Public health genomics and personalized prevention: lessons from the COGS project
Using the principles of public health genomics, we examined the opportunities and challenges of implementing personalized prevention programmes for cancer at the population level. Our model‐based estimates indicate that polygenic risk stratification can potentially improve the effectiveness and cost...
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| Veröffentlicht in: | Journal of internal medicine 2013-11, Vol.274 (5), p.451-456 |
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| container_end_page | 456 |
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| container_issue | 5 |
| container_start_page | 451 |
| container_title | Journal of internal medicine |
| container_volume | 274 |
| creator | Pashayan, N. Hall, A. Chowdhury, S. Dent, T. Pharoah, P. D. P. Burton, H. |
| description | Using the principles of public health genomics, we examined the opportunities and challenges of implementing personalized prevention programmes for cancer at the population level. Our model‐based estimates indicate that polygenic risk stratification can potentially improve the effectiveness and cost‐effectiveness of screening programmes. However, compared with ‘one‐size‐fits‐all’ screening programmes, personalized screening adds further layers of complexity to the organization of screening services and raises ethical, legal and social challenges. Before polygenic inheritance is translated into population screening strategy, evidence from empirical research and engagement with and education of the public and the health professionals are needed. |
| doi_str_mv | 10.1111/joim.12094 |
| format | Article |
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| ispartof | Journal of internal medicine, 2013-11, Vol.274 (5), p.451-456 |
| issn | 0954-6820 1365-2796 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Wiley Free Content; IngentaConnect Free/Open Access Journals |
| subjects | ethical Genetic Predisposition to Disease - genetics Genetic Testing - methods Genomics - methods Humans legal and social issues Neoplasms - diagnosis Neoplasms - genetics Neoplasms - prevention & control personalized prevention polygenic risk stratification Precision Medicine - methods public health genomics Risk Assessment screening Symposium: Cogs Symposium |
| title | Public health genomics and personalized prevention: lessons from the COGS project |
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