The Anti-proliferative Function of the TGF-β1 Signaling Pathway Involves the Repression of the Oncogenic TBX2 by Its Homologue TBX3

A growing body of work has shown that the highly homologous T-box transcription factors TBX2 and TBX3 play critical but distinct roles in embryonic development and cancer progression. For example, TBX2 and TBX3 are up-regulated in several cancers and recent evidence suggests that whereas TBX2 functi...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of biological chemistry 2014-12, Vol.289 (51), p.35633-35643
Hauptverfasser:	Li, Jarod, Ballim, Deeya, Rodriguez, Mercedes, Cui, Rutao, Goding, Colin R., Teng, Huajian, Prince, Sharon
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding Sites - genetics Blotting, Western Cell Cycle Cell Line Cell Line, Tumor Cell Proliferation Cell Proliferation - drug effects Down-Regulation - drug effects Gene Expression Gene Expression - drug effects Gene Regulation Humans Mutation Oncogene Proteins - genetics Oncogene Proteins - metabolism p21 Promoter Regions, Genetic - genetics Protein Binding - drug effects Reverse Transcriptase Polymerase Chain Reaction RNA Interference Signal Transduction - genetics T-Box Domain Proteins - genetics T-Box Domain Proteins - metabolism TBX2 TBX3 Transcription Factor Transforming Growth Factor beta1 - pharmacology Transforming Growth Factor β (TGF-β)
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!