2ptcfw--GCMkiNs9xU6-m7XT0-yR1UOCZ4d4ln378P7q4lNx-eXj54vzy6KrKr4pGiMYF11DeCNr3pYtB8NlK2mlCbQNYzWUxBpZt2BaZoSuhTEMd0y2TUsadpa92-uOU7sG0-Hr8DFqjG6t404F7dT9jHdL1Yet4qVkpahQ4M1eACdlte_VKkzRY8vqtk-r27RbKWyB8rIkhCH69aFcDNcTpI1auzSPV3sIU1K0rkpOak44Ql_9Az0ql0xi6Zrh7x1RvR5AOW8DdtnNouqcNVxyRtnc5OI_KFz4J64LHqzD-3sEsid0MaQUwR4nQomavaZmM6nZTGrvNaS8-HuSR8KduRDw8qC5DL6_RhMcMXWNNUXDKfsDFkTeUA</recordid><startdate>20141115</startdate><enddate>20141115</enddate><creator>Kim, Jong Kuk</creator><creator>Lee, Hye Jeong</creator><creator>Park, Hwan Tae</creator><general>Medknow Publications and Media Pvt. 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Ltd</general><general>Department of Neurology, Mitochondria Hub Regulation Center MHRC, College of Medicine, Dong-A University, Busan, South Korea%Department of Pharmacology, Mitochondria Hub Regulation Cen-ter MHRC, College of Medicine, Dong-A University, Busan, South Korea%Department of Physiology, Mitochondria Hub Regulation Center MHRC, College of Medicine, Dong-A University, Busan, South Korea</general><general>Medknow Publications & Media Pvt Ltd</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W91</scope><scope>~WA</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88G</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9.</scope><scope>M0S</scope><scope>M2M</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>2B.</scope><scope>4A8</scope><scope>92I</scope><scope>93N</scope><scope>PSX</scope><scope>TCJ</scope><scope>5PM</scope></search><sort><creationdate>20141115</creationdate><title>Two faces of Schwann cell dedifferentiation in peripheral neurodegenerative diseases：pro-demyelinating and axon-preservative functions</title><author>Kim, Jong Kuk ; Lee, Hye Jeong ; Park, Hwan Tae</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c554t-9d7347c9049864b2b4ed48b815a0eb9336e20fd86bedb3d7a67dd3b3d38b9b093</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Cell differentiation</topic><topic>Defense mechanisms</topic><topic>Degeneration</topic><topic>Gene expression</topic><topic>Kinases</topic><topic>Nervous system</topic><topic>Neurodegeneration</topic><topic>Neurophysiology</topic><topic>Peripheral neuropathy</topic><topic>Physiological aspects</topic><topic>Proteins</topic><topic>Schwann cells</topic><topic>Transcription factors</topic><topic>神经损伤</topic><topic>神经胶质细胞</topic><topic>神经退行性疾病</topic><topic>细胞分化</topic><topic>轴突</topic><topic>防腐功能</topic><topic>雪旺氏细胞</topic><topic>髓鞘</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Jong Kuk</creatorcontrib><creatorcontrib>Lee, Hye Jeong</creatorcontrib><creatorcontrib>Park, Hwan Tae</creatorcontrib><collection>中文科技期刊数据库</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>中文科技期刊数据库-7.0平台</collection><collection>中文科技期刊数据库-医药卫生</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Psychology Database (Alumni)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Psychology Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>Wanfang Data Journals - Hong Kong</collection><collection>WANFANG Data Centre</collection><collection>Wanfang Data Journals</collection><collection>万方数据期刊 - 香港版</collection><collection>China Online Journals (COJ)</collection><collection>China Online Journals (COJ)</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Neural regeneration research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Jong Kuk</au><au>Lee, Hye Jeong</au><au>Park, Hwan Tae</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Two faces of Schwann cell dedifferentiation in peripheral neurodegenerative diseases：pro-demyelinating and axon-preservative functions</atitle><jtitle>Neural regeneration research</jtitle><addtitle>Neural Regeneration Research</addtitle><date>2014-11-15</date><risdate>2014</risdate><volume>9</volume><issue>22</issue><spage>1952</spage><epage>1954</epage><pages>1952-1954</pages><issn>1673-5374</issn><eissn>1876-7958</eissn><abstract>Schwann cells are glial cells that are responsible for the synthesis and maintenance of the myelin sheath in the peripheral nerve system. Under pathological conditions, such as physical nerve injury and inflammatory neuropathies, Schwann cells undergo a substantial phenotype transformation that is not related to their intended function. For example, Schwann cells dedifferentiate into immature states and thereby cease to express myelin genes after nerve injury.</abstract><cop>India</cop><pub>Medknow Publications and Media Pvt. Ltd</pub><pmid>25598775</pmid><doi>10.4103/1673-5374.145370</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Neural regeneration research, 2014-11, Vol.9 (22), p.1952-1954 |
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| source | Medknow Open Access Medical Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central Open Access; Journals@Ovid Ovid Autoload; PubMed Central; Alma/SFX Local Collection |
| subjects | Cell differentiation Defense mechanisms Degeneration Gene expression Kinases Nervous system Neurodegeneration Neurophysiology Peripheral neuropathy Physiological aspects Proteins Schwann cells Transcription factors 神经损伤 神经胶质细胞 神经退行性疾病 细胞分化 轴突 防腐功能 雪旺氏细胞 髓鞘 |
| title | Two faces of Schwann cell dedifferentiation in peripheral neurodegenerative diseases：pro-demyelinating and axon-preservative functions |
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