Runx1t1 Regulates the Neuronal Differentiation of Radial Glial Cells From the Rat Hippocampus

Runx1t1 was knocked down in hippocampal radial glial cells (RGCs) with Runx1t1‐RNA interference using lentiviral vectors. Experimental evidence showed that decreased Runx1t1 expression reduced the neuronal differentiation of RGCs and increased Runx1t1 expression caused a greater number of RGCs to di...

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Veröffentlicht in:	Stem cells translational medicine 2015-01, Vol.4 (1), p.110-116
Hauptverfasser:	Linqing, Zou, Guohua, Jin, Haoming, Li, Xuelei, Tao, Jianbing, Qin, Meiling, Tian
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blotting, Western Cell differentiation Cell Differentiation - physiology Deoxyribonucleic acid Design Differentiation DNA Ependymoglial Cells - cytology Experiments Expression vectors Fluorescent Antibody Technique Gene expression Glial cells Growth factors Hippocampus Hippocampus - cytology Laboratory animals Nervous system Neural Stem Cells - cytology Neurogenesis Neurogenesis - physiology Neuroglia - cytology Neuroglia - metabolism Neuronal-glial interactions Neurons Neurons - cytology Proteins Proto-Oncogene Proteins - metabolism Radial glial cells Rats Real-Time Polymerase Chain Reaction RNA-mediated interference RUNX1 Translocation Partner 1 Protein Runx1t1 Stem cells Tissue Engineering and Regenerative Medicine Transcription factors Transcription Factors - metabolism Transfection
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