Control of cell migration through mRNA localization and local translation
Cell migration plays an important role in many normal and pathological functions such as development, wound healing, immune defense, and tumor metastasis. Polarized migrating cells exhibit asymmetric distribution of many cytoskeletal proteins, which is believed to be critical for establishing and ma...
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| Veröffentlicht in: | Wiley interdisciplinary reviews. RNA 2015-01, Vol.6 (1), p.1-15 |
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| creator | Liao, Guoning Mingle, Lisa Van De Water, Livingston Liu, Gang |
| description | Cell migration plays an important role in many normal and pathological functions such as development, wound healing, immune defense, and tumor metastasis. Polarized migrating cells exhibit asymmetric distribution of many cytoskeletal proteins, which is believed to be critical for establishing and maintaining cell polarity and directional cell migration. To target these proteins to the site of function, cells use a variety of mechanisms such as protein transport and messenger RNA (mRNA) localization‐mediated local protein synthesis. In contrast to the former which is intensively investigated and relatively well understood, the latter has been understudied and relatively poorly understood. However, recent advances in the study of mRNA localization and local translation have demonstrated that mRNA localization and local translation are specific and effective ways for protein localization and are crucial for embryo development, neuronal function, and many other cellular processes. There are excellent reviews on mRNA localization, transport, and translation during development and other cellular processes. This review will focus on mRNA localization‐mediated local protein biogenesis and its impact on somatic cell migration. WIREs RNA 2015, 6:1–15. doi: 10.1002/wrna.1265
This article is categorized under:
RNA Interactions with Proteins and Other Molecules > Protein–RNA Interactions: Functional Implications
Translation > Translation Regulation
RNA Export and Localization > RNA Localization |
| doi_str_mv | 10.1002/wrna.1265 |
| format | Article |
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This article is categorized under:
RNA Interactions with Proteins and Other Molecules > Protein–RNA Interactions: Functional Implications
Translation > Translation Regulation
RNA Export and Localization > RNA Localization</description><identifier>ISSN: 1757-7004</identifier><identifier>EISSN: 1757-7012</identifier><identifier>DOI: 10.1002/wrna.1265</identifier><identifier>PMID: 25264217</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>Animals ; Biological Transport ; Cell adhesion & migration ; Cell migration ; Cell Movement ; Cell Polarity ; Cytoskeleton ; Gene Expression ; Humans ; Immune system ; Localization ; Metastases ; mRNA ; Polarity ; Protein Biosynthesis ; Protein transport ; Proteins ; RNA transport ; RNA, Messenger - metabolism ; Transcription ; Translation ; Wound healing</subject><ispartof>Wiley interdisciplinary reviews. RNA, 2015-01, Vol.6 (1), p.1-15</ispartof><rights>2014 John Wiley & Sons, Ltd.</rights><rights>2015 John Wiley & Sons, Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4815-67d0fee141942345c2ec0eb481c3280ee0462478586a0cd5aebef2e24f6062793</citedby><cites>FETCH-LOGICAL-c4815-67d0fee141942345c2ec0eb481c3280ee0462478586a0cd5aebef2e24f6062793</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fwrna.1265$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fwrna.1265$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,780,784,885,1416,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25264217$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liao, Guoning</creatorcontrib><creatorcontrib>Mingle, Lisa</creatorcontrib><creatorcontrib>Van De Water, Livingston</creatorcontrib><creatorcontrib>Liu, Gang</creatorcontrib><title>Control of cell migration through mRNA localization and local translation</title><title>Wiley interdisciplinary reviews. RNA</title><addtitle>WIREs RNA</addtitle><description>Cell migration plays an important role in many normal and pathological functions such as development, wound healing, immune defense, and tumor metastasis. Polarized migrating cells exhibit asymmetric distribution of many cytoskeletal proteins, which is believed to be critical for establishing and maintaining cell polarity and directional cell migration. To target these proteins to the site of function, cells use a variety of mechanisms such as protein transport and messenger RNA (mRNA) localization‐mediated local protein synthesis. In contrast to the former which is intensively investigated and relatively well understood, the latter has been understudied and relatively poorly understood. However, recent advances in the study of mRNA localization and local translation have demonstrated that mRNA localization and local translation are specific and effective ways for protein localization and are crucial for embryo development, neuronal function, and many other cellular processes. There are excellent reviews on mRNA localization, transport, and translation during development and other cellular processes. This review will focus on mRNA localization‐mediated local protein biogenesis and its impact on somatic cell migration. WIREs RNA 2015, 6:1–15. doi: 10.1002/wrna.1265
This article is categorized under:
RNA Interactions with Proteins and Other Molecules > Protein–RNA Interactions: Functional Implications
Translation > Translation Regulation
RNA Export and Localization > RNA Localization</description><subject>Animals</subject><subject>Biological Transport</subject><subject>Cell adhesion & migration</subject><subject>Cell migration</subject><subject>Cell Movement</subject><subject>Cell Polarity</subject><subject>Cytoskeleton</subject><subject>Gene Expression</subject><subject>Humans</subject><subject>Immune system</subject><subject>Localization</subject><subject>Metastases</subject><subject>mRNA</subject><subject>Polarity</subject><subject>Protein Biosynthesis</subject><subject>Protein transport</subject><subject>Proteins</subject><subject>RNA transport</subject><subject>RNA, Messenger - metabolism</subject><subject>Transcription</subject><subject>Translation</subject><subject>Wound healing</subject><issn>1757-7004</issn><issn>1757-7012</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kU1v1DAQhi0EolXpgT-AInGBQ1p74o_kglStoFSUIiFQe7O83smuixMXO-kHvx6HLCtAwhdb8z7zasYvIc8ZPWKUwvFd7M0RAykekX2mhCoVZfB496Z8jxymdE3z4RQUY0_JHgiQHJjaJ2eL0A8x-CK0hUXvi86toxlc6IthE8O43hTd54uTwgdrvPsxK6ZfzYViiKZP_lf1GXnSGp_wcHsfkK_v3n5ZvC_PP52eLU7OS8trJkqpVrRFZJw1HCouLKCluMyaraCmiJRL4KoWtTTUroTBJbaAwFtJJaimOiBvZt-bcdnhymKe33h9E11n4oMOxum_ld5t9Drcag6yrprJ4NXWIIbvI6ZBdy5Nu5sew5g0k5USUgkqMvryH_Q6jPm_faaaBgTjlaoz9XqmbAwpRWx3wzCqp4z0lJGeMsrsiz-n35G_E8nA8QzcOY8P_3fSlzmWrWU5d7g04P2uw8RvWqq8ir68ONXVFXzgHxdMX1U_AUi7qnw</recordid><startdate>201501</startdate><enddate>201501</enddate><creator>Liao, Guoning</creator><creator>Mingle, Lisa</creator><creator>Van De Water, Livingston</creator><creator>Liu, Gang</creator><general>John Wiley & Sons, Inc</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201501</creationdate><title>Control of cell migration through mRNA localization and local translation</title><author>Liao, Guoning ; Mingle, Lisa ; Van De Water, Livingston ; Liu, Gang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4815-67d0fee141942345c2ec0eb481c3280ee0462478586a0cd5aebef2e24f6062793</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Animals</topic><topic>Biological Transport</topic><topic>Cell adhesion & migration</topic><topic>Cell migration</topic><topic>Cell Movement</topic><topic>Cell Polarity</topic><topic>Cytoskeleton</topic><topic>Gene Expression</topic><topic>Humans</topic><topic>Immune system</topic><topic>Localization</topic><topic>Metastases</topic><topic>mRNA</topic><topic>Polarity</topic><topic>Protein Biosynthesis</topic><topic>Protein transport</topic><topic>Proteins</topic><topic>RNA transport</topic><topic>RNA, Messenger - metabolism</topic><topic>Transcription</topic><topic>Translation</topic><topic>Wound healing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liao, Guoning</creatorcontrib><creatorcontrib>Mingle, Lisa</creatorcontrib><creatorcontrib>Van De Water, Livingston</creatorcontrib><creatorcontrib>Liu, Gang</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Wiley interdisciplinary reviews. RNA</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liao, Guoning</au><au>Mingle, Lisa</au><au>Van De Water, Livingston</au><au>Liu, Gang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Control of cell migration through mRNA localization and local translation</atitle><jtitle>Wiley interdisciplinary reviews. RNA</jtitle><addtitle>WIREs RNA</addtitle><date>2015-01</date><risdate>2015</risdate><volume>6</volume><issue>1</issue><spage>1</spage><epage>15</epage><pages>1-15</pages><issn>1757-7004</issn><eissn>1757-7012</eissn><abstract>Cell migration plays an important role in many normal and pathological functions such as development, wound healing, immune defense, and tumor metastasis. Polarized migrating cells exhibit asymmetric distribution of many cytoskeletal proteins, which is believed to be critical for establishing and maintaining cell polarity and directional cell migration. To target these proteins to the site of function, cells use a variety of mechanisms such as protein transport and messenger RNA (mRNA) localization‐mediated local protein synthesis. In contrast to the former which is intensively investigated and relatively well understood, the latter has been understudied and relatively poorly understood. However, recent advances in the study of mRNA localization and local translation have demonstrated that mRNA localization and local translation are specific and effective ways for protein localization and are crucial for embryo development, neuronal function, and many other cellular processes. There are excellent reviews on mRNA localization, transport, and translation during development and other cellular processes. This review will focus on mRNA localization‐mediated local protein biogenesis and its impact on somatic cell migration. WIREs RNA 2015, 6:1–15. doi: 10.1002/wrna.1265
This article is categorized under:
RNA Interactions with Proteins and Other Molecules > Protein–RNA Interactions: Functional Implications
Translation > Translation Regulation
RNA Export and Localization > RNA Localization</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><pmid>25264217</pmid><doi>10.1002/wrna.1265</doi><tpages>15</tpages><oa>free_for_read</oa></addata></record> |
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| language | eng |
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| source | MEDLINE; Wiley Online Library All Journals |
| subjects | Animals Biological Transport Cell adhesion & migration Cell migration Cell Movement Cell Polarity Cytoskeleton Gene Expression Humans Immune system Localization Metastases mRNA Polarity Protein Biosynthesis Protein transport Proteins RNA transport RNA, Messenger - metabolism Transcription Translation Wound healing |
| title | Control of cell migration through mRNA localization and local translation |
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