Antioxidant and Antiadipogenic Activities of Galkeun-Tang, a Traditional Korean Herbal Formula
Galkeun-tang (GKT; Galgen-tang in Chinese and Kakkon-to in Japanese), a traditional herbal formula, has been used for treatment of the common cold. Here, we report in vitro antioxidant and antiadipogenic effects of GKT. GKT increased the activities of scavenging 2,2′-azinobis-(3-ethylbenzothiazoline...
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| Veröffentlicht in: | Evidence-based complementary and alternative medicine 2014-01, Vol.2014 (2014), p.1-9 |
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| creator | Seo, Chang-Seob Kim, Ohn-Soon Yoo, Sae-Rom Jeong, Soo-Jin Shin, Hyeun-Kyoo |
| description | Galkeun-tang (GKT; Galgen-tang in Chinese and Kakkon-to in Japanese), a traditional herbal formula, has been used for treatment of the common cold. Here, we report in vitro antioxidant and antiadipogenic effects of GKT. GKT increased the activities of scavenging 2,2′-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) and 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals. GKT also significantly reduced the malondialdehyde (MDA) generation during low-density lipoprotein (LDL) oxidation and the electrophoretic mobility of oxidized LDL, indicating inhibitory effects of GKT on Cu2+-mediated oxidation of LDL. Regarding antiadipogenic activity, GKT treatment significantly suppressed lipid accumulation, triglyceride production, and glycerol-3-phosphate dehydrogenase (GPDH) activity in differentiated 3T3-L1 adipocytes. Consistent with this, GKT significantly reduced the secretion of leptin, a major adipokine, in differentiated 3T3-L1 adipocytes. Overall, our findings suggest that GKT has the potential for antioxidative and antiadipogenic properties. |
| doi_str_mv | 10.1155/2014/763494 |
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Here, we report in vitro antioxidant and antiadipogenic effects of GKT. GKT increased the activities of scavenging 2,2′-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) and 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals. GKT also significantly reduced the malondialdehyde (MDA) generation during low-density lipoprotein (LDL) oxidation and the electrophoretic mobility of oxidized LDL, indicating inhibitory effects of GKT on Cu2+-mediated oxidation of LDL. Regarding antiadipogenic activity, GKT treatment significantly suppressed lipid accumulation, triglyceride production, and glycerol-3-phosphate dehydrogenase (GPDH) activity in differentiated 3T3-L1 adipocytes. Consistent with this, GKT significantly reduced the secretion of leptin, a major adipokine, in differentiated 3T3-L1 adipocytes. Overall, our findings suggest that GKT has the potential for antioxidative and antiadipogenic properties.</description><identifier>ISSN: 1741-427X</identifier><identifier>EISSN: 1741-4288</identifier><identifier>DOI: 10.1155/2014/763494</identifier><identifier>PMID: 25574183</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Adipocytes ; Antioxidants ; Carthamus tinctorius ; Common cold ; Copper ; Dehydrogenases ; Electrophoretic mobility ; Free radicals ; Glycerol ; Glycerol-3-phosphate ; Glycerol-3-phosphate dehydrogenase ; Herbal medicine ; Leptin ; Lipid peroxidation ; Lipids ; Low density lipoprotein ; Malondialdehyde ; Natural products ; Obesity ; Oxidation ; Oxidative stress ; Pathogenesis ; Pueraria lobata ; Secretion ; Sulfonic acid</subject><ispartof>Evidence-based complementary and alternative medicine, 2014-01, Vol.2014 (2014), p.1-9</ispartof><rights>Copyright © 2014 Soo-Jin Jeong et al.</rights><rights>Copyright © 2014 Soo-Jin Jeong et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2014 Soo-Jin Jeong et al. 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c467t-42a31d04439819284273c3b67914fb6902bd013de716d2ec95a354f54b8282773</citedby><cites>FETCH-LOGICAL-c467t-42a31d04439819284273c3b67914fb6902bd013de716d2ec95a354f54b8282773</cites><orcidid>0000-0001-8731-2469 ; 0000-0001-6529-1767</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4276690/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4276690/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25574183$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Bae, Hyunsu</contributor><creatorcontrib>Seo, Chang-Seob</creatorcontrib><creatorcontrib>Kim, Ohn-Soon</creatorcontrib><creatorcontrib>Yoo, Sae-Rom</creatorcontrib><creatorcontrib>Jeong, Soo-Jin</creatorcontrib><creatorcontrib>Shin, Hyeun-Kyoo</creatorcontrib><title>Antioxidant and Antiadipogenic Activities of Galkeun-Tang, a Traditional Korean Herbal Formula</title><title>Evidence-based complementary and alternative medicine</title><addtitle>Evid Based Complement Alternat Med</addtitle><description>Galkeun-tang (GKT; Galgen-tang in Chinese and Kakkon-to in Japanese), a traditional herbal formula, has been used for treatment of the common cold. Here, we report in vitro antioxidant and antiadipogenic effects of GKT. GKT increased the activities of scavenging 2,2′-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) and 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals. GKT also significantly reduced the malondialdehyde (MDA) generation during low-density lipoprotein (LDL) oxidation and the electrophoretic mobility of oxidized LDL, indicating inhibitory effects of GKT on Cu2+-mediated oxidation of LDL. Regarding antiadipogenic activity, GKT treatment significantly suppressed lipid accumulation, triglyceride production, and glycerol-3-phosphate dehydrogenase (GPDH) activity in differentiated 3T3-L1 adipocytes. Consistent with this, GKT significantly reduced the secretion of leptin, a major adipokine, in differentiated 3T3-L1 adipocytes. Overall, our findings suggest that GKT has the potential for antioxidative and antiadipogenic properties.</description><subject>Adipocytes</subject><subject>Antioxidants</subject><subject>Carthamus tinctorius</subject><subject>Common cold</subject><subject>Copper</subject><subject>Dehydrogenases</subject><subject>Electrophoretic mobility</subject><subject>Free radicals</subject><subject>Glycerol</subject><subject>Glycerol-3-phosphate</subject><subject>Glycerol-3-phosphate dehydrogenase</subject><subject>Herbal medicine</subject><subject>Leptin</subject><subject>Lipid peroxidation</subject><subject>Lipids</subject><subject>Low density lipoprotein</subject><subject>Malondialdehyde</subject><subject>Natural products</subject><subject>Obesity</subject><subject>Oxidation</subject><subject>Oxidative stress</subject><subject>Pathogenesis</subject><subject>Pueraria lobata</subject><subject>Secretion</subject><subject>Sulfonic acid</subject><issn>1741-427X</issn><issn>1741-4288</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNkc1vEzEQxS0Eoh9w4o4scUGUUH97fUGKKtqiVuISJE5Ys2tv6rKxU3u3lP--jlKi0hMnz2h-fvM0D6E3lHyiVMpjRqg41ooLI56hfaoFnQnWNM93tf6xhw5KuSaEGa31S7THpKyjhu-jn_M4hnQXHMQRQ3R404ML67T0MXR43o3hNozBF5x6fAbDLz_F2QLi8iMGvMgVrf8jDPgiZQ8Rn_vc1u405dU0wCv0ooeh-NcP7yH6fvplcXI-u_x29vVkfjnrhNJj9QicOiIENw01rKmeecdbpQ0VfasMYa0jlDuvqXLMd0YCl6KXom1Yw7Tmh-jzVnc9tSvvOh_HDINd57CC_McmCPbfSQxXdplubd2kqn4VeP8gkNPN5MtoV6F0fhgg-jQVS5WQWitpWEXfPUGv05TrCYplRDFtjBG0UkdbqsuplOz7nRlK7CY3u8nNbnOr9NvH_nfs36Aq8GELXIXo4Hf4PzVfEd_DI5hLrii_B-7_qFk</recordid><startdate>20140101</startdate><enddate>20140101</enddate><creator>Seo, Chang-Seob</creator><creator>Kim, Ohn-Soon</creator><creator>Yoo, Sae-Rom</creator><creator>Jeong, Soo-Jin</creator><creator>Shin, Hyeun-Kyoo</creator><general>Hindawi Publishing Corporation</general><general>Hindawi Limited</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7T5</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88G</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M2M</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-8731-2469</orcidid><orcidid>https://orcid.org/0000-0001-6529-1767</orcidid></search><sort><creationdate>20140101</creationdate><title>Antioxidant and Antiadipogenic Activities of Galkeun-Tang, a Traditional Korean Herbal Formula</title><author>Seo, Chang-Seob ; 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Galgen-tang in Chinese and Kakkon-to in Japanese), a traditional herbal formula, has been used for treatment of the common cold. Here, we report in vitro antioxidant and antiadipogenic effects of GKT. GKT increased the activities of scavenging 2,2′-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) and 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals. GKT also significantly reduced the malondialdehyde (MDA) generation during low-density lipoprotein (LDL) oxidation and the electrophoretic mobility of oxidized LDL, indicating inhibitory effects of GKT on Cu2+-mediated oxidation of LDL. Regarding antiadipogenic activity, GKT treatment significantly suppressed lipid accumulation, triglyceride production, and glycerol-3-phosphate dehydrogenase (GPDH) activity in differentiated 3T3-L1 adipocytes. Consistent with this, GKT significantly reduced the secretion of leptin, a major adipokine, in differentiated 3T3-L1 adipocytes. Overall, our findings suggest that GKT has the potential for antioxidative and antiadipogenic properties.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>25574183</pmid><doi>10.1155/2014/763494</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-8731-2469</orcidid><orcidid>https://orcid.org/0000-0001-6529-1767</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adipocytes Antioxidants Carthamus tinctorius Common cold Copper Dehydrogenases Electrophoretic mobility Free radicals Glycerol Glycerol-3-phosphate Glycerol-3-phosphate dehydrogenase Herbal medicine Leptin Lipid peroxidation Lipids Low density lipoprotein Malondialdehyde Natural products Obesity Oxidation Oxidative stress Pathogenesis Pueraria lobata Secretion Sulfonic acid |
| title | Antioxidant and Antiadipogenic Activities of Galkeun-Tang, a Traditional Korean Herbal Formula |
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