Arteries are formed by vein-derived endothelial tip cells
Tissue vascularization entails the formation of a blood vessel plexus, which remodels into arteries and veins. Here we show, by using time-lapse imaging of zebrafish fin regeneration and genetic lineage tracing of endothelial cells in the mouse retina, that vein-derived endothelial tip cells contrib...
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| Veröffentlicht in: | Nature communications 2014-12, Vol.5 (1), p.5758-5758, Article 5758 |
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| creator | Xu, Cong Hasan, Sana S. Schmidt, Inga Rocha, Susana F. Pitulescu, Mara E. Bussmann, Jeroen Meyen, Dana Raz, Erez Adams, Ralf H. Siekmann, Arndt F. |
| description | Tissue vascularization entails the formation of a blood vessel plexus, which remodels into arteries and veins. Here we show, by using time-lapse imaging of zebrafish fin regeneration and genetic lineage tracing of endothelial cells in the mouse retina, that vein-derived endothelial tip cells contribute to emerging arteries. Our movies uncover that arterial-fated tip cells change migration direction and migrate backwards within the expanding vascular plexus. This behaviour critically depends on chemokine receptor
cxcr4a
function. We show that the relevant Cxcr4a ligand Cxcl12a selectively accumulates in newly forming bone tissue even when ubiquitously overexpressed, pointing towards a tissue-intrinsic mode of chemokine gradient formation. Furthermore, we find that
cxcr4a
mutant cells can contribute to developing arteries when in association with wild-type cells, suggesting collective migration of endothelial cells. Together, our findings reveal specific cell migratory behaviours in the developing blood vessel plexus and uncover a conserved mode of artery formation.
Sprouting of new blood vessels depends on the migration of endothelial tip cells into surrounding tissue. Here the authors reveal the existence of a distinct migratory signalling circuit that guides endothelial cells from developing veins to the leading tip position in developing arteries. |
| doi_str_mv | 10.1038/ncomms6758 |
| format | Article |
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cxcr4a
function. We show that the relevant Cxcr4a ligand Cxcl12a selectively accumulates in newly forming bone tissue even when ubiquitously overexpressed, pointing towards a tissue-intrinsic mode of chemokine gradient formation. Furthermore, we find that
cxcr4a
mutant cells can contribute to developing arteries when in association with wild-type cells, suggesting collective migration of endothelial cells. Together, our findings reveal specific cell migratory behaviours in the developing blood vessel plexus and uncover a conserved mode of artery formation.
Sprouting of new blood vessels depends on the migration of endothelial tip cells into surrounding tissue. Here the authors reveal the existence of a distinct migratory signalling circuit that guides endothelial cells from developing veins to the leading tip position in developing arteries.</description><identifier>ISSN: 2041-1723</identifier><identifier>EISSN: 2041-1723</identifier><identifier>DOI: 10.1038/ncomms6758</identifier><identifier>PMID: 25502622</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>14 ; 14/19 ; 14/35 ; 14/63 ; 38/71 ; 631/136/16 ; 631/80/84 ; 64/116 ; Animal Fins - blood supply ; Animal Fins - cytology ; Animal Fins - growth & development ; Animal Fins - metabolism ; Animals ; Animals, Genetically Modified ; Arteries - cytology ; Arteries - growth & development ; Arteries - metabolism ; Cell Lineage - genetics ; Cell Movement ; Chemokine CXCL12 - genetics ; Chemokine CXCL12 - metabolism ; Endothelial Cells - cytology ; Endothelial Cells - metabolism ; Endothelium, Vascular - cytology ; Endothelium, Vascular - growth & development ; Endothelium, Vascular - metabolism ; Gene Expression Regulation, Developmental ; Humanities and Social Sciences ; Mice ; multidisciplinary ; Neovascularization, Physiologic ; Receptors, CXCR4 - genetics ; Receptors, CXCR4 - metabolism ; Retina - cytology ; Retina - growth & development ; Retina - metabolism ; Science ; Science (multidisciplinary) ; Signal Transduction ; Time-Lapse Imaging ; Veins - cytology ; Veins - growth & development ; Veins - metabolism ; Zebrafish - genetics ; Zebrafish - metabolism ; Zebrafish Proteins - genetics ; Zebrafish Proteins - metabolism</subject><ispartof>Nature communications, 2014-12, Vol.5 (1), p.5758-5758, Article 5758</ispartof><rights>The Author(s) 2014</rights><rights>Copyright Nature Publishing Group Dec 2014</rights><rights>Copyright © 2014, Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. 2014 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c508t-ab8518a7f378df459d030793966ddc155dbe101ba132267b0f566b7121e54c243</citedby><cites>FETCH-LOGICAL-c508t-ab8518a7f378df459d030793966ddc155dbe101ba132267b0f566b7121e54c243</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4275597/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4275597/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,41096,42165,51551,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25502622$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Xu, Cong</creatorcontrib><creatorcontrib>Hasan, Sana S.</creatorcontrib><creatorcontrib>Schmidt, Inga</creatorcontrib><creatorcontrib>Rocha, Susana F.</creatorcontrib><creatorcontrib>Pitulescu, Mara E.</creatorcontrib><creatorcontrib>Bussmann, Jeroen</creatorcontrib><creatorcontrib>Meyen, Dana</creatorcontrib><creatorcontrib>Raz, Erez</creatorcontrib><creatorcontrib>Adams, Ralf H.</creatorcontrib><creatorcontrib>Siekmann, Arndt F.</creatorcontrib><title>Arteries are formed by vein-derived endothelial tip cells</title><title>Nature communications</title><addtitle>Nat Commun</addtitle><addtitle>Nat Commun</addtitle><description>Tissue vascularization entails the formation of a blood vessel plexus, which remodels into arteries and veins. Here we show, by using time-lapse imaging of zebrafish fin regeneration and genetic lineage tracing of endothelial cells in the mouse retina, that vein-derived endothelial tip cells contribute to emerging arteries. Our movies uncover that arterial-fated tip cells change migration direction and migrate backwards within the expanding vascular plexus. This behaviour critically depends on chemokine receptor
cxcr4a
function. We show that the relevant Cxcr4a ligand Cxcl12a selectively accumulates in newly forming bone tissue even when ubiquitously overexpressed, pointing towards a tissue-intrinsic mode of chemokine gradient formation. Furthermore, we find that
cxcr4a
mutant cells can contribute to developing arteries when in association with wild-type cells, suggesting collective migration of endothelial cells. Together, our findings reveal specific cell migratory behaviours in the developing blood vessel plexus and uncover a conserved mode of artery formation.
Sprouting of new blood vessels depends on the migration of endothelial tip cells into surrounding tissue. Here the authors reveal the existence of a distinct migratory signalling circuit that guides endothelial cells from developing veins to the leading tip position in developing arteries.</description><subject>14</subject><subject>14/19</subject><subject>14/35</subject><subject>14/63</subject><subject>38/71</subject><subject>631/136/16</subject><subject>631/80/84</subject><subject>64/116</subject><subject>Animal Fins - blood supply</subject><subject>Animal Fins - cytology</subject><subject>Animal Fins - growth & development</subject><subject>Animal Fins - metabolism</subject><subject>Animals</subject><subject>Animals, Genetically Modified</subject><subject>Arteries - cytology</subject><subject>Arteries - growth & development</subject><subject>Arteries - metabolism</subject><subject>Cell Lineage - genetics</subject><subject>Cell Movement</subject><subject>Chemokine CXCL12 - genetics</subject><subject>Chemokine CXCL12 - metabolism</subject><subject>Endothelial Cells - cytology</subject><subject>Endothelial Cells - metabolism</subject><subject>Endothelium, Vascular - cytology</subject><subject>Endothelium, Vascular - growth & development</subject><subject>Endothelium, Vascular - metabolism</subject><subject>Gene Expression Regulation, Developmental</subject><subject>Humanities and Social Sciences</subject><subject>Mice</subject><subject>multidisciplinary</subject><subject>Neovascularization, Physiologic</subject><subject>Receptors, CXCR4 - genetics</subject><subject>Receptors, CXCR4 - metabolism</subject><subject>Retina - cytology</subject><subject>Retina - growth & development</subject><subject>Retina - metabolism</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Signal Transduction</subject><subject>Time-Lapse Imaging</subject><subject>Veins - cytology</subject><subject>Veins - growth & development</subject><subject>Veins - metabolism</subject><subject>Zebrafish - genetics</subject><subject>Zebrafish - metabolism</subject><subject>Zebrafish Proteins - genetics</subject><subject>Zebrafish Proteins - metabolism</subject><issn>2041-1723</issn><issn>2041-1723</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNplkV1LwzAYhYMoTuZu_AFS8EaUar7T3Ahj-AUDb_Q6pG26dbTJTLrB_r0pm3NqbpJwHs57Xg4AFwjeIUiye1u4tg1csOwInGFIUYoEJscH7wEYhbCA8RCJMkpPwQAzBjHH-AzIse-Mr01ItDdJ5XxryiTfJGtT27SMyjr-jS1dNzdNrZukq5dJYZomnIOTSjfBjHb3EHw8Pb5PXtLp2_PrZDxNCwazLtV5xlCmRUVEVlaUyRISKCSRnJdlgRgrc4MgyjUiGHORw4pxnguEkWG0wJQMwcPWd7nKY7jC2M7rRi193Wq_UU7X6rdi67maubWiWDAmRTS43hl497kyoVNtHfoVtDVuFRTiRFIpOO9nXf1BF27lbVyvpziSjHAcqZstVXgXgjfVPgyCqi9F_ZQS4cvD-Hv0u4II3G6BECU7M_5g5n-7L8BElik</recordid><startdate>20141215</startdate><enddate>20141215</enddate><creator>Xu, Cong</creator><creator>Hasan, Sana S.</creator><creator>Schmidt, Inga</creator><creator>Rocha, Susana F.</creator><creator>Pitulescu, Mara E.</creator><creator>Bussmann, Jeroen</creator><creator>Meyen, Dana</creator><creator>Raz, Erez</creator><creator>Adams, Ralf H.</creator><creator>Siekmann, Arndt F.</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><general>Nature Pub. 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blood supply</topic><topic>Animal Fins - cytology</topic><topic>Animal Fins - growth & development</topic><topic>Animal Fins - metabolism</topic><topic>Animals</topic><topic>Animals, Genetically Modified</topic><topic>Arteries - cytology</topic><topic>Arteries - growth & development</topic><topic>Arteries - metabolism</topic><topic>Cell Lineage - genetics</topic><topic>Cell Movement</topic><topic>Chemokine CXCL12 - genetics</topic><topic>Chemokine CXCL12 - metabolism</topic><topic>Endothelial Cells - cytology</topic><topic>Endothelial Cells - metabolism</topic><topic>Endothelium, Vascular - cytology</topic><topic>Endothelium, Vascular - growth & development</topic><topic>Endothelium, Vascular - metabolism</topic><topic>Gene Expression Regulation, Developmental</topic><topic>Humanities and Social Sciences</topic><topic>Mice</topic><topic>multidisciplinary</topic><topic>Neovascularization, Physiologic</topic><topic>Receptors, CXCR4 - genetics</topic><topic>Receptors, CXCR4 - metabolism</topic><topic>Retina - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Nature communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xu, Cong</au><au>Hasan, Sana S.</au><au>Schmidt, Inga</au><au>Rocha, Susana F.</au><au>Pitulescu, Mara E.</au><au>Bussmann, Jeroen</au><au>Meyen, Dana</au><au>Raz, Erez</au><au>Adams, Ralf H.</au><au>Siekmann, Arndt F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Arteries are formed by vein-derived endothelial tip cells</atitle><jtitle>Nature communications</jtitle><stitle>Nat Commun</stitle><addtitle>Nat Commun</addtitle><date>2014-12-15</date><risdate>2014</risdate><volume>5</volume><issue>1</issue><spage>5758</spage><epage>5758</epage><pages>5758-5758</pages><artnum>5758</artnum><issn>2041-1723</issn><eissn>2041-1723</eissn><abstract>Tissue vascularization entails the formation of a blood vessel plexus, which remodels into arteries and veins. Here we show, by using time-lapse imaging of zebrafish fin regeneration and genetic lineage tracing of endothelial cells in the mouse retina, that vein-derived endothelial tip cells contribute to emerging arteries. Our movies uncover that arterial-fated tip cells change migration direction and migrate backwards within the expanding vascular plexus. This behaviour critically depends on chemokine receptor
cxcr4a
function. We show that the relevant Cxcr4a ligand Cxcl12a selectively accumulates in newly forming bone tissue even when ubiquitously overexpressed, pointing towards a tissue-intrinsic mode of chemokine gradient formation. Furthermore, we find that
cxcr4a
mutant cells can contribute to developing arteries when in association with wild-type cells, suggesting collective migration of endothelial cells. Together, our findings reveal specific cell migratory behaviours in the developing blood vessel plexus and uncover a conserved mode of artery formation.
Sprouting of new blood vessels depends on the migration of endothelial tip cells into surrounding tissue. Here the authors reveal the existence of a distinct migratory signalling circuit that guides endothelial cells from developing veins to the leading tip position in developing arteries.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>25502622</pmid><doi>10.1038/ncomms6758</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 14 14/19 14/35 14/63 38/71 631/136/16 631/80/84 64/116 Animal Fins - blood supply Animal Fins - cytology Animal Fins - growth & development Animal Fins - metabolism Animals Animals, Genetically Modified Arteries - cytology Arteries - growth & development Arteries - metabolism Cell Lineage - genetics Cell Movement Chemokine CXCL12 - genetics Chemokine CXCL12 - metabolism Endothelial Cells - cytology Endothelial Cells - metabolism Endothelium, Vascular - cytology Endothelium, Vascular - growth & development Endothelium, Vascular - metabolism Gene Expression Regulation, Developmental Humanities and Social Sciences Mice multidisciplinary Neovascularization, Physiologic Receptors, CXCR4 - genetics Receptors, CXCR4 - metabolism Retina - cytology Retina - growth & development Retina - metabolism Science Science (multidisciplinary) Signal Transduction Time-Lapse Imaging Veins - cytology Veins - growth & development Veins - metabolism Zebrafish - genetics Zebrafish - metabolism Zebrafish Proteins - genetics Zebrafish Proteins - metabolism |
| title | Arteries are formed by vein-derived endothelial tip cells |
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