Control of membrane gaps by synaptotagmin-Ca2+ measured with a novel membrane distance ruler

Fast synchronous neurotransmitter release is triggered by calcium that activates synaptotagmin-1 (syt-1), resulting in fusion of synaptic vesicles with the presynaptic membrane. Syt-1 possesses two Ca 2+ -binding C2 domains that tether membranes via interactions with anionic phospholipids. It is cap...

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Veröffentlicht in:	Nature communications 2014-12, Vol.5 (1), p.5859-5859, Article 5859
Hauptverfasser:	Lin, Chao-Chen, Seikowski, Jan, Pérez-Lara, Angel, Jahn, Reinhard, Höbartner, Claudia, Walla, Peter Jomo
Format:	Artikel
Sprache:	eng
Schlagworte:	140/125 631/57/2270 631/80/313/2378 Animals Calcium - chemistry Carboxylic Acids Cations, Divalent Cholesterol - chemistry Fluorescent Dyes Gene Expression Humanities and Social Sciences Microscopy, Fluorescence multidisciplinary Oligonucleotides - chemical synthesis Oligonucleotides - chemistry Phosphatidylethanolamines - chemistry Phosphatidylserines - chemistry Presynaptic Terminals - chemistry Presynaptic Terminals - metabolism Proteolipids - chemistry Rats Recombinant Proteins - chemistry Recombinant Proteins - metabolism Science Science (multidisciplinary) SNARE Proteins - chemistry SNARE Proteins - metabolism Synaptic Vesicles - chemistry Synaptic Vesicles - metabolism Synaptotagmin I - chemistry Synaptotagmin I - metabolism Unilamellar Liposomes - chemistry
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