Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens

A carcinogen-induced mouse tumour model is used here to show that mutant tumour-specific antigens are targets for CD8 + T-cell responses, mediating tumour regression after checkpoint blockade immunotherapy, and that these antigens can be used effectively in therapeutic vaccines; this advance potenti...

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Veröffentlicht in:	Nature (London) 2014-11, Vol.515 (7528), p.577-581
Hauptverfasser:	Gubin, Matthew M., Zhang, Xiuli, Schuster, Heiko, Caron, Etienne, Ward, Jeffrey P., Noguchi, Takuro, Ivanova, Yulia, Hundal, Jasreet, Arthur, Cora D., Krebber, Willem-Jan, Mulder, Gwenn E., Toebes, Mireille, Vesely, Matthew D., Lam, Samuel S. K., Korman, Alan J., Allison, James P., Freeman, Gordon J., Sharpe, Arlene H., Pearce, Erika L., Schumacher, Ton N., Aebersold, Ruedi, Rammensee, Hans-Georg, Melief, Cornelis J. M., Mardis, Elaine R., Gillanders, William E., Artyomov, Maxim N., Schreiber, Robert D.
Format:	Artikel
Sprache:	eng
Schlagworte:	45 45/23 45/91 631/250/251/1574 64/60 82/47 82/58 82/75 Analysis Animals Antibodies, Monoclonal - therapeutic use Antigenic determinants Antigens Antigens, Neoplasm - genetics Antigens, Neoplasm - immunology Bioinformatics Cancer Cancer Vaccines - therapeutic use Care and treatment CD8-Positive T-Lymphocytes - immunology Cell Cycle Checkpoints - immunology Development and progression Drug therapy Epitopes - genetics Health aspects Humanities and Social Sciences Immune system Immunogenicity Immunotherapy letter Lymphocytes Male Mice multidisciplinary Mutants Mutation Peptides Sarcoma Sarcoma - immunology Sarcoma - therapy Science Tumors Vaccines Vaccines, Synthetic - therapeutic use
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