Nrf2 Knockout Attenuates the Anti-Inflammatory Effects of Phenethyl Isothiocyanate and Curcumin

The role of phytochemicals in preventive and therapeutic medicine is a major area of scientific research. Several studies have illustrated the mechanistic roles of phytochemicals in Nrf2 transcriptional activation. The present study aims to examine the importance of the transcription factor Nrf2 by...

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Veröffentlicht in:	Chemical research in toxicology 2014-12, Vol.27 (12), p.2036-2043
Hauptverfasser:	Boyanapalli, Sarandeep S. S, Paredes-Gonzalez, Ximena, Fuentes, Francisco, Zhang, Chengyue, Guo, Yue, Pung, Doug, Saw, Constance Lay Lay, Kong, Ah-Ng Tony
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents - pharmacology Base Sequence Curcumin - pharmacology DNA Primers Gene Expression Regulation - drug effects Interleukin-6 - metabolism Isothiocyanates - pharmacology Macrophages - drug effects Macrophages - metabolism Mice Mice, Inbred C57BL Mice, Knockout NF-E2-Related Factor 2 - genetics NF-E2-Related Factor 2 - physiology Nitrites - antagonists & inhibitors Nitrites - metabolism Tumor Necrosis Factor-alpha - metabolism
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