Lack of Correlation Between the CCR5-Δ32 Mutation and Acute Myeloid Leukemia in Iranian Patients
Chemokines and their receptors are crucially important in the pathogenesis of acute myeloblastic leukemia (AML). The CC chemokine receptor 5 (CCR5) is a specific chemokine receptor for CC chemokine ligand 3 (CCL3), CCL4 and CCL5 which all play key roles in identifying cancer properties and localizat...
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| Veröffentlicht in: | Indian journal of hematology & blood transfusion 2015-03, Vol.31 (1), p.29-31 |
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| container_title | Indian journal of hematology & blood transfusion |
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| creator | Khorramdelazad, Hossein Mortazavi, Yousef Momeni, Mohammad Arababadi, Mohammad Kazemi Khandany, Behjat Kalantary Moogooei, Mozhgan Hassanshahi, Gholamhossein |
| description | Chemokines and their receptors are crucially important in the pathogenesis of acute myeloblastic leukemia (AML). The CC chemokine receptor 5 (CCR5) is a specific chemokine receptor for CC chemokine ligand 3 (CCL3), CCL4 and CCL5 which all play key roles in identifying cancer properties and localization of leukemia cells. It has been demonstrated that the known mutation in CCR5 gene (CCR5-Δ32) leads to mal-expression of the receptor and affect its function. The aim of this study was to determine the rate of CCR5-Δ32 mutation within Iranian AML patients. In this study, blood samples were obtained from 60 AML patients and 300 healthy controls. The CCR5-Δ32 mutation was evaluated using Gap-PCR technique. Our results showed that CCR5-Δ32 mutation was not found in the patients, while three out of the controls had hetrozygotic form of this mutation. The rest of studied samples had the wild form of the gene. According to these findings, it can probably be concluded that the CCR5-Δ32 is not associated with susceptibility to AML in Iranian patients. |
| doi_str_mv | 10.1007/s12288-014-0408-y |
| format | Article |
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The CC chemokine receptor 5 (CCR5) is a specific chemokine receptor for CC chemokine ligand 3 (CCL3), CCL4 and CCL5 which all play key roles in identifying cancer properties and localization of leukemia cells. It has been demonstrated that the known mutation in CCR5 gene (CCR5-Δ32) leads to mal-expression of the receptor and affect its function. The aim of this study was to determine the rate of CCR5-Δ32 mutation within Iranian AML patients. In this study, blood samples were obtained from 60 AML patients and 300 healthy controls. The CCR5-Δ32 mutation was evaluated using Gap-PCR technique. Our results showed that CCR5-Δ32 mutation was not found in the patients, while three out of the controls had hetrozygotic form of this mutation. The rest of studied samples had the wild form of the gene. According to these findings, it can probably be concluded that the CCR5-Δ32 is not associated with susceptibility to AML in Iranian patients.</description><identifier>ISSN: 0971-4502</identifier><identifier>EISSN: 0974-0449</identifier><identifier>DOI: 10.1007/s12288-014-0408-y</identifier><identifier>PMID: 25548441</identifier><language>eng</language><publisher>India: Springer India</publisher><subject>Blood Transfusion Medicine ; Hematology ; Human Genetics ; Medicine ; Medicine & Public Health ; Oncology ; Short Communication</subject><ispartof>Indian journal of hematology & blood transfusion, 2015-03, Vol.31 (1), p.29-31</ispartof><rights>Indian Society of Haematology & Transfusion Medicine 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c427y-e6e30d79c2e04ae5956a8d0f4e62cddc8791df774fff3ea7d56906f31c3c683</citedby><cites>FETCH-LOGICAL-c427y-e6e30d79c2e04ae5956a8d0f4e62cddc8791df774fff3ea7d56906f31c3c683</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4275532/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4275532/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27923,27924,41487,42556,51318,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25548441$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Khorramdelazad, Hossein</creatorcontrib><creatorcontrib>Mortazavi, Yousef</creatorcontrib><creatorcontrib>Momeni, Mohammad</creatorcontrib><creatorcontrib>Arababadi, Mohammad Kazemi</creatorcontrib><creatorcontrib>Khandany, Behjat Kalantary</creatorcontrib><creatorcontrib>Moogooei, Mozhgan</creatorcontrib><creatorcontrib>Hassanshahi, Gholamhossein</creatorcontrib><title>Lack of Correlation Between the CCR5-Δ32 Mutation and Acute Myeloid Leukemia in Iranian Patients</title><title>Indian journal of hematology & blood transfusion</title><addtitle>Indian J Hematol Blood Transfus</addtitle><addtitle>Indian J Hematol Blood Transfus</addtitle><description>Chemokines and their receptors are crucially important in the pathogenesis of acute myeloblastic leukemia (AML). The CC chemokine receptor 5 (CCR5) is a specific chemokine receptor for CC chemokine ligand 3 (CCL3), CCL4 and CCL5 which all play key roles in identifying cancer properties and localization of leukemia cells. It has been demonstrated that the known mutation in CCR5 gene (CCR5-Δ32) leads to mal-expression of the receptor and affect its function. The aim of this study was to determine the rate of CCR5-Δ32 mutation within Iranian AML patients. In this study, blood samples were obtained from 60 AML patients and 300 healthy controls. The CCR5-Δ32 mutation was evaluated using Gap-PCR technique. Our results showed that CCR5-Δ32 mutation was not found in the patients, while three out of the controls had hetrozygotic form of this mutation. The rest of studied samples had the wild form of the gene. According to these findings, it can probably be concluded that the CCR5-Δ32 is not associated with susceptibility to AML in Iranian patients.</description><subject>Blood Transfusion Medicine</subject><subject>Hematology</subject><subject>Human Genetics</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Oncology</subject><subject>Short Communication</subject><issn>0971-4502</issn><issn>0974-0449</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><recordid>eNp9kUlOHTEURS0ECk2yACaRh0wK3FYziURKaZA-CiKZW479DIb6NthVRLWPrIs1xT8FiEwysq173r1PvggdUnJMCWlOMmWsbStCRUUEaat5C-2Rrtm8RLf9904rIQnbRfs53xBSUy7kG7TLpBStEHQP6ZU2tzg63MeUYNCjjwF_hPEXQMDjNeC-v5TV42_O8Pk0LrIOFp-aaQR8PsMQvcUrmG5h7TX2AZ8lHbwO-KLAEMb8Fu04PWR493QeoO-fP_3ov1arb1_O-tNVZQRr5gpq4MQ2nWFAhAbZyVq3ljgBNTPWmrbpqHVNI5xzHHRjZd2R2nFquKlbfoA-LK530881WFOSkx7UXfJrnWYVtVf_KsFfq6v4oEq4lJwVg6MngxTvJ8ijWvtsYBh0gDhlRWtBGeFCyILSBTUp5pzAvcRQojbFqKUYVYpRm2LUXGbev97vZeK5iQKwBchFCleQ1E2cUig_9h_XPw8bmvM</recordid><startdate>20150301</startdate><enddate>20150301</enddate><creator>Khorramdelazad, Hossein</creator><creator>Mortazavi, Yousef</creator><creator>Momeni, Mohammad</creator><creator>Arababadi, Mohammad Kazemi</creator><creator>Khandany, Behjat Kalantary</creator><creator>Moogooei, Mozhgan</creator><creator>Hassanshahi, Gholamhossein</creator><general>Springer India</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20150301</creationdate><title>Lack of Correlation Between the CCR5-Δ32 Mutation and Acute Myeloid Leukemia in Iranian Patients</title><author>Khorramdelazad, Hossein ; Mortazavi, Yousef ; Momeni, Mohammad ; Arababadi, Mohammad Kazemi ; Khandany, Behjat Kalantary ; Moogooei, Mozhgan ; Hassanshahi, Gholamhossein</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c427y-e6e30d79c2e04ae5956a8d0f4e62cddc8791df774fff3ea7d56906f31c3c683</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Blood Transfusion Medicine</topic><topic>Hematology</topic><topic>Human Genetics</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Oncology</topic><topic>Short Communication</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Khorramdelazad, Hossein</creatorcontrib><creatorcontrib>Mortazavi, Yousef</creatorcontrib><creatorcontrib>Momeni, Mohammad</creatorcontrib><creatorcontrib>Arababadi, Mohammad Kazemi</creatorcontrib><creatorcontrib>Khandany, Behjat Kalantary</creatorcontrib><creatorcontrib>Moogooei, Mozhgan</creatorcontrib><creatorcontrib>Hassanshahi, Gholamhossein</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Indian journal of hematology & blood transfusion</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Khorramdelazad, Hossein</au><au>Mortazavi, Yousef</au><au>Momeni, Mohammad</au><au>Arababadi, Mohammad Kazemi</au><au>Khandany, Behjat Kalantary</au><au>Moogooei, Mozhgan</au><au>Hassanshahi, Gholamhossein</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lack of Correlation Between the CCR5-Δ32 Mutation and Acute Myeloid Leukemia in Iranian Patients</atitle><jtitle>Indian journal of hematology & blood transfusion</jtitle><stitle>Indian J Hematol Blood Transfus</stitle><addtitle>Indian J Hematol Blood Transfus</addtitle><date>2015-03-01</date><risdate>2015</risdate><volume>31</volume><issue>1</issue><spage>29</spage><epage>31</epage><pages>29-31</pages><issn>0971-4502</issn><eissn>0974-0449</eissn><abstract>Chemokines and their receptors are crucially important in the pathogenesis of acute myeloblastic leukemia (AML). The CC chemokine receptor 5 (CCR5) is a specific chemokine receptor for CC chemokine ligand 3 (CCL3), CCL4 and CCL5 which all play key roles in identifying cancer properties and localization of leukemia cells. It has been demonstrated that the known mutation in CCR5 gene (CCR5-Δ32) leads to mal-expression of the receptor and affect its function. The aim of this study was to determine the rate of CCR5-Δ32 mutation within Iranian AML patients. In this study, blood samples were obtained from 60 AML patients and 300 healthy controls. The CCR5-Δ32 mutation was evaluated using Gap-PCR technique. Our results showed that CCR5-Δ32 mutation was not found in the patients, while three out of the controls had hetrozygotic form of this mutation. The rest of studied samples had the wild form of the gene. According to these findings, it can probably be concluded that the CCR5-Δ32 is not associated with susceptibility to AML in Iranian patients.</abstract><cop>India</cop><pub>Springer India</pub><pmid>25548441</pmid><doi>10.1007/s12288-014-0408-y</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; SpringerLink Journals - AutoHoldings |
| subjects | Blood Transfusion Medicine Hematology Human Genetics Medicine Medicine & Public Health Oncology Short Communication |
| title | Lack of Correlation Between the CCR5-Δ32 Mutation and Acute Myeloid Leukemia in Iranian Patients |
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