Cholesterol and breast cancer pathophysiology

Cholesterol and breast cancer pathophysiology

Highlights • Elevated cholesterol is associated with breast cancer risk. • Cholesterol promotes breast tumor growth and metastasis in murine models. • A cholesterol metabolite acts as an estrogen receptor agonist to promote tumor growth. • Novel strategies to target cholesterol/oxysterol metabolism....

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Veröffentlicht in:Trends in endocrinology and metabolism 2014-12, Vol.25 (12), p.649-655
Hauptverfasser: Nelson, Erik R, Chang, Ching-yi, McDonnell, Donald P
Format: Artikel
Sprache:eng
Schlagworte:
Breast Neoplasms - metabolism
Cholesterol - metabolism
Endocrinology & Metabolism
Female
Humans
Hydroxycholesterols - metabolism
Liver X Receptors
Orphan Nuclear Receptors - metabolism
Receptors, Estrogen - metabolism
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container_end_page 655
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container_title Trends in endocrinology and metabolism
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creator Nelson, Erik R
Chang, Ching-yi
McDonnell, Donald P
description Highlights • Elevated cholesterol is associated with breast cancer risk. • Cholesterol promotes breast tumor growth and metastasis in murine models. • A cholesterol metabolite acts as an estrogen receptor agonist to promote tumor growth. • Novel strategies to target cholesterol/oxysterol metabolism.
doi_str_mv 10.1016/j.tem.2014.10.001
format Article
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source MEDLINE; ScienceDirect Journals (5 years ago - present)
subjects Breast Neoplasms - metabolism
Cholesterol - metabolism
Endocrinology & Metabolism
Female
Humans
Hydroxycholesterols - metabolism
Liver X Receptors
Orphan Nuclear Receptors - metabolism
Receptors, Estrogen - metabolism
title Cholesterol and breast cancer pathophysiology
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