Regulation of human 3β-hydroxysteroid dehydrogenase type 2 by adrenal corticosteroids and product-feedback by androstenedione in human adrenarche

In human adrenarche during childhood, the secretion of dehydroepiandrosterone (DHEA) from the adrenal gland increases due to its increased synthesis and/or decreased metabolism. DHEA is synthesized by 17α-hydroxylase/17,20-lyase, and is metabolized by 3β-hydroxysteroid dehydrogenase type 2 (3βHSD2)....

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Veröffentlicht in:	The Journal of pharmacology and experimental therapeutics 2015-01, Vol.352 (1), p.67-76
Hauptverfasser:	Thomas, James L, Rajapaksha, Maheshinie, Mack, Vance L, DeMars, Geneva A, Majzoub, Joseph A, Bose, Himangshu S
Format:	Artikel
Sprache:	eng
Schlagworte:	17-Hydroxysteroid Dehydrogenases - antagonists & inhibitors 17-Hydroxysteroid Dehydrogenases - chemistry 17-Hydroxysteroid Dehydrogenases - metabolism Adrenal Glands - drug effects Adrenal Glands - metabolism Adrenarche - drug effects Adrenarche - metabolism Adrenarche - physiology Androstenedione - metabolism Androstenedione - pharmacology Cell Line Cortisone - metabolism Cortisone - pharmacology Endocrine and Diabetes Enzyme Inhibitors - metabolism Enzyme Inhibitors - pharmacology Feedback, Physiological - drug effects Humans Hydrocortisone - metabolism Hydrocortisone - pharmacology Liposomes - metabolism Mitochondria - drug effects Mitochondria - metabolism Protein Conformation Protein Transport - drug effects Solubility
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