Chemical Genetics Screening Reveals KIAA1363 as a Cytokine-Lowering Target

Inflammation is a hallmark of many human diseases, including pain, arthritis, atherosclerosis, obesity and diabetes, cancer, and neurodegenerative diseases. Although there are several successfully marketed small molecules anti-inflammatory drugs such as cyclooxygenase inhibitors and glucocorticoids,...

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Veröffentlicht in:	ACS chemical biology 2014-12, Vol.9 (12), p.2905-2913
Hauptverfasser:	Hunerdosse, Devon M, Morris, Patrick J, Miyamoto, David K, Fisher, Karl J, Bateman, Leslie A, Ghazaleh, Jonathan R, Zhong, Sharon, Nomura, Daniel K
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents - chemical synthesis Anti-Inflammatory Agents - chemistry Anti-Inflammatory Agents - pharmacology Carboxylic Ester Hydrolases - antagonists & inhibitors Carboxylic Ester Hydrolases - genetics Carboxylic Ester Hydrolases - metabolism Cell Line Cytokines - antagonists & inhibitors Cytokines - biosynthesis Gene Expression Regulation High-Throughput Screening Assays Humans Inflammation - drug therapy Inflammation - genetics Inflammation - metabolism Inflammation - pathology Lipid Metabolism - drug effects Lipopolysaccharides - pharmacology Macrophage Activation - drug effects Macrophages - cytology Macrophages - drug effects Macrophages - metabolism Mice Mice, Inbred C57BL Primary Cell Culture Signal Transduction Small Molecule Libraries - pharmacology Sterol Esterase - antagonists & inhibitors Sterol Esterase - genetics Sterol Esterase - metabolism Structure-Activity Relationship
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