Innate immune function of the adherens junction protein p120-catenin in endothelial response to endotoxin

Sepsis-induced acute lung injury is a common clinical disorder in critically ill patients that is associated with high mortality. In this study, we investigated the role of p120-catenin (p120), a constituent of endothelial adherens junctions, in regulating the innate immune function of lungs. In mic...

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Veröffentlicht in:	The Journal of immunology (1950) 2011-03, Vol.186 (5), p.3180-3187
Hauptverfasser:	Wang, Yan-Lei, Malik, Asrar B, Sun, Yu, Hu, Sanyuan, Reynolds, Albert B, Minshall, Richard D, Hu, Guochang
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Lung Injury - enzymology Acute Lung Injury - immunology Acute Lung Injury - pathology Adherens Junctions - enzymology Adherens Junctions - immunology Adherens Junctions - pathology Animals Catenins - physiology Cells, Cultured Down-Regulation - immunology Endothelium, Vascular - enzymology Endothelium, Vascular - immunology Endothelium, Vascular - pathology Immunity, Innate Inflammation Mediators - physiology Inflammation Mediators - toxicity Lipopolysaccharides - antagonists & inhibitors Lipopolysaccharides - toxicity Male Mice Mice, Inbred C57BL NF-kappa B - physiology p120 GTPase Activating Protein - antagonists & inhibitors p120 GTPase Activating Protein - metabolism p120 GTPase Activating Protein - physiology Rats Shock, Septic - immunology Shock, Septic - metabolism Shock, Septic - pathology Signal Transduction - immunology Toll-Like Receptor 4 - antagonists & inhibitors Toll-Like Receptor 4 - physiology
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