Methylation-Dependent Acyl Transfer between Polyketide Synthase and Nonribosomal Peptide Synthetase Modules in Fungal Natural Product Biosynthesis

Biochemical studies of purified and dissected fungal polyketide synthase and nonribosomal peptide synthetase (PKS-NRPS) hybrid enzymes involved in biosynthesis of pseurotin and aspyridone indicate that one α-methylation step during polyketide synthesis is a prerequisite and a key checkpoint for chai...

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Veröffentlicht in:	Organic letters 2014-12, Vol.16 (24), p.6390-6393
Hauptverfasser:	Zou, Yi, Xu, Wei, Tsunematsu, Yuta, Tang, Mancheng, Watanabe, Kenji, Tang, Yi
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Biochemical Phenomena Biological Factors - biosynthesis Biological Factors - chemistry biosynthesis chemical reactions chemical structure fungi Fungi - chemistry Fungi - metabolism Letter Methylation Molecular Structure Peptide Synthases - biosynthesis Peptide Synthases - chemistry Peptide Synthases - metabolism polyketide synthases Polyketide Synthases - chemistry Polyketide Synthases - metabolism polyketides Protein Engineering - methods Pyrones - chemistry Pyrrolidinones - metabolism
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