Ligation of TLR7 by rheumatoid arthritis synovial fluid single strand RNA induces transcription of TNFα in monocytes

Objective The aim of the study was to characterise the expression, regulation and pathogenic role of toll-like receptor 7 (TLR7) and TLR8 in rheumatoid arthritis (RA). Methods Expression of TLR7 and TLR8 was demonstrated in RA, osteoarthritis (OA) and normal (NL) synovial tissues (STs) employing imm...

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Veröffentlicht in:	Annals of the rheumatic diseases 2013-03, Vol.72 (3), p.418-426
Hauptverfasser:	Chamberlain, Nathan D, Kim, Seung-jae, Vila, Olga M, Volin, Michael V, Volkov, Suncica, Pope, Richard M, Arami, Shiva, Mandelin, Arthur M, Shahrara, Shiva
Format:	Artikel
Sprache:	eng
Schlagworte:	Arthritis, Rheumatoid - metabolism Blotting, Western Enzyme-Linked Immunosorbent Assay Female Humans Immunohistochemistry Male Middle Aged Monocytes - metabolism Real-Time Polymerase Chain Reaction Reverse Transcriptase Polymerase Chain Reaction RNA - metabolism Synovial Fluid - metabolism Toll-Like Receptor 7 - biosynthesis Toll-Like Receptor 8 - biosynthesis Transcription, Genetic Tumor Necrosis Factor-alpha - biosynthesis
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