Control of Ras-Mediated Signaling in Aspergillus fumigatus
Pathogenic fungi employ numerous mechanisms to flourish in the stressful environment encountered within their mammalian hosts. Central to this arsenal for filamentous fungi is invasive growth within the host microenvironment, mediated by establishment and maintenance of polarized hyphal morphogenesi...
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| Veröffentlicht in: | Mycopathologia (1975) 2014-12, Vol.178 (5-6), p.325-330 |
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| creator | Norton, Tiffany S. Fortwendel, Jarrod R. |
| description | Pathogenic fungi employ numerous mechanisms to flourish in the stressful environment encountered within their mammalian hosts. Central to this arsenal for filamentous fungi is invasive growth within the host microenvironment, mediated by establishment and maintenance of polarized hyphal morphogenesis. In
Aspergillus fumigatus
, the RasA signal transduction pathway has emerged as a significant regulator of hyphal morphogenesis and virulence, among other processes. The factors contributing to the regulation of RasA itself are not as thoroughly understood, although proper temporal activation of RasA and spatial localization of RasA to the plasma membrane are known to play major roles. Interference with RasA palmitoylation or prenylation results in mislocalization of RasA and is associated with severe growth deficits. In addition, dysregulation of RasA activation results in severe morphologic aberrancies and growth deficits. This review highlights the relationship between RasA signaling, hyphal morphogenesis, and virulence in
A. fumigatus
and focuses on potential determinants of spatial and temporal RasA regulation. |
| doi_str_mv | 10.1007/s11046-014-9765-1 |
| format | Article |
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Aspergillus fumigatus
, the RasA signal transduction pathway has emerged as a significant regulator of hyphal morphogenesis and virulence, among other processes. The factors contributing to the regulation of RasA itself are not as thoroughly understood, although proper temporal activation of RasA and spatial localization of RasA to the plasma membrane are known to play major roles. Interference with RasA palmitoylation or prenylation results in mislocalization of RasA and is associated with severe growth deficits. In addition, dysregulation of RasA activation results in severe morphologic aberrancies and growth deficits. This review highlights the relationship between RasA signaling, hyphal morphogenesis, and virulence in
A. fumigatus
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Aspergillus fumigatus
, the RasA signal transduction pathway has emerged as a significant regulator of hyphal morphogenesis and virulence, among other processes. The factors contributing to the regulation of RasA itself are not as thoroughly understood, although proper temporal activation of RasA and spatial localization of RasA to the plasma membrane are known to play major roles. Interference with RasA palmitoylation or prenylation results in mislocalization of RasA and is associated with severe growth deficits. In addition, dysregulation of RasA activation results in severe morphologic aberrancies and growth deficits. This review highlights the relationship between RasA signaling, hyphal morphogenesis, and virulence in
A. fumigatus
and focuses on potential determinants of spatial and temporal RasA regulation.</description><subject>Aspergillus fumigatus</subject><subject>Aspergillus fumigatus - growth & development</subject><subject>Aspergillus fumigatus - physiology</subject><subject>Biomedical and Life Sciences</subject><subject>Cellular signal transduction</subject><subject>Eukaryotic Microbiology</subject><subject>Fungi</subject><subject>Gene Expression Regulation, Fungal</subject><subject>Genomes</subject><subject>Hyphae - growth & development</subject><subject>Life Sciences</subject><subject>Lipoylation</subject><subject>Localization</subject><subject>Medical Microbiology</subject><subject>Membranes</subject><subject>Microbial Ecology</subject><subject>Microbiology</subject><subject>Morphogenesis</subject><subject>Morphology</subject><subject>Plant Sciences</subject><subject>Plasma</subject><subject>Protein Prenylation</subject><subject>Proteins</subject><subject>ras Proteins - metabolism</subject><subject>Signal Transduction</subject><subject>Virulence</subject><subject>Yeast</subject><issn>0301-486X</issn><issn>1573-0832</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkkFr3DAQhUVpaLZpf0AvxdBLe3CqkWyN1ENgWdImkFJIcuhNKPbYVbCtrWWX5N9HqdOQLRSKDgOa7z1mhsfYG-CHwDl-jAC8UDmHIjeoyhyesRWUKHOupXjOVlxyyAutvu-zlzFec55UgC_YvihMKRBwxT5twjCNoctCk527mH-l2ruJ6uzCt4Pr_NBmfsjWcUtj67tujlkz97510xxfsb3GdZFeP9QDdvn5-HJzkp99-3K6WZ_lFYKY8lqrugCtS4eIDUcAkrqGBoThnBujNJBGLKioNSmJohJojNYOmyvFS3nAjhbb7XzVU11Rmtd1djv63o23NjhvdzuD_2Hb8MsWAoWQmAzePxiM4edMcbK9jxV1nRsozNGCkiUXSkn5H6jAtIEQOqHv_kKvwzymk_2mFIDRpkjU4UK1riPrhyakEav0aup9FQZqfPpfSwMIRnGTBB92BImZ6GZq3RyjPb0432VhYasxxDhS83gU4PY-IHYJiE0BsfcBsZA0b59e81HxJxEJEAsQU2toaXyy1z9d7wDqrsI2</recordid><startdate>20141201</startdate><enddate>20141201</enddate><creator>Norton, Tiffany S.</creator><creator>Fortwendel, Jarrod R.</creator><general>Springer Netherlands</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ISR</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>7TO</scope><scope>H94</scope><scope>5PM</scope></search><sort><creationdate>20141201</creationdate><title>Control of Ras-Mediated Signaling in Aspergillus fumigatus</title><author>Norton, Tiffany S. ; Fortwendel, Jarrod R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c712t-d86d41885a777f0711e38d1f12900099681e8774e4d8e6372c279988a7fb6053</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Aspergillus fumigatus</topic><topic>Aspergillus fumigatus - growth & development</topic><topic>Aspergillus fumigatus - physiology</topic><topic>Biomedical and Life Sciences</topic><topic>Cellular signal transduction</topic><topic>Eukaryotic Microbiology</topic><topic>Fungi</topic><topic>Gene Expression Regulation, Fungal</topic><topic>Genomes</topic><topic>Hyphae - growth & development</topic><topic>Life Sciences</topic><topic>Lipoylation</topic><topic>Localization</topic><topic>Medical Microbiology</topic><topic>Membranes</topic><topic>Microbial Ecology</topic><topic>Microbiology</topic><topic>Morphogenesis</topic><topic>Morphology</topic><topic>Plant Sciences</topic><topic>Plasma</topic><topic>Protein Prenylation</topic><topic>Proteins</topic><topic>ras Proteins - metabolism</topic><topic>Signal Transduction</topic><topic>Virulence</topic><topic>Yeast</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Norton, Tiffany S.</creatorcontrib><creatorcontrib>Fortwendel, Jarrod R.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Mycopathologia (1975)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Norton, Tiffany S.</au><au>Fortwendel, Jarrod R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Control of Ras-Mediated Signaling in Aspergillus fumigatus</atitle><jtitle>Mycopathologia (1975)</jtitle><stitle>Mycopathologia</stitle><addtitle>Mycopathologia</addtitle><date>2014-12-01</date><risdate>2014</risdate><volume>178</volume><issue>5-6</issue><spage>325</spage><epage>330</epage><pages>325-330</pages><issn>0301-486X</issn><eissn>1573-0832</eissn><abstract>Pathogenic fungi employ numerous mechanisms to flourish in the stressful environment encountered within their mammalian hosts. Central to this arsenal for filamentous fungi is invasive growth within the host microenvironment, mediated by establishment and maintenance of polarized hyphal morphogenesis. In
Aspergillus fumigatus
, the RasA signal transduction pathway has emerged as a significant regulator of hyphal morphogenesis and virulence, among other processes. The factors contributing to the regulation of RasA itself are not as thoroughly understood, although proper temporal activation of RasA and spatial localization of RasA to the plasma membrane are known to play major roles. Interference with RasA palmitoylation or prenylation results in mislocalization of RasA and is associated with severe growth deficits. In addition, dysregulation of RasA activation results in severe morphologic aberrancies and growth deficits. This review highlights the relationship between RasA signaling, hyphal morphogenesis, and virulence in
A. fumigatus
and focuses on potential determinants of spatial and temporal RasA regulation.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>24952717</pmid><doi>10.1007/s11046-014-9765-1</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| language | eng |
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| source | MEDLINE; SpringerNature Journals |
| subjects | Aspergillus fumigatus Aspergillus fumigatus - growth & development Aspergillus fumigatus - physiology Biomedical and Life Sciences Cellular signal transduction Eukaryotic Microbiology Fungi Gene Expression Regulation, Fungal Genomes Hyphae - growth & development Life Sciences Lipoylation Localization Medical Microbiology Membranes Microbial Ecology Microbiology Morphogenesis Morphology Plant Sciences Plasma Protein Prenylation Proteins ras Proteins - metabolism Signal Transduction Virulence Yeast |
| title | Control of Ras-Mediated Signaling in Aspergillus fumigatus |
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