Interleukin-17 inhibits Adult Hippocampal Neurogenesis

Interleukin 17(A) (IL-17) is a potent pro-inflammatory cytokine that acts as a central regulator of inflammatory response within the brain, but its physiological roles under non-inflammatory conditions remain elusive. Here we report that endogenous IL-17 ablates neurogenesis in the adult dentate gyr...

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Veröffentlicht in:	Scientific reports 2014-12, Vol.4 (1), p.7554-7554
Hauptverfasser:	Liu, Qiang, Xin, Wei, He, Ping, Turner, Dharshaun, Yin, Junxiang, Gan, Yan, Shi, Fu-Dong, Wu, Jie
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/100 13/105 13/106 13/21 13/31 631/378/371 631/378/87 Animals Clonal deletion Cytokines Dentate gyrus Dentate Gyrus - cytology Dentate Gyrus - growth & development Excitability Gene Deletion Hippocampus Humanities and Social Sciences Inflammation Interleukin 17 Interleukin-17 - genetics Interleukin-17 - metabolism Mice Mice, Knockout multidisciplinary Neural stem cells Neural Stem Cells - cytology Neural Stem Cells - metabolism Neurogenesis Neurogenesis - physiology Physiology Science Synaptic transmission Synaptic Transmission - physiology
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