Synthesis and Evaluation of Novel Analogues of Ripostatins

Ripostatins are polyene macrolactones isolated from the myxobacterium Sorangium cellulosum. They exhibit antibiotic activity by inhibiting bacterial RNA polymerase (RNAP) through a binding site and mechanism that are different from those of current antibacterial drugs. Thus, the ripostatins serve as...

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Veröffentlicht in:	Chemistry : a European journal 2014-09, Vol.20 (38), p.12310-12319
Hauptverfasser:	Tang, Wufeng, Liu, Shuang, Degen, David, Ebright, Richard H., Prusov, Evgeny V.
Format:	Artikel
Sprache:	eng
Schlagworte:	antibacterial agents Antibiotics Antiinfectives and antibacterials Bacteria Binding sites Chemistry Cross coupling Decomposition reactions Derivatives Lactones - chemical synthesis Lactones - chemistry Metathesis Molecular Structure natural products polymerase inhibitors RNA polymerase Stereoisomerism Structure-Activity Relationship structure-activity relationships Synthesis
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