CCN2 as a Novel Molecule Supporting Energy Metabolism of Chondrocytes

ABSTRACT CCN2/connective tissue growth factor (CTGF) is a unique molecule that promotes both chondrocytic differentiation and proliferation through its matricellular interaction with a number of extracellular biomolecules. This apparently contradictory functional property of CCN2 suggests its certai...

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Veröffentlicht in:	Journal of cellular biochemistry 2014-05, Vol.115 (5), p.854-865
Hauptverfasser:	Maeda-Uematsu, Aya, Kubota, Satoshi, Kawaki, Harumi, Kawata, Kazumi, Miyake, Yoshiaki, Hattori, Takako, Nishida, Takashi, Moritani, Norifumi, Lyons, Karen M., Iida, Seiji, Takigawa, Masaharu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals ATP Biomolecules CARTILAGE CCN2 Cell Differentiation - genetics Cell Line CHONDROCYTES Chondrocytes - metabolism Chondrogenesis Connective tissue growth factor Connective Tissue Growth Factor - genetics Connective tissues Cost analysis CTGF CTP Cytidine triphosphate Deletion Differentiation Energy Metabolism Gene expression Gene Expression Regulation - genetics Genes Growth factors Growth Plate - metabolism METABOLISM Metabolites Metabolomics Mice Phosphopyruvate hydratase Reduction Ribosomal Proteins - biosynthesis Skeletogenesis Transcriptomes
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