Ecstasy (3,4-methylenedioxymethamphetamine) limits murine gammaherpesvirus-68 induced monokine expression

Abstract While Ecstasy (3,4-methylenedioxymethamphetamine, MDMA) has been shown to modulate immune responses, no studies have addressed drug-induced alterations to viral infection. In this study, bone marrow-derived macrophages were exposed to MDMA, then infected with murine gammaherpesvirus-68, and...

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Veröffentlicht in:	Brain, behavior, and immunity behavior, and immunity, 2008-08, Vol.22 (6), p.912-922
Hauptverfasser:	Nelson, Daniel A, Nirmaier, Jamie L, Singh, Sam J, Tolbert, Melanie D, Bost, Kenneth L
Format:	Artikel
Sprache:	eng
Schlagworte:	3,4-Methylenedioxymethamphetamine Allergy and Immunology Animals Cell Survival - drug effects Cells, Cultured Dose-Response Relationship, Immunologic Ecstasy Enzyme-Linked Immunosorbent Assay Female Gammaherpesvirinae - growth & development Gammaherpesvirus Gene Expression - drug effects Humans Interleukin-6 - biosynthesis Interleukin-6 - genetics Interleukin-6 - secretion Macrophage Macrophages - drug effects Macrophages - metabolism Macrophages - virology Mice Mice, Inbred C57BL Monokines - biosynthesis Monokines - genetics Monokines - secretion N-Methyl-3,4-methylenedioxyamphetamine - chemistry N-Methyl-3,4-methylenedioxyamphetamine - toxicity Psychiatry Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics RNA, Messenger - metabolism
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