Current Concepts: The Role of Mesenchymal Stem Cells in the Management of Knee Osteoarthritis
Context: The number of adults with osteoarthritis in the United States is expected to nearly double from 21.4 million in 2005 to 41.1 million by 2030. As a result, medical costs and associated comorbidity will exponentially increase in the coming decades. In the past decade, mesenchymal stem cells (...
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| Veröffentlicht in: | Sports health 2015-01, Vol.7 (1), p.38-44 |
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| container_title | Sports health |
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| creator | Wolfstadt, Jesse I. Cole, Brian J. Ogilvie-Harris, Darrell J. Viswanathan, Sowmya Chahal, Jaskarndip |
| description | Context:
The number of adults with osteoarthritis in the United States is expected to nearly double from 21.4 million in 2005 to 41.1 million by 2030. As a result, medical costs and associated comorbidity will exponentially increase in the coming decades. In the past decade, mesenchymal stem cells (MSCs) have emerged as a novel treatment for degenerative joint disease.
Evidence Acquisition:
PubMed (from 1990 to 2013) was searched to identify relevant studies. Reference lists of included studies were also reviewed.
Study Design:
Clinical review.
Level of Evidence:
Level 3.
Results:
We identified 9 animal and 7 human studies investigating the use of MSCs in the treatment of osteoarthritis, with varying levels of support for this therapy.
Conclusion:
While MSCs have shown potential for improving function and decreasing inflammation in animal studies, translation to patients is still in question. There is a great deal of heterogeneity in treatment methods. Standardizing the manufacturing and characterization of MSCs will allow for better comparisons. |
| doi_str_mv | 10.1177/1941738114529727 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4272690</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.1177_1941738114529727</sage_id><sourcerecordid>1641856095</sourcerecordid><originalsourceid>FETCH-LOGICAL-c345t-a889ce7a7b379aab4dd523587a0e59bf14fb865695ceefc7a05280f9cdbafc203</originalsourceid><addsrcrecordid>eNp1UEtLxDAQDqK46yp49CQevVQzaZ4XQYovWPCi55Cmydql26xJK_jvbdl1UcHTDPM95uND6AzwFYAQ16AoiFwCUEaUIGIPTcdThhWB_e0-4hN0lNISY045iEM0IYyxnABM0WnRx-ja7qIIrXXrLh2jA2-a5E62c4Ze7-9eisds_vzwVNzOM5tT1mVGSmWdMKLMhTKmpFXFSM6kMNgxVXqgvpScccWsc94OZ0Yk9spWpfGW4HyGbja-675cucoOGaJp9DrWKxM_dTC1_o209ZtehA9NiSBcjQaXW4MY3nuXOr2qk3VNY1oX-qSBU5CMY8UGKt5QbQwpRed3bwDrsUj9t8hBcv4z3k7w3dxAyDaEZBZOL0Mf26Gu_w2_AOAqelk</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1641856095</pqid></control><display><type>article</type><title>Current Concepts: The Role of Mesenchymal Stem Cells in the Management of Knee Osteoarthritis</title><source>SAGE Complete</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Wolfstadt, Jesse I. ; Cole, Brian J. ; Ogilvie-Harris, Darrell J. ; Viswanathan, Sowmya ; Chahal, Jaskarndip</creator><creatorcontrib>Wolfstadt, Jesse I. ; Cole, Brian J. ; Ogilvie-Harris, Darrell J. ; Viswanathan, Sowmya ; Chahal, Jaskarndip</creatorcontrib><description>Context:
The number of adults with osteoarthritis in the United States is expected to nearly double from 21.4 million in 2005 to 41.1 million by 2030. As a result, medical costs and associated comorbidity will exponentially increase in the coming decades. In the past decade, mesenchymal stem cells (MSCs) have emerged as a novel treatment for degenerative joint disease.
Evidence Acquisition:
PubMed (from 1990 to 2013) was searched to identify relevant studies. Reference lists of included studies were also reviewed.
Study Design:
Clinical review.
Level of Evidence:
Level 3.
Results:
We identified 9 animal and 7 human studies investigating the use of MSCs in the treatment of osteoarthritis, with varying levels of support for this therapy.
Conclusion:
While MSCs have shown potential for improving function and decreasing inflammation in animal studies, translation to patients is still in question. There is a great deal of heterogeneity in treatment methods. Standardizing the manufacturing and characterization of MSCs will allow for better comparisons.</description><identifier>ISSN: 1941-7381</identifier><identifier>EISSN: 1941-0921</identifier><identifier>DOI: 10.1177/1941738114529727</identifier><identifier>PMID: 25553211</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><subject>Focus Topic: Controversies in Sports Medicine</subject><ispartof>Sports health, 2015-01, Vol.7 (1), p.38-44</ispartof><rights>2014 The Author(s)</rights><rights>2014 The Author(s) 2014 American Orthopaedic Society for Sports Medicine</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c345t-a889ce7a7b379aab4dd523587a0e59bf14fb865695ceefc7a05280f9cdbafc203</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4272690/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4272690/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,21799,27903,27904,43600,43601,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25553211$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wolfstadt, Jesse I.</creatorcontrib><creatorcontrib>Cole, Brian J.</creatorcontrib><creatorcontrib>Ogilvie-Harris, Darrell J.</creatorcontrib><creatorcontrib>Viswanathan, Sowmya</creatorcontrib><creatorcontrib>Chahal, Jaskarndip</creatorcontrib><title>Current Concepts: The Role of Mesenchymal Stem Cells in the Management of Knee Osteoarthritis</title><title>Sports health</title><addtitle>Sports Health</addtitle><description>Context:
The number of adults with osteoarthritis in the United States is expected to nearly double from 21.4 million in 2005 to 41.1 million by 2030. As a result, medical costs and associated comorbidity will exponentially increase in the coming decades. In the past decade, mesenchymal stem cells (MSCs) have emerged as a novel treatment for degenerative joint disease.
Evidence Acquisition:
PubMed (from 1990 to 2013) was searched to identify relevant studies. Reference lists of included studies were also reviewed.
Study Design:
Clinical review.
Level of Evidence:
Level 3.
Results:
We identified 9 animal and 7 human studies investigating the use of MSCs in the treatment of osteoarthritis, with varying levels of support for this therapy.
Conclusion:
While MSCs have shown potential for improving function and decreasing inflammation in animal studies, translation to patients is still in question. There is a great deal of heterogeneity in treatment methods. Standardizing the manufacturing and characterization of MSCs will allow for better comparisons.</description><subject>Focus Topic: Controversies in Sports Medicine</subject><issn>1941-7381</issn><issn>1941-0921</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><recordid>eNp1UEtLxDAQDqK46yp49CQevVQzaZ4XQYovWPCi55Cmydql26xJK_jvbdl1UcHTDPM95uND6AzwFYAQ16AoiFwCUEaUIGIPTcdThhWB_e0-4hN0lNISY045iEM0IYyxnABM0WnRx-ja7qIIrXXrLh2jA2-a5E62c4Ze7-9eisds_vzwVNzOM5tT1mVGSmWdMKLMhTKmpFXFSM6kMNgxVXqgvpScccWsc94OZ0Yk9spWpfGW4HyGbja-675cucoOGaJp9DrWKxM_dTC1_o209ZtehA9NiSBcjQaXW4MY3nuXOr2qk3VNY1oX-qSBU5CMY8UGKt5QbQwpRed3bwDrsUj9t8hBcv4z3k7w3dxAyDaEZBZOL0Mf26Gu_w2_AOAqelk</recordid><startdate>20150101</startdate><enddate>20150101</enddate><creator>Wolfstadt, Jesse I.</creator><creator>Cole, Brian J.</creator><creator>Ogilvie-Harris, Darrell J.</creator><creator>Viswanathan, Sowmya</creator><creator>Chahal, Jaskarndip</creator><general>SAGE Publications</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20150101</creationdate><title>Current Concepts</title><author>Wolfstadt, Jesse I. ; Cole, Brian J. ; Ogilvie-Harris, Darrell J. ; Viswanathan, Sowmya ; Chahal, Jaskarndip</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c345t-a889ce7a7b379aab4dd523587a0e59bf14fb865695ceefc7a05280f9cdbafc203</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Focus Topic: Controversies in Sports Medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wolfstadt, Jesse I.</creatorcontrib><creatorcontrib>Cole, Brian J.</creatorcontrib><creatorcontrib>Ogilvie-Harris, Darrell J.</creatorcontrib><creatorcontrib>Viswanathan, Sowmya</creatorcontrib><creatorcontrib>Chahal, Jaskarndip</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Sports health</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wolfstadt, Jesse I.</au><au>Cole, Brian J.</au><au>Ogilvie-Harris, Darrell J.</au><au>Viswanathan, Sowmya</au><au>Chahal, Jaskarndip</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Current Concepts: The Role of Mesenchymal Stem Cells in the Management of Knee Osteoarthritis</atitle><jtitle>Sports health</jtitle><addtitle>Sports Health</addtitle><date>2015-01-01</date><risdate>2015</risdate><volume>7</volume><issue>1</issue><spage>38</spage><epage>44</epage><pages>38-44</pages><issn>1941-7381</issn><eissn>1941-0921</eissn><abstract>Context:
The number of adults with osteoarthritis in the United States is expected to nearly double from 21.4 million in 2005 to 41.1 million by 2030. As a result, medical costs and associated comorbidity will exponentially increase in the coming decades. In the past decade, mesenchymal stem cells (MSCs) have emerged as a novel treatment for degenerative joint disease.
Evidence Acquisition:
PubMed (from 1990 to 2013) was searched to identify relevant studies. Reference lists of included studies were also reviewed.
Study Design:
Clinical review.
Level of Evidence:
Level 3.
Results:
We identified 9 animal and 7 human studies investigating the use of MSCs in the treatment of osteoarthritis, with varying levels of support for this therapy.
Conclusion:
While MSCs have shown potential for improving function and decreasing inflammation in animal studies, translation to patients is still in question. There is a great deal of heterogeneity in treatment methods. Standardizing the manufacturing and characterization of MSCs will allow for better comparisons.</abstract><cop>Los Angeles, CA</cop><pub>SAGE Publications</pub><pmid>25553211</pmid><doi>10.1177/1941738114529727</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Sports health, 2015-01, Vol.7 (1), p.38-44 |
| issn | 1941-7381 1941-0921 |
| language | eng |
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| source | SAGE Complete; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Focus Topic: Controversies in Sports Medicine |
| title | Current Concepts: The Role of Mesenchymal Stem Cells in the Management of Knee Osteoarthritis |
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