Hematopoietic stem cell transplantation rescues the immunologic phenotype and prevents vasculopathy in patients with adenosine deaminase 2 deficiency

Despite the addition of mycophenolate mofetil, sirolimus, tacrolimus, cyclosporine, and mercaptopurine, the cytopenia and lymphoproliferation persisted. Because of growth failure secondary to chronic corticosteroid treatment, HSCT was considered at the age of 3 years. Immunoreconstitution at day 360...

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Veröffentlicht in:	Journal of allergy and clinical immunology 2015-01, Vol.135 (1), p.283-287.e5
Hauptverfasser:	Van Eyck, Lien, MD, Hershfield, Michael S., MD, Pombal, Diana, MSc, Kelly, Susan J., PhD, Ganson, Nancy J., PhD, Moens, Leen, PhD, Frans, Glynis, MPharm, Schaballie, Heidi, MD, De Hertogh, Gert, MD, PhD, Dooley, James, MSc, Bossuyt, Xavier, MD, PhD, Wouters, Carine, MD, PhD, Liston, Adrian, PhD, Meyts, Isabelle, MD, PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Deaminase - blood Adenosine Deaminase - deficiency Adenosine Deaminase - genetics Adenosine Deaminase - immunology Agammaglobulinemia - blood Agammaglobulinemia - genetics Agammaglobulinemia - immunology Agammaglobulinemia - therapy Allergy and Immunology Bone marrow Child, Preschool Hematopoietic Stem Cell Transplantation Humans Immune system Infant Intercellular Signaling Peptides and Proteins - blood Intercellular Signaling Peptides and Proteins - deficiency Intercellular Signaling Peptides and Proteins - genetics Interleukin-6 - blood Letter to the Editor Lymphocyte Count Lymphocytes Male Medical treatment Mutation Phenotype Severe Combined Immunodeficiency - blood Severe Combined Immunodeficiency - genetics Severe Combined Immunodeficiency - immunology Severe Combined Immunodeficiency - therapy Stem cells
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