Host Immune System Gene Targeting by a Viral miRNA

Virally encoded microRNAs (miRNAs) have recently been discovered in herpesviruses. However, their biological roles are mostly unknown. We developed an algorithm for the prediction of miRNA targets and applied it to human cytomegalovirus miRNAs, resulting in the identification of the major histocompa...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Science (American Association for the Advancement of Science) 2007-07, Vol.317 (5836), p.376-381
Hauptverfasser:	Stern-Ginossar, Noam, Elefant, Naama, Zimmermann, Albert, Wolf, Dana G, Saleh, Nivin, Biton, Moshe, Horwitz, Elad, Prokocimer, Zafnat, Prichard, Mark, Hahn, Gabriele, Goldman-Wohl, Debra, Greenfield, Caryn, Yagel, Simcha, Hengel, Hartmut, Altuvia, Yael, Margalit, Hanah, Mandelboim, Ofer
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated Regions - metabolism Algorithms Binding Sites Biological and medical sciences Cell Line, Tumor Cells, Cultured Cytomegalovirus - genetics Cytomegalovirus - immunology Cytomegalovirus - pathogenicity Cytotoxicity, Immunologic Down regulation Fundamental and applied biological sciences. Psychology Genetics HeLa cells Histocompatibility Antigens Class I - genetics Histocompatibility Antigens Class I - metabolism Histograms Human cytomegalovirus Humans Immune system Immunology Infections Killer Cells, Natural - immunology Ligands Mica Microbiology MicroRNA MicroRNAs - genetics MicroRNAs - metabolism Natural killer cells NK Cell Lectin-Like Receptor Subfamily K Receptors, Immunologic - metabolism Receptors, Natural Killer Cell Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains Ribonucleic acid RNA RNA, Viral - metabolism Three prime untranslated regions Transduction, Genetic Virology Viruses
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!