Arginine deprivation affects glioblastoma cell adhesion, invasiveness and actin cytoskeleton organization by impairment of β-actin arginylation

A deficit of exogenous arginine affects growth and viability of numerous cancer cells. Although arginine deprivation-based strategy is currently undergoing clinical trials, molecular mechanisms of tumor cells’ response to arginine deprivation are not yet elucidated. We have examined effects of argin...

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Veröffentlicht in:	Amino acids 2015-01, Vol.47 (1), p.199-212
Hauptverfasser:	Pavlyk, Iuliia, Rzhepetskyy, Yuriy, Jagielski, Adam K, Drozak, Jakub, Wasik, Anna, Pereverzieva, Galyna, Olchowik, Marta, Kunz-Schugart, Leoni A, Stasyk, Oleh, Redowicz, Maria Jolanta
Format:	Artikel
Sprache:	eng
Schlagworte:	actin Actin Cytoskeleton - metabolism Actins - metabolism Adhesion Amino acids Analytical Chemistry arginine Arginine - metabolism Biochemical Engineering Biochemistry Biomedical and Life Sciences brain Brain Neoplasms - metabolism Brain Neoplasms - pathology Brain Neoplasms - physiopathology Cell Adhesion cell invasion Cell Line, Tumor cell movement clinical trials Cytoskeleton - metabolism Deprivation Filaments Glioblastoma - metabolism Glioblastoma - pathology Glioblastoma - physiopathology Humans Life Sciences lysine microfilaments neoplasm cells Neoplasm Invasiveness neoplasms Neurobiology Organizations Original Original Article Patients Proteomics starvation Strategy therapeutics Tumors viability
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