The Design of Dextran-Based Hypoxia-Inducible Hydrogels via In Situ Oxygen-Consuming Reaction

Hypoxia plays a critical role in the development and wound healing process, as well as a number of pathological conditions. Here, dextran‐based hypoxia‐inducible (Dex‐HI) hydrogels formed with in situ oxygen consumption via a laccase−medicated reaction are reported. Oxygen levels and gradients were...

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Veröffentlicht in:	Macromolecular rapid communications. 2014-11, Vol.35 (22), p.1968-1975
Hauptverfasser:	Park, Kyung Min, Blatchley, Michael R., Gerecht, Sharon
Format:	Artikel
Sprache:	eng
Schlagworte:	Applied sciences Biocompatible Materials - chemistry Biocompatible Materials - metabolism Biomaterials Biomedical materials Computer simulation dextran Dextrans - chemistry Dextrans - metabolism Exact sciences and technology Hydrogels Hydrogels - chemistry Hydrogels - metabolism Hypoxia Hypoxis - chemistry Hypoxis - metabolism injectable hydrogels Laccase - chemistry Laccase - metabolism laccase-mediated cross-linking reactions Molecular Structure Natural polymers Oxygen Oxygen - chemistry Oxygen - metabolism Oxygen Consumption oxygen controllable hydrogels Physicochemistry of polymers Starch and polysaccharides Surgical implants Wound healing
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