Mirror-Image Organometallic Osmium Arene Iminopyridine Halido Complexes Exhibit Similar Potent Anticancer Activity

Four chiral OsII arene anticancer complexes have been isolated by fractional crystallization. The two iodido complexes, (SOs,SC)‐[Os(η6‐p‐cym)(ImpyMe)I]PF6 (complex 2, (S)‐ImpyMe: N‐(2‐pyridylmethylene)‐(S)‐1‐phenylethylamine) and (ROs,RC)‐[Os(η6‐p‐cym)(ImpyMe)I]PF6 (complex 4, (R)‐ImpyMe: N‐(2‐pyri...

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Veröffentlicht in:	Chemistry : a European journal 2013-11, Vol.19 (45), p.15199-15209
Hauptverfasser:	Fu, Ying, Soni, Rina, Romero, María J., Pizarro, Ana M., Salassa, Luca, Clarkson, Guy J., Hearn, Jessica M., Habtemariam, Abraha, Wills, Martin, Sadler, Peter J.
Format:	Artikel
Sprache:	eng
Schlagworte:	anticancer agents Anticancer properties Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use arene ligands Aromatic compounds Cancer Catalysis Catalysts Cell Line, Tumor Chemistry chirality Fractional crystallization Humans Imines Ligands Medical research organometallic Organometallic Compounds - chemistry osmium Osmium - chemistry Osmium - therapeutic use Ovarian cancer Reduction X-Ray Diffraction
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