Solution NMR characterization of WT CXCL8 monomer and dimer binding to CXCR1 N‐terminal domain

Chemokine CXCL8 and its receptor CXCR1 are key mediators in combating infection and have also been implicated in the pathophysiology of various diseases including chronic obstructive pulmonary disease (COPD) and cancer. CXCL8 exists as monomers and dimers but monomer alone binds CXCR1 with high affi...

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Veröffentlicht in:	Protein science 2015-01, Vol.24 (1), p.81-92
Hauptverfasser:	Joseph, Prem Raj B., Rajarathnam, Krishna
Format:	Artikel
Sprache:	eng
Schlagworte:	affinity Amino Acid Sequence Binding Sites Chronic obstructive pulmonary disease CXCL8 Full-Length Papers human CXCR1 N‐domain Humans Interleukin-8 - chemistry Interleukin-8 - metabolism Models, Molecular Molecular Sequence Data monomer‐dimer equilibrium Nuclear Magnetic Resonance, Biomolecular Protein Binding Protein Multimerization Protein Structure, Tertiary Receptors, Interleukin-8A - chemistry Receptors, Interleukin-8A - metabolism solution NMR
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