Aflatoxin B1 modulates the expression of phenotypic markers and cytokines by splenic lymphocytes of male F344 rats

ABSTRACT Aflatoxin B1 (AFB1) is immunotoxic to animals and a suspected immunosuppressant in humans. In this study, we investigated the effects of AFB1 on splenic lymphocyte phenotypes and the inflammatory cytokine expression in male F344 rats. Exposure of animals to AFB1 [5–75 µg kg–1 body weight (B...

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Veröffentlicht in:	Journal of applied toxicology 2014-03, Vol.34 (3), p.241-249
Hauptverfasser:	Qian, Guoqing, Tang, Lili, Guo, Xia, Wang, Franklin, Massey, Michael E., Su, Jianjia, Guo, Tai L., Williams, Jonathan H., Phillips, Timothy D., Wang, Jia-Sheng
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral aflatoxin B1 Aflatoxin B1 - toxicity Animals B-Lymphocytes - drug effects B-Lymphocytes - immunology cytokine Cytokines Cytokines - biosynthesis Dose-Response Relationship, Drug Environmental Pollutants - toxicity Flow Cytometry Immune system Killer Cells, Natural - drug effects Killer Cells, Natural - immunology lymphocyte Lymphocytes Lymphocytes - drug effects Lymphocytes - immunology Male Phenotype Rats Rats, Inbred F344 Rodents spleen Spleen - drug effects Spleen - immunology surface marker expression T-Lymphocyte Subsets - drug effects T-Lymphocyte Subsets - immunology
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