Specific contributions of N-methyl- d -aspartate receptors in the dorsal striatum to cognitive flexibility
Highlights • Reduction of NR1 expression in the dorsal striatum impairs cognitive flexibility. • Partial loss of NR1 expression in the dorsal striatum does not impair motor coordination. • Targeting of NR1 expression in direct pathway causes impaired cognitive flexibility.
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| Veröffentlicht in: | Neuroscience 2015-01, Vol.284, p.934-942 |
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| container_title | Neuroscience |
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| creator | Darvas, M Palmiter, R.D |
| description | Highlights • Reduction of NR1 expression in the dorsal striatum impairs cognitive flexibility. • Partial loss of NR1 expression in the dorsal striatum does not impair motor coordination. • Targeting of NR1 expression in direct pathway causes impaired cognitive flexibility. |
| doi_str_mv | 10.1016/j.neuroscience.2014.11.011 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 0306-4522 |
| ispartof | Neuroscience, 2015-01, Vol.284, p.934-942 |
| issn | 0306-4522 1873-7544 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4267923 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Animals Cognition - physiology Corpus Striatum - metabolism direct pathway Dynorphins - metabolism Enkephalins - genetics Enkephalins - metabolism executive function Executive Function - physiology Exploratory Behavior - physiology HEK293 Cells Humans knockout learning Maze Learning - physiology medium spiny neuron Mice, Inbred C57BL Mice, Knockout Mice, Transgenic Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Neurology Neuronal Plasticity - physiology plasticity Protein Precursors - genetics Protein Precursors - metabolism Psychomotor Performance - physiology Receptors, N-Methyl-D-Aspartate - genetics Receptors, N-Methyl-D-Aspartate - metabolism Reversal Learning - physiology |
| title | Specific contributions of N-methyl- d -aspartate receptors in the dorsal striatum to cognitive flexibility |
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