Biomonitoring and Hormone‐Disrupting Effect Biomarkers of Persistent Organic Pollutants In Vitro and Ex Vivo
Persistent organic pollutants (POPs) include lipophilic legacy POPs and the amphiphilic perfluorinated alkyl acids (PFAAs). They have long half‐lives and bioaccumulate in the environment, animals and human beings. POPs possess toxic, carcinogenic and endocrine‐disrupting potentials. Endocrine‐disrup...
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| Veröffentlicht in: | Basic & clinical pharmacology & toxicology 2014-07, Vol.115 (1), p.118-128 |
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| creator | Bonefeld‐Jørgensen, Eva C. Ghisari, Mandana Wielsøe, Maria Bjerregaard‐Olesen, Christian Kjeldsen, Lisbeth S. Long, Manhai |
| description | Persistent organic pollutants (POPs) include lipophilic legacy POPs and the amphiphilic perfluorinated alkyl acids (PFAAs). They have long half‐lives and bioaccumulate in the environment, animals and human beings. POPs possess toxic, carcinogenic and endocrine‐disrupting potentials. Endocrine‐disrupting chemicals (EDCs) are compounds that either mimic or block endogenous hormones and thus disrupt the normal hormone homeostasis. Biomonitoring assesses the internal doses of a person to provide information about chemical exposures. Effect biomarkers assess chemicals potential to affect cellular functions in vivo/ex vivo. Human beings are exposed to complex mixtures of chemicals, having individually very different biological potentials and effects. Therefore, the assessment of the combined, integrated biological effect of the actual chemical mixture in human blood is important. In vitro and ex vivo cell systems have been introduced for the assessment of the integrated level of xenobiotic cellular effects in human beings. Ex vivo studies have shown geographical differences in bioaccumulated POP serum levels, being reflected by the combined biomarker effects of the complex mixture extracted from human serum. Xenohormone receptor transactivities can be used as an ex vivo integrated biomarker of POP exposure and effects. Epidemiological and in vitro/ex vivo studies have supported the potential impact of the combined effect of serum POPs on the activity of hormone and/or dioxin receptors as a risk factor for human health. With focus on hormone disruption, this MiniReview will give an update on recent POP‐related endocrine‐disrupting effects in vitro/ex vivo/in vivo and some related genetic data. |
| doi_str_mv | 10.1111/bcpt.12263 |
| format | Article |
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They have long half‐lives and bioaccumulate in the environment, animals and human beings. POPs possess toxic, carcinogenic and endocrine‐disrupting potentials. Endocrine‐disrupting chemicals (EDCs) are compounds that either mimic or block endogenous hormones and thus disrupt the normal hormone homeostasis. Biomonitoring assesses the internal doses of a person to provide information about chemical exposures. Effect biomarkers assess chemicals potential to affect cellular functions in vivo/ex vivo. Human beings are exposed to complex mixtures of chemicals, having individually very different biological potentials and effects. Therefore, the assessment of the combined, integrated biological effect of the actual chemical mixture in human blood is important. In vitro and ex vivo cell systems have been introduced for the assessment of the integrated level of xenobiotic cellular effects in human beings. Ex vivo studies have shown geographical differences in bioaccumulated POP serum levels, being reflected by the combined biomarker effects of the complex mixture extracted from human serum. Xenohormone receptor transactivities can be used as an ex vivo integrated biomarker of POP exposure and effects. Epidemiological and in vitro/ex vivo studies have supported the potential impact of the combined effect of serum POPs on the activity of hormone and/or dioxin receptors as a risk factor for human health. With focus on hormone disruption, this MiniReview will give an update on recent POP‐related endocrine‐disrupting effects in vitro/ex vivo/in vivo and some related genetic data.</description><identifier>ISSN: 1742-7835</identifier><identifier>EISSN: 1742-7843</identifier><identifier>DOI: 10.1111/bcpt.12263</identifier><identifier>PMID: 24797035</identifier><language>eng</language><publisher>Oxford: Blackwell</publisher><subject>Animals ; Biological and medical sciences ; Biomarkers ; Biomarkers - blood ; Chemicals ; Endocrine Disruptors - blood ; Endocrine Disruptors - toxicity ; Endocrine system ; Environmental Monitoring - methods ; Environmental Pollutants - blood ; Environmental Pollutants - toxicity ; Humans ; Medical sciences ; Minireviews ; Pharmacology. Drug treatments ; Pollutants ; Polychlorinated Biphenyls - blood ; Polychlorinated Biphenyls - toxicity ; Polychlorinated Dibenzodioxins - analogs & derivatives ; Polychlorinated Dibenzodioxins - blood ; Polychlorinated Dibenzodioxins - toxicity ; Xenobiotics - blood ; Xenobiotics - toxicity</subject><ispartof>Basic & clinical pharmacology & toxicology, 2014-07, Vol.115 (1), p.118-128</ispartof><rights>2014 The Authors. Basic & Clinical Pharmacology & Toxicology published by John Wiley & Sons Ltd on behalf of Nordic Association for the Publication of BCPT (former Nordic Pharmacological Society).</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2014 Nordic Association for the Publication of BCPT (former Nordic Pharmacological Society). Published by John Wiley & Sons Ltd</rights><rights>2014 The Authors. Basic & Clinical Pharmacology & Toxicology published by John Wiley & Sons Ltd on behalf of Nordic Association for the Publication of BCPT (former Nordic Pharmacological Society). 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5113-5cce8d123c3a1fffdd5bdfcdb998c24c2709489b125b16b75b7f4090492c09283</citedby><cites>FETCH-LOGICAL-c5113-5cce8d123c3a1fffdd5bdfcdb998c24c2709489b125b16b75b7f4090492c09283</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fbcpt.12263$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fbcpt.12263$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>230,309,310,314,780,784,789,790,885,1417,23930,23931,25140,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28535644$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24797035$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bonefeld‐Jørgensen, Eva C.</creatorcontrib><creatorcontrib>Ghisari, Mandana</creatorcontrib><creatorcontrib>Wielsøe, Maria</creatorcontrib><creatorcontrib>Bjerregaard‐Olesen, Christian</creatorcontrib><creatorcontrib>Kjeldsen, Lisbeth S.</creatorcontrib><creatorcontrib>Long, Manhai</creatorcontrib><title>Biomonitoring and Hormone‐Disrupting Effect Biomarkers of Persistent Organic Pollutants In Vitro and Ex Vivo</title><title>Basic & clinical pharmacology & toxicology</title><addtitle>Basic Clin Pharmacol Toxicol</addtitle><description>Persistent organic pollutants (POPs) include lipophilic legacy POPs and the amphiphilic perfluorinated alkyl acids (PFAAs). 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Ex vivo studies have shown geographical differences in bioaccumulated POP serum levels, being reflected by the combined biomarker effects of the complex mixture extracted from human serum. Xenohormone receptor transactivities can be used as an ex vivo integrated biomarker of POP exposure and effects. Epidemiological and in vitro/ex vivo studies have supported the potential impact of the combined effect of serum POPs on the activity of hormone and/or dioxin receptors as a risk factor for human health. 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Drug treatments</subject><subject>Pollutants</subject><subject>Polychlorinated Biphenyls - blood</subject><subject>Polychlorinated Biphenyls - toxicity</subject><subject>Polychlorinated Dibenzodioxins - analogs & derivatives</subject><subject>Polychlorinated Dibenzodioxins - blood</subject><subject>Polychlorinated Dibenzodioxins - toxicity</subject><subject>Xenobiotics - blood</subject><subject>Xenobiotics - toxicity</subject><issn>1742-7835</issn><issn>1742-7843</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><sourceid>EIF</sourceid><recordid>eNp9kd1KHDEYhoNU1KonXoAESqEUVvO7M3Mi1O36A4J7oJ6GTCZZo7PJmmRsPesl9Bp7Jc2469Z6YCB8Sb6H93vDC8AeRgc4r8NazdMBJmRI18AWLhgZFCWjH1ZnyjfBxxjvECIFw2gDbBJWVAWifAu4Y-tn3tnkg3VTKF0Dz3zIL_rPr9_fbQzdPPWNsTFaJdjTMtzrEKE3cJKrjUm7BC_DVDqr4MS3bZekSxGeO3hjU_DPouOf-fLod8C6kW3Uu8u6Da5Pxlejs8HF5en56NvFQHGM6YArpcsGE6qoxMaYpuF1Y1RTV1WpCFOkQBUrqxoTXuNhXfC6MAxViFVEoYqUdBscLXTnXT3TjcoWg2zFPNhs_0l4acX_HWdvxdQ_CpalCR9mgS9LgeAfOh2TmNmodNtKp30XBeYMEZI3zuinN-id74LL38sUZagsEWeZ-rqgVPAxBm1WZjASfYyij1E8x5jh_df2V-hLbhn4vARkVLI1QTpl4z-u5JQPWT8VL7gfttVP74wUx6PJ1WL4XxkKtzU</recordid><startdate>201407</startdate><enddate>201407</enddate><creator>Bonefeld‐Jørgensen, Eva C.</creator><creator>Ghisari, Mandana</creator><creator>Wielsøe, Maria</creator><creator>Bjerregaard‐Olesen, Christian</creator><creator>Kjeldsen, Lisbeth S.</creator><creator>Long, Manhai</creator><general>Blackwell</general><general>Wiley Subscription Services, Inc</general><general>BlackWell Publishing Ltd</general><scope>24P</scope><scope>WIN</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>7U7</scope><scope>C1K</scope><scope>7T2</scope><scope>7TV</scope><scope>7U1</scope><scope>7U2</scope><scope>5PM</scope></search><sort><creationdate>201407</creationdate><title>Biomonitoring and Hormone‐Disrupting Effect Biomarkers of Persistent Organic Pollutants In Vitro and Ex Vivo</title><author>Bonefeld‐Jørgensen, Eva C. ; Ghisari, Mandana ; Wielsøe, Maria ; Bjerregaard‐Olesen, Christian ; Kjeldsen, Lisbeth S. ; Long, Manhai</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5113-5cce8d123c3a1fffdd5bdfcdb998c24c2709489b125b16b75b7f4090492c09283</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Biomarkers</topic><topic>Biomarkers - blood</topic><topic>Chemicals</topic><topic>Endocrine Disruptors - blood</topic><topic>Endocrine Disruptors - toxicity</topic><topic>Endocrine system</topic><topic>Environmental Monitoring - methods</topic><topic>Environmental Pollutants - blood</topic><topic>Environmental Pollutants - toxicity</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Minireviews</topic><topic>Pharmacology. 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| subjects | Animals Biological and medical sciences Biomarkers Biomarkers - blood Chemicals Endocrine Disruptors - blood Endocrine Disruptors - toxicity Endocrine system Environmental Monitoring - methods Environmental Pollutants - blood Environmental Pollutants - toxicity Humans Medical sciences Minireviews Pharmacology. Drug treatments Pollutants Polychlorinated Biphenyls - blood Polychlorinated Biphenyls - toxicity Polychlorinated Dibenzodioxins - analogs & derivatives Polychlorinated Dibenzodioxins - blood Polychlorinated Dibenzodioxins - toxicity Xenobiotics - blood Xenobiotics - toxicity |
| title | Biomonitoring and Hormone‐Disrupting Effect Biomarkers of Persistent Organic Pollutants In Vitro and Ex Vivo |
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