The usefulness of clinical and laboratory parameters for predicting severity of dehydration in children with acute gastroenteritis
An accurate assessment of the degree of dehydration in infants and children is important for proper decision-making and treatment. This emphasizes the need for laboratory tests to improve the accuracy of clinical assessment of dehydration. The aim of this study was to assess the relationship between...
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| Veröffentlicht in: | Medicinski arhiv 2014-10, Vol.68 (5), p.304-307 |
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| creator | Hoxha, Teuta Faik Azemi, Mehmedali Avdiu, Muharrem Ismaili-Jaha, Vlora Grajqevci, Violeta Petrela, Ela |
| description | An accurate assessment of the degree of dehydration in infants and children is important for proper decision-making and treatment. This emphasizes the need for laboratory tests to improve the accuracy of clinical assessment of dehydration. The aim of this study was to assess the relationship between clinical and laboratory parameters in the assessment of dehydration.
We evaluated prospectively 200 children aged 1 month to 5 years who presented with diarrhea, vomiting or both. Dehydration assessment was done following a known clinical scheme.
We enrolled in the study 200 children (57.5% were male). The mean age was 15.62±9.03 months, with more than half those studied being under 24 months old. Overall, 46.5% (93) had mild dehydration, 34% (68) had moderate dehydration, 5.5% (11) had severe dehydration whereas, 14% (28) had no dehydration. Patients historical clinical variables in all dehydration groups did not differ significantly regarding age, sex, fever, frequency of vomiting, duration of diarrhea and vomiting, while there was a trend toward severe dehydration in children with more frequent diarrhea (p=0.004). Serum urea and creatinine cannot discriminate between mild and moderate dehydration but they showed a good specificity for severe dehydration of 99% and 100% respectively. Serum bicarbonates and base excess decreased significantly with a degree of dehydration and can discriminate between all dehydration groups (P |
| doi_str_mv | 10.5455/medarh.2014.68.304-307 |
| format | Article |
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We evaluated prospectively 200 children aged 1 month to 5 years who presented with diarrhea, vomiting or both. Dehydration assessment was done following a known clinical scheme.
We enrolled in the study 200 children (57.5% were male). The mean age was 15.62±9.03 months, with more than half those studied being under 24 months old. Overall, 46.5% (93) had mild dehydration, 34% (68) had moderate dehydration, 5.5% (11) had severe dehydration whereas, 14% (28) had no dehydration. Patients historical clinical variables in all dehydration groups did not differ significantly regarding age, sex, fever, frequency of vomiting, duration of diarrhea and vomiting, while there was a trend toward severe dehydration in children with more frequent diarrhea (p=0.004). Serum urea and creatinine cannot discriminate between mild and moderate dehydration but they showed a good specificity for severe dehydration of 99% and 100% respectively. Serum bicarbonates and base excess decreased significantly with a degree of dehydration and can discriminate between all dehydration groups (P<0.001).
Blood gases were useful to diagnose the degree of dehydration status among children presenting with acute gastroenteritis. Serum urea and creatinine were the most specific tests for severe dehydration diagnosis. Historical clinical patterns apart from frequency of diarrhea did not correlate with dehydration status. Further studies are needed to validate our results.</description><identifier>ISSN: 0350-199X</identifier><identifier>EISSN: 1986-5961</identifier><identifier>DOI: 10.5455/medarh.2014.68.304-307</identifier><identifier>PMID: 25568559</identifier><language>eng</language><publisher>Bosnia and Herzegovina: Academy of Medical Sciences of Bosnia and Herzegovina</publisher><subject>Acute Disease ; Blood Gas Analysis ; Child, Preschool ; Creatinine - blood ; Dehydration - diagnosis ; Female ; Gastroenteritis - complications ; Humans ; Infant ; Male ; Monitoring, Physiologic - methods ; Original ; Predictive Value of Tests ; Severity of Illness Index ; Urea - blood</subject><ispartof>Medicinski arhiv, 2014-10, Vol.68 (5), p.304-307</ispartof><rights>Copyright Academy of Medical Sciences of Bosnia and Herzegovina 2014</rights><rights>Copyright: © AVICENA 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3577-84d581b0caa68f58b8df6f3f27f6bc966fdcdb4d8a5d76112b4a29b9c628c55c3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4269529/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4269529/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25568559$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hoxha, Teuta Faik</creatorcontrib><creatorcontrib>Azemi, Mehmedali</creatorcontrib><creatorcontrib>Avdiu, Muharrem</creatorcontrib><creatorcontrib>Ismaili-Jaha, Vlora</creatorcontrib><creatorcontrib>Grajqevci, Violeta</creatorcontrib><creatorcontrib>Petrela, Ela</creatorcontrib><title>The usefulness of clinical and laboratory parameters for predicting severity of dehydration in children with acute gastroenteritis</title><title>Medicinski arhiv</title><addtitle>Med Arch</addtitle><description>An accurate assessment of the degree of dehydration in infants and children is important for proper decision-making and treatment. This emphasizes the need for laboratory tests to improve the accuracy of clinical assessment of dehydration. The aim of this study was to assess the relationship between clinical and laboratory parameters in the assessment of dehydration.
We evaluated prospectively 200 children aged 1 month to 5 years who presented with diarrhea, vomiting or both. Dehydration assessment was done following a known clinical scheme.
We enrolled in the study 200 children (57.5% were male). The mean age was 15.62±9.03 months, with more than half those studied being under 24 months old. Overall, 46.5% (93) had mild dehydration, 34% (68) had moderate dehydration, 5.5% (11) had severe dehydration whereas, 14% (28) had no dehydration. Patients historical clinical variables in all dehydration groups did not differ significantly regarding age, sex, fever, frequency of vomiting, duration of diarrhea and vomiting, while there was a trend toward severe dehydration in children with more frequent diarrhea (p=0.004). Serum urea and creatinine cannot discriminate between mild and moderate dehydration but they showed a good specificity for severe dehydration of 99% and 100% respectively. Serum bicarbonates and base excess decreased significantly with a degree of dehydration and can discriminate between all dehydration groups (P<0.001).
Blood gases were useful to diagnose the degree of dehydration status among children presenting with acute gastroenteritis. Serum urea and creatinine were the most specific tests for severe dehydration diagnosis. Historical clinical patterns apart from frequency of diarrhea did not correlate with dehydration status. Further studies are needed to validate our results.</description><subject>Acute Disease</subject><subject>Blood Gas Analysis</subject><subject>Child, Preschool</subject><subject>Creatinine - blood</subject><subject>Dehydration - diagnosis</subject><subject>Female</subject><subject>Gastroenteritis - complications</subject><subject>Humans</subject><subject>Infant</subject><subject>Male</subject><subject>Monitoring, Physiologic - methods</subject><subject>Original</subject><subject>Predictive Value of Tests</subject><subject>Severity of Illness Index</subject><subject>Urea - blood</subject><issn>0350-199X</issn><issn>1986-5961</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNpdkUuLFDEUhYMoTjv6F4aAGzfVJqk8N4IMvmDAzQjuQiqPrgzVSZukRnrrLzdNj4O6uGRxv3M4NweAK4y2jDL2du-dKfOWIEy3XG5HRIcRiSdgg5XkA1McPwUbNDI0YKW-X4AXtd4hxJQg6jm4IIxxyZjagF-3s4dr9WFdkq8V5gDtElO0ZoEmObiYKRfTcjnCgylm75svFYZc4KF4F22LaQerv_cltuNJ7fx8dF0Rc4IxQTvHxRWf4M_YZmjs2jzcmdpK9qmdRLG-BM-CWap_9fBegm8fP9xefx5uvn76cv3-ZrAjE2KQ1DGJJ2SN4TIwOUkXeBgDEYFPVnEenHUTddIwJzjGZKKGqElZTqRlzI6X4N3Z97BO_ftsD1DMog8l7k056myi_neT4qx3-V5TwhUjqhu8eTAo-cfqa9P7WK1fFpN8XqvGnPagQmDU0df_oXd5Lamf16nOUamU7BQ_U7bkWosPj2Ew0qea9blmfapZc6l7zX1EF179fcqj7E-v42_C_KqK</recordid><startdate>20141001</startdate><enddate>20141001</enddate><creator>Hoxha, Teuta Faik</creator><creator>Azemi, Mehmedali</creator><creator>Avdiu, Muharrem</creator><creator>Ismaili-Jaha, Vlora</creator><creator>Grajqevci, Violeta</creator><creator>Petrela, Ela</creator><general>Academy of Medical Sciences of Bosnia and Herzegovina</general><general>AVICENA, d.o.o., Sarajevo</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BYOGL</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20141001</creationdate><title>The usefulness of clinical and laboratory parameters for predicting severity of dehydration in children with acute gastroenteritis</title><author>Hoxha, Teuta Faik ; Azemi, Mehmedali ; Avdiu, Muharrem ; Ismaili-Jaha, Vlora ; Grajqevci, Violeta ; Petrela, Ela</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3577-84d581b0caa68f58b8df6f3f27f6bc966fdcdb4d8a5d76112b4a29b9c628c55c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Acute Disease</topic><topic>Blood Gas Analysis</topic><topic>Child, Preschool</topic><topic>Creatinine - blood</topic><topic>Dehydration - diagnosis</topic><topic>Female</topic><topic>Gastroenteritis - complications</topic><topic>Humans</topic><topic>Infant</topic><topic>Male</topic><topic>Monitoring, Physiologic - methods</topic><topic>Original</topic><topic>Predictive Value of Tests</topic><topic>Severity of Illness Index</topic><topic>Urea - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hoxha, Teuta Faik</creatorcontrib><creatorcontrib>Azemi, Mehmedali</creatorcontrib><creatorcontrib>Avdiu, Muharrem</creatorcontrib><creatorcontrib>Ismaili-Jaha, Vlora</creatorcontrib><creatorcontrib>Grajqevci, Violeta</creatorcontrib><creatorcontrib>Petrela, Ela</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>East Europe, Central Europe Database</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Medicinski arhiv</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hoxha, Teuta Faik</au><au>Azemi, Mehmedali</au><au>Avdiu, Muharrem</au><au>Ismaili-Jaha, Vlora</au><au>Grajqevci, Violeta</au><au>Petrela, Ela</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The usefulness of clinical and laboratory parameters for predicting severity of dehydration in children with acute gastroenteritis</atitle><jtitle>Medicinski arhiv</jtitle><addtitle>Med Arch</addtitle><date>2014-10-01</date><risdate>2014</risdate><volume>68</volume><issue>5</issue><spage>304</spage><epage>307</epage><pages>304-307</pages><issn>0350-199X</issn><eissn>1986-5961</eissn><abstract>An accurate assessment of the degree of dehydration in infants and children is important for proper decision-making and treatment. This emphasizes the need for laboratory tests to improve the accuracy of clinical assessment of dehydration. The aim of this study was to assess the relationship between clinical and laboratory parameters in the assessment of dehydration.
We evaluated prospectively 200 children aged 1 month to 5 years who presented with diarrhea, vomiting or both. Dehydration assessment was done following a known clinical scheme.
We enrolled in the study 200 children (57.5% were male). The mean age was 15.62±9.03 months, with more than half those studied being under 24 months old. Overall, 46.5% (93) had mild dehydration, 34% (68) had moderate dehydration, 5.5% (11) had severe dehydration whereas, 14% (28) had no dehydration. Patients historical clinical variables in all dehydration groups did not differ significantly regarding age, sex, fever, frequency of vomiting, duration of diarrhea and vomiting, while there was a trend toward severe dehydration in children with more frequent diarrhea (p=0.004). Serum urea and creatinine cannot discriminate between mild and moderate dehydration but they showed a good specificity for severe dehydration of 99% and 100% respectively. Serum bicarbonates and base excess decreased significantly with a degree of dehydration and can discriminate between all dehydration groups (P<0.001).
Blood gases were useful to diagnose the degree of dehydration status among children presenting with acute gastroenteritis. Serum urea and creatinine were the most specific tests for severe dehydration diagnosis. Historical clinical patterns apart from frequency of diarrhea did not correlate with dehydration status. Further studies are needed to validate our results.</abstract><cop>Bosnia and Herzegovina</cop><pub>Academy of Medical Sciences of Bosnia and Herzegovina</pub><pmid>25568559</pmid><doi>10.5455/medarh.2014.68.304-307</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Medicinski arhiv, 2014-10, Vol.68 (5), p.304-307 |
| issn | 0350-199X 1986-5961 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; PubMed Central Open Access |
| subjects | Acute Disease Blood Gas Analysis Child, Preschool Creatinine - blood Dehydration - diagnosis Female Gastroenteritis - complications Humans Infant Male Monitoring, Physiologic - methods Original Predictive Value of Tests Severity of Illness Index Urea - blood |
| title | The usefulness of clinical and laboratory parameters for predicting severity of dehydration in children with acute gastroenteritis |
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