Gut‐directed hypnotherapy significantly augments clinical remission in quiescent ulcerative colitis
Summary Background Psychotherapy is not routinely recommended for in ulcerative colitis (UC). Gut‐directed hypnotherapy (HYP) has been linked to improved function in the gastrointestinal tract and may operate through immune‐mediated pathways in chronic diseases. Aims To determine the feasibility and...
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| Veröffentlicht in: | Alimentary pharmacology & therapeutics 2013-10, Vol.38 (7), p.761-771 |
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| container_title | Alimentary pharmacology & therapeutics |
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| creator | Keefer, L. Taft, T. H. Kiebles, J. L. Martinovich, Z. Barrett, T. A. Palsson, O. S. |
| description | Summary
Background
Psychotherapy is not routinely recommended for in ulcerative colitis (UC). Gut‐directed hypnotherapy (HYP) has been linked to improved function in the gastrointestinal tract and may operate through immune‐mediated pathways in chronic diseases.
Aims
To determine the feasibility and acceptability of HYP and estimate the impact of HYP on clinical remission status over a 1‐year period in patients with an historical flare rate of 1.3 times per year.
Methods
A total of 54 patients were randomised at a single site to seven sessions of gut‐directed HYP (n = 26) or attention control (CON; n = 29) and followed for 1 year. The primary outcome was the proportion of participants in each condition that had remained clinically asymptomatic (clinical remission) through 52 weeks post treatment.
Results
One‐way analysis of variance comparing HYP and CON subjects on number of days to clinical relapse favoured the HYP condition [F = 4.8 (1, 48), P = 0.03] by 78 days. Chi‐squared analysis comparing the groups on proportion maintaining remission at 1 year was also significant [χ2(1) = 3.9, P = 0.04], with 68% of HYP and 40% of CON patients maintaining remission for 1 year. There were no significant differences between groups over time in quality of life, medication adherence, perceived stress or psychological factors.
Conclusion
This is the first prospective study that has demonstrated a significant effect of a psychological intervention on prolonging clinical remission in patients with quiescent ulcerative colitis (Clinical Trial # NCT00798642). |
| doi_str_mv | 10.1111/apt.12449 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4271841</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1430398288</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4459-1cb7131777fab883d9697a1db4e6789d5dff269b589561a8d2708eaf21845cd13</originalsourceid><addsrcrecordid>eNp1kctu1DAYhS0EosPAghdA3iDBIq0v8W2DVFWlIFWCRVlbju3MGHmc1E6KsuMReMY-CR5mKLDAG0v253PO7wPAS4xOcV1nZpxOMWlb9QisMOWsIYjyx2CFCFcNkZiegGelfEUIcYHIU3BCqGKCEb4C_mqe7r__cCF7O3kHt8uYhmnrsxkXWMImhT5Yk6a4QDNvdj5NBdoYUj2MMPtdKCUMCYYEb-fgi60AnKOt76dw56EdYphCeQ6e9CYW_-K4r8GX95c3Fx-a609XHy_Orxvbtkw12HYCUyyE6E0nJXWKK2Gw61rPhVSOub6vI3VMKsaxkY4IJL3pCZYtsw7TNXh30B3nbufdPk02UY857Exe9GCC_vcmha3eDHe6JaJq7AXeHAXycDv7Muk6ofUxmuSHuWjcUkSVJDXcGrw9oDYPpWTfP9hgpPe16FqL_lVLZV_9neuB_N1DBV4fAVPqz_bZJBvKH05wxRkilTs7cN9C9Mv_HfX555uD9U9yf6he</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1430398288</pqid></control><display><type>article</type><title>Gut‐directed hypnotherapy significantly augments clinical remission in quiescent ulcerative colitis</title><source>MEDLINE</source><source>Wiley Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Wiley Online Library (Open Access Collection)</source><creator>Keefer, L. ; Taft, T. H. ; Kiebles, J. L. ; Martinovich, Z. ; Barrett, T. A. ; Palsson, O. S.</creator><creatorcontrib>Keefer, L. ; Taft, T. H. ; Kiebles, J. L. ; Martinovich, Z. ; Barrett, T. A. ; Palsson, O. S.</creatorcontrib><description>Summary
Background
Psychotherapy is not routinely recommended for in ulcerative colitis (UC). Gut‐directed hypnotherapy (HYP) has been linked to improved function in the gastrointestinal tract and may operate through immune‐mediated pathways in chronic diseases.
Aims
To determine the feasibility and acceptability of HYP and estimate the impact of HYP on clinical remission status over a 1‐year period in patients with an historical flare rate of 1.3 times per year.
Methods
A total of 54 patients were randomised at a single site to seven sessions of gut‐directed HYP (n = 26) or attention control (CON; n = 29) and followed for 1 year. The primary outcome was the proportion of participants in each condition that had remained clinically asymptomatic (clinical remission) through 52 weeks post treatment.
Results
One‐way analysis of variance comparing HYP and CON subjects on number of days to clinical relapse favoured the HYP condition [F = 4.8 (1, 48), P = 0.03] by 78 days. Chi‐squared analysis comparing the groups on proportion maintaining remission at 1 year was also significant [χ2(1) = 3.9, P = 0.04], with 68% of HYP and 40% of CON patients maintaining remission for 1 year. There were no significant differences between groups over time in quality of life, medication adherence, perceived stress or psychological factors.
Conclusion
This is the first prospective study that has demonstrated a significant effect of a psychological intervention on prolonging clinical remission in patients with quiescent ulcerative colitis (Clinical Trial # NCT00798642).</description><identifier>ISSN: 0269-2813</identifier><identifier>EISSN: 1365-2036</identifier><identifier>DOI: 10.1111/apt.12449</identifier><identifier>PMID: 23957526</identifier><language>eng</language><publisher>Oxford: Blackwell</publisher><subject>Adult ; Biological and medical sciences ; Colitis, Ulcerative - psychology ; Colitis, Ulcerative - therapy ; Feasibility Studies ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; Humans ; Hypnosis - methods ; Male ; Medical sciences ; Medication Adherence ; Middle Aged ; Other diseases. Semiology ; Prospective Studies ; Recurrence ; Remission Induction - methods ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Treatment Outcome</subject><ispartof>Alimentary pharmacology & therapeutics, 2013-10, Vol.38 (7), p.761-771</ispartof><rights>2013 John Wiley & Sons Ltd</rights><rights>2014 INIST-CNRS</rights><rights>2013 John Wiley & Sons Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4459-1cb7131777fab883d9697a1db4e6789d5dff269b589561a8d2708eaf21845cd13</citedby><cites>FETCH-LOGICAL-c4459-1cb7131777fab883d9697a1db4e6789d5dff269b589561a8d2708eaf21845cd13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fapt.12449$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fapt.12449$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,780,784,885,1417,1433,27924,27925,45574,45575,46409,46833</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27696502$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23957526$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Keefer, L.</creatorcontrib><creatorcontrib>Taft, T. H.</creatorcontrib><creatorcontrib>Kiebles, J. L.</creatorcontrib><creatorcontrib>Martinovich, Z.</creatorcontrib><creatorcontrib>Barrett, T. A.</creatorcontrib><creatorcontrib>Palsson, O. S.</creatorcontrib><title>Gut‐directed hypnotherapy significantly augments clinical remission in quiescent ulcerative colitis</title><title>Alimentary pharmacology & therapeutics</title><addtitle>Aliment Pharmacol Ther</addtitle><description>Summary
Background
Psychotherapy is not routinely recommended for in ulcerative colitis (UC). Gut‐directed hypnotherapy (HYP) has been linked to improved function in the gastrointestinal tract and may operate through immune‐mediated pathways in chronic diseases.
Aims
To determine the feasibility and acceptability of HYP and estimate the impact of HYP on clinical remission status over a 1‐year period in patients with an historical flare rate of 1.3 times per year.
Methods
A total of 54 patients were randomised at a single site to seven sessions of gut‐directed HYP (n = 26) or attention control (CON; n = 29) and followed for 1 year. The primary outcome was the proportion of participants in each condition that had remained clinically asymptomatic (clinical remission) through 52 weeks post treatment.
Results
One‐way analysis of variance comparing HYP and CON subjects on number of days to clinical relapse favoured the HYP condition [F = 4.8 (1, 48), P = 0.03] by 78 days. Chi‐squared analysis comparing the groups on proportion maintaining remission at 1 year was also significant [χ2(1) = 3.9, P = 0.04], with 68% of HYP and 40% of CON patients maintaining remission for 1 year. There were no significant differences between groups over time in quality of life, medication adherence, perceived stress or psychological factors.
Conclusion
This is the first prospective study that has demonstrated a significant effect of a psychological intervention on prolonging clinical remission in patients with quiescent ulcerative colitis (Clinical Trial # NCT00798642).</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Colitis, Ulcerative - psychology</subject><subject>Colitis, Ulcerative - therapy</subject><subject>Feasibility Studies</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Humans</subject><subject>Hypnosis - methods</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Medication Adherence</subject><subject>Middle Aged</subject><subject>Other diseases. Semiology</subject><subject>Prospective Studies</subject><subject>Recurrence</subject><subject>Remission Induction - methods</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><subject>Treatment Outcome</subject><issn>0269-2813</issn><issn>1365-2036</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kctu1DAYhS0EosPAghdA3iDBIq0v8W2DVFWlIFWCRVlbju3MGHmc1E6KsuMReMY-CR5mKLDAG0v253PO7wPAS4xOcV1nZpxOMWlb9QisMOWsIYjyx2CFCFcNkZiegGelfEUIcYHIU3BCqGKCEb4C_mqe7r__cCF7O3kHt8uYhmnrsxkXWMImhT5Yk6a4QDNvdj5NBdoYUj2MMPtdKCUMCYYEb-fgi60AnKOt76dw56EdYphCeQ6e9CYW_-K4r8GX95c3Fx-a609XHy_Orxvbtkw12HYCUyyE6E0nJXWKK2Gw61rPhVSOub6vI3VMKsaxkY4IJL3pCZYtsw7TNXh30B3nbufdPk02UY857Exe9GCC_vcmha3eDHe6JaJq7AXeHAXycDv7Muk6ofUxmuSHuWjcUkSVJDXcGrw9oDYPpWTfP9hgpPe16FqL_lVLZV_9neuB_N1DBV4fAVPqz_bZJBvKH05wxRkilTs7cN9C9Mv_HfX555uD9U9yf6he</recordid><startdate>201310</startdate><enddate>201310</enddate><creator>Keefer, L.</creator><creator>Taft, T. H.</creator><creator>Kiebles, J. L.</creator><creator>Martinovich, Z.</creator><creator>Barrett, T. A.</creator><creator>Palsson, O. S.</creator><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201310</creationdate><title>Gut‐directed hypnotherapy significantly augments clinical remission in quiescent ulcerative colitis</title><author>Keefer, L. ; Taft, T. H. ; Kiebles, J. L. ; Martinovich, Z. ; Barrett, T. A. ; Palsson, O. S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4459-1cb7131777fab883d9697a1db4e6789d5dff269b589561a8d2708eaf21845cd13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Colitis, Ulcerative - psychology</topic><topic>Colitis, Ulcerative - therapy</topic><topic>Feasibility Studies</topic><topic>Female</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Humans</topic><topic>Hypnosis - methods</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Medication Adherence</topic><topic>Middle Aged</topic><topic>Other diseases. Semiology</topic><topic>Prospective Studies</topic><topic>Recurrence</topic><topic>Remission Induction - methods</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Keefer, L.</creatorcontrib><creatorcontrib>Taft, T. H.</creatorcontrib><creatorcontrib>Kiebles, J. L.</creatorcontrib><creatorcontrib>Martinovich, Z.</creatorcontrib><creatorcontrib>Barrett, T. A.</creatorcontrib><creatorcontrib>Palsson, O. S.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Alimentary pharmacology & therapeutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Keefer, L.</au><au>Taft, T. H.</au><au>Kiebles, J. L.</au><au>Martinovich, Z.</au><au>Barrett, T. A.</au><au>Palsson, O. S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gut‐directed hypnotherapy significantly augments clinical remission in quiescent ulcerative colitis</atitle><jtitle>Alimentary pharmacology & therapeutics</jtitle><addtitle>Aliment Pharmacol Ther</addtitle><date>2013-10</date><risdate>2013</risdate><volume>38</volume><issue>7</issue><spage>761</spage><epage>771</epage><pages>761-771</pages><issn>0269-2813</issn><eissn>1365-2036</eissn><abstract>Summary
Background
Psychotherapy is not routinely recommended for in ulcerative colitis (UC). Gut‐directed hypnotherapy (HYP) has been linked to improved function in the gastrointestinal tract and may operate through immune‐mediated pathways in chronic diseases.
Aims
To determine the feasibility and acceptability of HYP and estimate the impact of HYP on clinical remission status over a 1‐year period in patients with an historical flare rate of 1.3 times per year.
Methods
A total of 54 patients were randomised at a single site to seven sessions of gut‐directed HYP (n = 26) or attention control (CON; n = 29) and followed for 1 year. The primary outcome was the proportion of participants in each condition that had remained clinically asymptomatic (clinical remission) through 52 weeks post treatment.
Results
One‐way analysis of variance comparing HYP and CON subjects on number of days to clinical relapse favoured the HYP condition [F = 4.8 (1, 48), P = 0.03] by 78 days. Chi‐squared analysis comparing the groups on proportion maintaining remission at 1 year was also significant [χ2(1) = 3.9, P = 0.04], with 68% of HYP and 40% of CON patients maintaining remission for 1 year. There were no significant differences between groups over time in quality of life, medication adherence, perceived stress or psychological factors.
Conclusion
This is the first prospective study that has demonstrated a significant effect of a psychological intervention on prolonging clinical remission in patients with quiescent ulcerative colitis (Clinical Trial # NCT00798642).</abstract><cop>Oxford</cop><pub>Blackwell</pub><pmid>23957526</pmid><doi>10.1111/apt.12449</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Wiley Journals; EZB-FREE-00999 freely available EZB journals; Wiley Online Library (Open Access Collection) |
| subjects | Adult Biological and medical sciences Colitis, Ulcerative - psychology Colitis, Ulcerative - therapy Feasibility Studies Female Gastroenterology. Liver. Pancreas. Abdomen Humans Hypnosis - methods Male Medical sciences Medication Adherence Middle Aged Other diseases. Semiology Prospective Studies Recurrence Remission Induction - methods Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Treatment Outcome |
| title | Gut‐directed hypnotherapy significantly augments clinical remission in quiescent ulcerative colitis |
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