Apoptotic Caspases Prevent the Induction of Type I Interferons by Mitochondrial DNA

The mechanism by which cells undergo death determines whether dying cells trigger inflammatory responses or remain immunologically silent. Mitochondria play a central role in the induction of cell death, as well as in immune signaling pathways. Here, we identify a mechanism by which mitochondria and...

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Veröffentlicht in:Cell 2014-12, Vol.159 (7), p.1563-1577
Hauptverfasser: Rongvaux, Anthony, Jackson, Ruaidhrí, Harman, Christian C.D., Li, Tuo, West, A. Phillip, de Zoete, Marcel R., Wu, Youtong, Yordy, Brian, Lakhani, Saquib A., Kuan, Chia-Yi, Taniguchi, Tadatsugu, Shadel, Gerald S., Chen, Zhijian J., Iwasaki, Akiko, Flavell, Richard A.
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Sprache:eng
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