Cholesterol and breast cancer pathophysiology

Cholesterol and breast cancer pathophysiology

Highlights • Elevated cholesterol is associated with breast cancer risk. • Cholesterol promotes breast tumor growth and metastasis in murine models. • A cholesterol metabolite acts as an estrogen receptor agonist to promote tumor growth. • Novel strategies to target cholesterol/oxysterol metabolism....

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Veröffentlicht in:Trends in endocrinology and metabolism 2014-12, Vol.25 (12), p.649-655
Hauptverfasser: Nelson, Erik R, Chang, Ching-yi, McDonnell, Donald P
Format: Artikel
Sprache:eng
Schlagworte:
Breast Neoplasms - metabolism
Cholesterol - metabolism
Endocrinology & Metabolism
Female
Humans
Hydroxycholesterols - metabolism
Liver X Receptors
Orphan Nuclear Receptors - metabolism
Receptors, Estrogen - metabolism
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Zusammenfassung:Highlights • Elevated cholesterol is associated with breast cancer risk. • Cholesterol promotes breast tumor growth and metastasis in murine models. • A cholesterol metabolite acts as an estrogen receptor agonist to promote tumor growth. • Novel strategies to target cholesterol/oxysterol metabolism.
ISSN:1043-2760
1879-3061
1879-3061
DOI:10.1016/j.tem.2014.10.001