Mito-protective autophagy is impaired in erythroid cells of aged mtDNA-mutator mice

Somatic mitochondrial DNA (mtDNA) mutations contribute to the pathogenesis of age-related disorders, including myelodysplastic syndromes (MDS). The accumulation of mitochondria harboring mtDNA mutations in patients with these disorders suggests a failure of normal mitochondrial quality-control syste...

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Veröffentlicht in:	Blood 2015-01, Vol.125 (1), p.162-174
Hauptverfasser:	Li-Harms, XiuJie, Milasta, Sandra, Lynch, John, Wright, Christopher, Joshi, Aashish, Iyengar, Rekha, Neale, Geoffrey, Wang, Xi, Wang, Yong-Dong, Prolla, Tomas A., Thompson, James E., Opferman, Joseph T., Green, Douglas R., Schuetz, John, Kundu, Mondira
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Anemia - genetics Animals Autophagy - genetics Cell Separation DNA Polymerase gamma DNA, Mitochondrial - genetics DNA-Directed DNA Polymerase - metabolism Erythrocytes - cytology Erythroid Cells - metabolism Flow Cytometry Heterozygote Mice Mitochondria - metabolism Mutation Myelodysplastic Syndromes - genetics Oxygen Consumption Phenotype Phosphorylation Proteasome Endopeptidase Complex - metabolism Red Cells, Iron, and Erythropoiesis Ribosomes - metabolism TOR Serine-Threonine Kinases - metabolism
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