Interleukin-17 inhibits Adult Hippocampal Neurogenesis
Interleukin 17(A) (IL-17) is a potent pro-inflammatory cytokine that acts as a central regulator of inflammatory response within the brain, but its physiological roles under non-inflammatory conditions remain elusive. Here we report that endogenous IL-17 ablates neurogenesis in the adult dentate gyr...
Gespeichert in:
| Veröffentlicht in: | Scientific reports 2014-12, Vol.4 (1), p.7554-7554 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 7554 |
|---|---|
| container_issue | 1 |
| container_start_page | 7554 |
| container_title | Scientific reports |
| container_volume | 4 |
| creator | Liu, Qiang Xin, Wei He, Ping Turner, Dharshaun Yin, Junxiang Gan, Yan Shi, Fu-Dong Wu, Jie |
| description | Interleukin 17(A) (IL-17) is a potent pro-inflammatory cytokine that acts as a central regulator of inflammatory response within the brain, but its physiological roles under non-inflammatory conditions remain elusive. Here we report that endogenous IL-17 ablates neurogenesis in the adult dentate gyrus (DG) of hippocampus. Genetic deletion of IL-17 increased the number of adult-born neurons in the DG. Further, we found that IL-17 deletion altered cytokine network, facilitated basal excitatory synaptic transmission, enhanced intrinsic neuronal excitability and increased expression of proneuronal genes in neuronal progenitor cells (NPCs). Our findings suggest a profound role of IL-17 in the negative regulation of adult hippocampal neurogenesis under physiology conditions. |
| doi_str_mv | 10.1038/srep07554 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4271266</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1639979952</sourcerecordid><originalsourceid>FETCH-LOGICAL-p259t-792fe06b8565546e54ab58fe882e8d71a1665987421cd25b3af5a4ff6b0c97883</originalsourceid><addsrcrecordid>eNpdkU9Lw0AQxRdBbKk9-AUk4EWE6O4m--8ilKK2UPSi52WTTNqtySbuJoLf3pRWqc5lDvP48eY9hC4IviU4kXfBQ4sFY-kJGlOcspgmlI7QNIQtHoZRlRJ1hkaUMZpgScaIL10HvoL-3bqYiMi6jc1sF6JZ0VddtLBt2-Smbk0VPUPvmzU4CDaco9PSVAGmhz1Bb48Pr_NFvHp5Ws5nq7ilTHWxULQEzDPJ-GCKA0tNxmQJUlKQhSCGcM6UFCkleUFZlpiSmbQseYZzJaRMJuh-z237rIYiB9d5U-nW29r4L90Yq_9enN3odfOpUyoI5XwAXB8AvvnoIXS6tiGHqjIOmj5owhOlhFJDHhN09U-6bXrvhvc0kUoSkaRqB7w8dvRr5SfSQXCzF4Th5NbgjzBY72rSvzUl3z3zhAg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1898173496</pqid></control><display><type>article</type><title>Interleukin-17 inhibits Adult Hippocampal Neurogenesis</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Springer Nature OA Free Journals</source><source>Nature Free</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><creator>Liu, Qiang ; Xin, Wei ; He, Ping ; Turner, Dharshaun ; Yin, Junxiang ; Gan, Yan ; Shi, Fu-Dong ; Wu, Jie</creator><creatorcontrib>Liu, Qiang ; Xin, Wei ; He, Ping ; Turner, Dharshaun ; Yin, Junxiang ; Gan, Yan ; Shi, Fu-Dong ; Wu, Jie</creatorcontrib><description>Interleukin 17(A) (IL-17) is a potent pro-inflammatory cytokine that acts as a central regulator of inflammatory response within the brain, but its physiological roles under non-inflammatory conditions remain elusive. Here we report that endogenous IL-17 ablates neurogenesis in the adult dentate gyrus (DG) of hippocampus. Genetic deletion of IL-17 increased the number of adult-born neurons in the DG. Further, we found that IL-17 deletion altered cytokine network, facilitated basal excitatory synaptic transmission, enhanced intrinsic neuronal excitability and increased expression of proneuronal genes in neuronal progenitor cells (NPCs). Our findings suggest a profound role of IL-17 in the negative regulation of adult hippocampal neurogenesis under physiology conditions.</description><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/srep07554</identifier><identifier>PMID: 25523081</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>13 ; 13/100 ; 13/105 ; 13/106 ; 13/21 ; 13/31 ; 631/378/371 ; 631/378/87 ; Animals ; Clonal deletion ; Cytokines ; Dentate gyrus ; Dentate Gyrus - cytology ; Dentate Gyrus - growth & development ; Excitability ; Gene Deletion ; Hippocampus ; Humanities and Social Sciences ; Inflammation ; Interleukin 17 ; Interleukin-17 - genetics ; Interleukin-17 - metabolism ; Mice ; Mice, Knockout ; multidisciplinary ; Neural stem cells ; Neural Stem Cells - cytology ; Neural Stem Cells - metabolism ; Neurogenesis ; Neurogenesis - physiology ; Physiology ; Science ; Synaptic transmission ; Synaptic Transmission - physiology</subject><ispartof>Scientific reports, 2014-12, Vol.4 (1), p.7554-7554</ispartof><rights>The Author(s) 2014</rights><rights>Copyright Nature Publishing Group Dec 2014</rights><rights>Copyright © 2014, Macmillan Publishers Limited. All rights reserved 2014 Macmillan Publishers Limited. All rights reserved</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-p259t-792fe06b8565546e54ab58fe882e8d71a1665987421cd25b3af5a4ff6b0c97883</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4271266/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4271266/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27923,27924,41119,42188,51575,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25523081$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Qiang</creatorcontrib><creatorcontrib>Xin, Wei</creatorcontrib><creatorcontrib>He, Ping</creatorcontrib><creatorcontrib>Turner, Dharshaun</creatorcontrib><creatorcontrib>Yin, Junxiang</creatorcontrib><creatorcontrib>Gan, Yan</creatorcontrib><creatorcontrib>Shi, Fu-Dong</creatorcontrib><creatorcontrib>Wu, Jie</creatorcontrib><title>Interleukin-17 inhibits Adult Hippocampal Neurogenesis</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>Interleukin 17(A) (IL-17) is a potent pro-inflammatory cytokine that acts as a central regulator of inflammatory response within the brain, but its physiological roles under non-inflammatory conditions remain elusive. Here we report that endogenous IL-17 ablates neurogenesis in the adult dentate gyrus (DG) of hippocampus. Genetic deletion of IL-17 increased the number of adult-born neurons in the DG. Further, we found that IL-17 deletion altered cytokine network, facilitated basal excitatory synaptic transmission, enhanced intrinsic neuronal excitability and increased expression of proneuronal genes in neuronal progenitor cells (NPCs). Our findings suggest a profound role of IL-17 in the negative regulation of adult hippocampal neurogenesis under physiology conditions.</description><subject>13</subject><subject>13/100</subject><subject>13/105</subject><subject>13/106</subject><subject>13/21</subject><subject>13/31</subject><subject>631/378/371</subject><subject>631/378/87</subject><subject>Animals</subject><subject>Clonal deletion</subject><subject>Cytokines</subject><subject>Dentate gyrus</subject><subject>Dentate Gyrus - cytology</subject><subject>Dentate Gyrus - growth & development</subject><subject>Excitability</subject><subject>Gene Deletion</subject><subject>Hippocampus</subject><subject>Humanities and Social Sciences</subject><subject>Inflammation</subject><subject>Interleukin 17</subject><subject>Interleukin-17 - genetics</subject><subject>Interleukin-17 - metabolism</subject><subject>Mice</subject><subject>Mice, Knockout</subject><subject>multidisciplinary</subject><subject>Neural stem cells</subject><subject>Neural Stem Cells - cytology</subject><subject>Neural Stem Cells - metabolism</subject><subject>Neurogenesis</subject><subject>Neurogenesis - physiology</subject><subject>Physiology</subject><subject>Science</subject><subject>Synaptic transmission</subject><subject>Synaptic Transmission - physiology</subject><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNpdkU9Lw0AQxRdBbKk9-AUk4EWE6O4m--8ilKK2UPSi52WTTNqtySbuJoLf3pRWqc5lDvP48eY9hC4IviU4kXfBQ4sFY-kJGlOcspgmlI7QNIQtHoZRlRJ1hkaUMZpgScaIL10HvoL-3bqYiMi6jc1sF6JZ0VddtLBt2-Smbk0VPUPvmzU4CDaco9PSVAGmhz1Bb48Pr_NFvHp5Ws5nq7ilTHWxULQEzDPJ-GCKA0tNxmQJUlKQhSCGcM6UFCkleUFZlpiSmbQseYZzJaRMJuh-z237rIYiB9d5U-nW29r4L90Yq_9enN3odfOpUyoI5XwAXB8AvvnoIXS6tiGHqjIOmj5owhOlhFJDHhN09U-6bXrvhvc0kUoSkaRqB7w8dvRr5SfSQXCzF4Th5NbgjzBY72rSvzUl3z3zhAg</recordid><startdate>20141219</startdate><enddate>20141219</enddate><creator>Liu, Qiang</creator><creator>Xin, Wei</creator><creator>He, Ping</creator><creator>Turner, Dharshaun</creator><creator>Yin, Junxiang</creator><creator>Gan, Yan</creator><creator>Shi, Fu-Dong</creator><creator>Wu, Jie</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20141219</creationdate><title>Interleukin-17 inhibits Adult Hippocampal Neurogenesis</title><author>Liu, Qiang ; Xin, Wei ; He, Ping ; Turner, Dharshaun ; Yin, Junxiang ; Gan, Yan ; Shi, Fu-Dong ; Wu, Jie</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p259t-792fe06b8565546e54ab58fe882e8d71a1665987421cd25b3af5a4ff6b0c97883</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>13</topic><topic>13/100</topic><topic>13/105</topic><topic>13/106</topic><topic>13/21</topic><topic>13/31</topic><topic>631/378/371</topic><topic>631/378/87</topic><topic>Animals</topic><topic>Clonal deletion</topic><topic>Cytokines</topic><topic>Dentate gyrus</topic><topic>Dentate Gyrus - cytology</topic><topic>Dentate Gyrus - growth & development</topic><topic>Excitability</topic><topic>Gene Deletion</topic><topic>Hippocampus</topic><topic>Humanities and Social Sciences</topic><topic>Inflammation</topic><topic>Interleukin 17</topic><topic>Interleukin-17 - genetics</topic><topic>Interleukin-17 - metabolism</topic><topic>Mice</topic><topic>Mice, Knockout</topic><topic>multidisciplinary</topic><topic>Neural stem cells</topic><topic>Neural Stem Cells - cytology</topic><topic>Neural Stem Cells - metabolism</topic><topic>Neurogenesis</topic><topic>Neurogenesis - physiology</topic><topic>Physiology</topic><topic>Science</topic><topic>Synaptic transmission</topic><topic>Synaptic Transmission - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Qiang</creatorcontrib><creatorcontrib>Xin, Wei</creatorcontrib><creatorcontrib>He, Ping</creatorcontrib><creatorcontrib>Turner, Dharshaun</creatorcontrib><creatorcontrib>Yin, Junxiang</creatorcontrib><creatorcontrib>Gan, Yan</creatorcontrib><creatorcontrib>Shi, Fu-Dong</creatorcontrib><creatorcontrib>Wu, Jie</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Qiang</au><au>Xin, Wei</au><au>He, Ping</au><au>Turner, Dharshaun</au><au>Yin, Junxiang</au><au>Gan, Yan</au><au>Shi, Fu-Dong</au><au>Wu, Jie</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Interleukin-17 inhibits Adult Hippocampal Neurogenesis</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2014-12-19</date><risdate>2014</risdate><volume>4</volume><issue>1</issue><spage>7554</spage><epage>7554</epage><pages>7554-7554</pages><eissn>2045-2322</eissn><abstract>Interleukin 17(A) (IL-17) is a potent pro-inflammatory cytokine that acts as a central regulator of inflammatory response within the brain, but its physiological roles under non-inflammatory conditions remain elusive. Here we report that endogenous IL-17 ablates neurogenesis in the adult dentate gyrus (DG) of hippocampus. Genetic deletion of IL-17 increased the number of adult-born neurons in the DG. Further, we found that IL-17 deletion altered cytokine network, facilitated basal excitatory synaptic transmission, enhanced intrinsic neuronal excitability and increased expression of proneuronal genes in neuronal progenitor cells (NPCs). Our findings suggest a profound role of IL-17 in the negative regulation of adult hippocampal neurogenesis under physiology conditions.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>25523081</pmid><doi>10.1038/srep07554</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | EISSN: 2045-2322 |
| ispartof | Scientific reports, 2014-12, Vol.4 (1), p.7554-7554 |
| issn | 2045-2322 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4271266 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Springer Nature OA Free Journals; Nature Free; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | 13 13/100 13/105 13/106 13/21 13/31 631/378/371 631/378/87 Animals Clonal deletion Cytokines Dentate gyrus Dentate Gyrus - cytology Dentate Gyrus - growth & development Excitability Gene Deletion Hippocampus Humanities and Social Sciences Inflammation Interleukin 17 Interleukin-17 - genetics Interleukin-17 - metabolism Mice Mice, Knockout multidisciplinary Neural stem cells Neural Stem Cells - cytology Neural Stem Cells - metabolism Neurogenesis Neurogenesis - physiology Physiology Science Synaptic transmission Synaptic Transmission - physiology |
| title | Interleukin-17 inhibits Adult Hippocampal Neurogenesis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-12T22%3A59%3A08IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Interleukin-17%20inhibits%20Adult%20Hippocampal%20Neurogenesis&rft.jtitle=Scientific%20reports&rft.au=Liu,%20Qiang&rft.date=2014-12-19&rft.volume=4&rft.issue=1&rft.spage=7554&rft.epage=7554&rft.pages=7554-7554&rft.eissn=2045-2322&rft_id=info:doi/10.1038/srep07554&rft_dat=%3Cproquest_pubme%3E1639979952%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1898173496&rft_id=info:pmid/25523081&rfr_iscdi=true |