Regulated Apoptosis of Genetically Modified Hematopoietic Stem and Progenitor Cells Via an Inducible Caspase‐9 Suicide Gene in Rhesus Macaques

The high risk of insertional oncogenesis reported in clinical trials using integrating retroviral vectors to genetically modify hematopoietic stem and progenitor cells (HSPCs) requires the development of safety strategies to minimize risks associated with novel cell and gene therapies. The ability t...

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Veröffentlicht in:	Stem cells (Dayton, Ohio) Ohio), 2015-01, Vol.33 (1), p.91-100
Hauptverfasser:	Barese, Cecilia N., Felizardo, Tania C., Sellers, Stephanie E., Keyvanfar, Keyvan, Di Stasi, Antonio, Metzger, Mark E., Krouse, Allen E., Donahue, Robert E., Spencer, David M., Dunbar, Cynthia E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - physiology Caspase 9 - biosynthesis Caspase 9 - genetics Gene therapy Genes Genes, Transgenic, Suicide Genetic Therapy Genetic Vectors Genotoxicity Hematopoietic Stem Cell Transplantation - methods Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - enzymology HSC transplantation iCasp9 Macaca mulatta Medical research Primates Stem cells Suicide gene
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