DNA Modification Study of Major Depressive Disorder: Beyond Locus-by-Locus Comparisons

Abstract Background Major depressive disorder (MDD) exhibits numerous clinical and molecular features that are consistent with putative epigenetic misregulation. Despite growing interest in epigenetic studies of psychiatric diseases, the methodologies guiding such studies have not been well defined....

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Veröffentlicht in:	Biological psychiatry (1969) 2015-02, Vol.77 (3), p.246-255
Hauptverfasser:	Oh, Gabriel, Wang, Sun-Chong, Pal, Mrinal, Chen, Zheng Fei, Khare, Tarang, Tochigi, Mamoru, Ng, Catherine, Yang, Yeqing A, Kwan, Andrew, Kaminsky, Zachary A, Mill, Jonathan, Gunasinghe, Cerisse, Tackett, Jennifer L, Gottesman, Irving I, Willemsen, Gonneke, de Geus, Eco J.C, Vink, Jacqueline M, Slagboom, P. Eline, Wray, Naomi R, Heath, Andrew C, Montgomery, Grant W, Turecki, Gustavo, Martin, Nicholas G, Boomsma, Dorret I, McGuffin, Peter, Kustra, Rafal, Petronis, Art
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged CpG Islands Depressive Disorder, Major - genetics DNA modification Epigenesis, Genetic Epigenetic outliers Epigenetics Female Heteroscedasticity Humans Leukocytes Major depressive disorder Male Microarray Analysis Middle Aged Molecular networks Prefrontal Cortex Psychiatry Spermatozoa Twins, Monozygotic Young Adult
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