Thermodynamic characterization of human telomere quadruplex unfolding

ABSTRACT The 3′‐terminal extensions of eukaryotic chromosomes are unique examples of functional single‐stranded DNA. Human telomeres are constructed of the repeated DNA sequence 5′‐d(TTAGGG). Four‐repeats of human telomeric DNA have been characterized by high‐resolution techniques to be capable of f...

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Veröffentlicht in:	Biopolymers 2013-12, Vol.99 (12), p.1006-1018
Hauptverfasser:	Buscaglia, R., Gray, R. D., Chaires, J. B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Circular Dichroism DNA - chemistry DNA, Single-Stranded G-Quadruplexes Humans Nucleic Acid Conformation quadruplex singular value decomposition spectroscopy Telomere Thermodynamics unfolding
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