Antibiotic resistance and extended spectrum beta-lactamases: Types, epidemiology and treatment
Antibiotic resistance is a problem of deep scientific concern both in hospital and community settings. Rapid detection in clinical laboratories is essential for the judicious recognition of antimicrobial resistant organisms. Production of extended-spectrum β-lactamases (ESBLs) is a significant resis...
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| Veröffentlicht in: | Saudi journal of biological sciences 2015-01, Vol.22 (1), p.90-101 |
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| creator | Shaikh, Sibhghatulla Fatima, Jamale Shakil, Shazi Rizvi, Syed Mohd. Danish Kamal, Mohammad Amjad |
| description | Antibiotic resistance is a problem of deep scientific concern both in hospital and community settings. Rapid detection in clinical laboratories is essential for the judicious recognition of antimicrobial resistant organisms. Production of extended-spectrum β-lactamases (ESBLs) is a significant resistance-mechanism that impedes the antimicrobial treatment of infections caused by Enterobacteriaceae and is a serious threat to the currently available antibiotic armory. ESBLs are classified into several groups according to their amino acid sequence homology. Proper infection control practices and barriers are essential to prevent spread and outbreaks of ESBL producing bacteria. As bacteria have developed different strategies to counter the effects of antibiotics, the identification of the resistance mechanism may help in the discovery and design of new antimicrobial agents. The carbapenems are widely regarded as the drugs of choice for the treatment of severe infections caused by ESBL-producing Enterobacteriaceae, although comparative clinical trials are scarce. Hence, more expeditious diagnostic testing of ESBL-producing bacteria and the feasible modification of guidelines for community-onset bacteremia associated with different infections are prescribed. |
| doi_str_mv | 10.1016/j.sjbs.2014.08.002 |
| format | Article |
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As bacteria have developed different strategies to counter the effects of antibiotics, the identification of the resistance mechanism may help in the discovery and design of new antimicrobial agents. The carbapenems are widely regarded as the drugs of choice for the treatment of severe infections caused by ESBL-producing Enterobacteriaceae, although comparative clinical trials are scarce. 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All rights reserved. 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c720t-a6b1296427cd993ffb118f17c8b15ed2679c7aa9613d0f71013de5a56f646ccd3</citedby><cites>FETCH-LOGICAL-c720t-a6b1296427cd993ffb118f17c8b15ed2679c7aa9613d0f71013de5a56f646ccd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4281622/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1319562X14000941$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,3537,27901,27902,53766,53768,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25561890$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shaikh, Sibhghatulla</creatorcontrib><creatorcontrib>Fatima, Jamale</creatorcontrib><creatorcontrib>Shakil, Shazi</creatorcontrib><creatorcontrib>Rizvi, Syed Mohd. Danish</creatorcontrib><creatorcontrib>Kamal, Mohammad Amjad</creatorcontrib><title>Antibiotic resistance and extended spectrum beta-lactamases: Types, epidemiology and treatment</title><title>Saudi journal of biological sciences</title><addtitle>Saudi J Biol Sci</addtitle><description>Antibiotic resistance is a problem of deep scientific concern both in hospital and community settings. Rapid detection in clinical laboratories is essential for the judicious recognition of antimicrobial resistant organisms. Production of extended-spectrum β-lactamases (ESBLs) is a significant resistance-mechanism that impedes the antimicrobial treatment of infections caused by Enterobacteriaceae and is a serious threat to the currently available antibiotic armory. ESBLs are classified into several groups according to their amino acid sequence homology. Proper infection control practices and barriers are essential to prevent spread and outbreaks of ESBL producing bacteria. As bacteria have developed different strategies to counter the effects of antibiotics, the identification of the resistance mechanism may help in the discovery and design of new antimicrobial agents. The carbapenems are widely regarded as the drugs of choice for the treatment of severe infections caused by ESBL-producing Enterobacteriaceae, although comparative clinical trials are scarce. Hence, more expeditious diagnostic testing of ESBL-producing bacteria and the feasible modification of guidelines for community-onset bacteremia associated with different infections are prescribed.</description><subject>Amino acid</subject><subject>amino acid sequences</subject><subject>Amino acids</subject><subject>antibiotic resistance</subject><subject>Antibiotics</subject><subject>Antimicrobial agents</subject><subject>bacteremia</subject><subject>bacteria</subject><subject>Beta lactamases</subject><subject>beta-lactamase</subject><subject>Carbapenems</subject><subject>clinical trials</subject><subject>control methods</subject><subject>disease control</subject><subject>Drug resistance in microorganisms</subject><subject>drugs</subject><subject>Enterobacteriaceae</subject><subject>epidemiology</subject><subject>Extended-spectrum β-lactamase</subject><subject>guidelines</subject><subject>hospitals</subject><subject>Original</subject><subject>rapid methods</subject><subject>sequence homology</subject><subject>الأحماض الأمينية</subject><subject>الأحماض العضوية</subject><subject>الأدوية</subject><subject>المركبات الأمينية</subject><issn>1319-562X</issn><issn>2213-7106</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><recordid>eNqFkU2LFDEQhoMo7rj6BwSljx7stirpTnfLIiyLX7DgZQVPhnRSvWboL5PM4vx708446EVPBan3fStVD2NPEQoElK-2Rdh2oeCAZQFNAcDvsQ3nKPIaQd5nGxTY5pXkX87YoxC2ALIRDT5kZ7yqJDYtbNjXyym6zs3RmcxTcCHqyVCmJ5vRj0iTJZuFhUz0uzHrKOp80CbqUQcKr7Ob_ULhZUaLszS6eZhv97-s0ZOOI03xMXvQ6yHQk2M9Z5_fvb25-pBff3r_8eryOjc1h5hr2SFvZclrY9tW9H2H2PRYm6bDiiyXdWtqrVuJwkKftkuVKl3JXpbSGCvO2ZtD7rLrRrImjfZ6UIt3o_Z7NWun_u5M7pu6ne9UyRuUnKeAF8cAP3_fUYhqdMHQMOiJ5l1QHABKKVoO_5WiLAWW6cBrKj9IjZ9D8NSffoSgVoZqq1aGamWooFGJYTI9_3OXk-U3tCR4dhBQeqdenxSlqEW99i-O_XTxO0deBeMoYbXOJ5LKzu5f838ChLW5ZA</recordid><startdate>20150101</startdate><enddate>20150101</enddate><creator>Shaikh, Sibhghatulla</creator><creator>Fatima, Jamale</creator><creator>Shakil, Shazi</creator><creator>Rizvi, Syed Mohd. 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| source | Elsevier ScienceDirect Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Amino acid amino acid sequences Amino acids antibiotic resistance Antibiotics Antimicrobial agents bacteremia bacteria Beta lactamases beta-lactamase Carbapenems clinical trials control methods disease control Drug resistance in microorganisms drugs Enterobacteriaceae epidemiology Extended-spectrum β-lactamase guidelines hospitals Original rapid methods sequence homology الأحماض الأمينية الأحماض العضوية الأدوية المركبات الأمينية |
| title | Antibiotic resistance and extended spectrum beta-lactamases: Types, epidemiology and treatment |
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