Multifunctional Effects of Mangosteen Pericarp on Cognition in C57BL/6J and Triple Transgenic Alzheimer’s Mice
Mangosteen- (Garcinia mangostana-) based nutraceutical compounds have long been reported to possess multiple health-promoting properties. The current study investigated whether mangosteen pericarp (MP) could attenuate cognitive dysfunction. First, we found that treatment with MP significantly reduce...
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| Veröffentlicht in: | Evidence-based complementary and alternative medicine 2014-01, Vol.2014 (2014), p.1-18 |
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| creator | Hsieh-Li, Hsiu Mei Hsieh, Rong-Hong Chen, Wei-Lin |
| description | Mangosteen- (Garcinia mangostana-) based nutraceutical compounds have long been reported to possess multiple health-promoting properties. The current study investigated whether mangosteen pericarp (MP) could attenuate cognitive dysfunction. First, we found that treatment with MP significantly reduced the cell death and increased the brain-derived neurotrophic factor (BDNF) level in an organotypic hippocampal slice culture (OHSC). We then investigated the effects of age and MP diet on the cognitive function of male C57BL/6J (B6) mice. After 8-month dietary supplementation, the MP diet (5000 ppm) significantly attenuated the cognitive impairment associated with anti-inflammation, increasing BDNF level and decreasing p-tau (phospho-tau S202) in older B6 mice. We further applied MP dietary supplementation to triple transgenic Alzheimer’s disease (3×Tg-AD) mice from 5 to 13 months old. The MP diet exerted neuroprotective, antioxidative, and anti-inflammatory effects and reduced the Aβ deposition and p-tau (S202/S262) levels in the hippocampus of 3×Tg-AD mice, which might further attenuate the deficit in spatial memory retrieval. Thus, these results revealed that the multifunctional properties of MP might offer a promising supplementary diet to attenuate cognitive dysfunction in AD. |
| doi_str_mv | 10.1155/2014/813672 |
| format | Article |
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The current study investigated whether mangosteen pericarp (MP) could attenuate cognitive dysfunction. First, we found that treatment with MP significantly reduced the cell death and increased the brain-derived neurotrophic factor (BDNF) level in an organotypic hippocampal slice culture (OHSC). We then investigated the effects of age and MP diet on the cognitive function of male C57BL/6J (B6) mice. After 8-month dietary supplementation, the MP diet (5000 ppm) significantly attenuated the cognitive impairment associated with anti-inflammation, increasing BDNF level and decreasing p-tau (phospho-tau S202) in older B6 mice. We further applied MP dietary supplementation to triple transgenic Alzheimer’s disease (3×Tg-AD) mice from 5 to 13 months old. The MP diet exerted neuroprotective, antioxidative, and anti-inflammatory effects and reduced the Aβ deposition and p-tau (S202/S262) levels in the hippocampus of 3×Tg-AD mice, which might further attenuate the deficit in spatial memory retrieval. Thus, these results revealed that the multifunctional properties of MP might offer a promising supplementary diet to attenuate cognitive dysfunction in AD.</description><identifier>ISSN: 1741-427X</identifier><identifier>EISSN: 1741-4288</identifier><identifier>DOI: 10.1155/2014/813672</identifier><identifier>PMID: 25525451</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Age factors ; Alzheimer's disease ; Apoptosis ; Brain research ; Brain slice preparation ; Brain-derived neurotrophic factor ; Cell culture ; Cell death ; Cognitive ability ; Diet ; Dietary supplements ; Garcinia mangostana ; Health promotion ; Hippocampus ; Inflammation ; Laboratory animals ; Memory ; Mice ; Neuroprotection ; Neurosciences ; Pericarp ; Polyphenols ; Proteins ; Rodents ; Spatial memory ; Tau protein ; Transgenic mice</subject><ispartof>Evidence-based complementary and alternative medicine, 2014-01, Vol.2014 (2014), p.1-18</ispartof><rights>Copyright © 2014 Hei-Jen Huang et al.</rights><rights>Copyright © 2014 Hei-Jen Huang et al.; This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2014 Hei-Jen Huang et al. 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c500t-ba685a75f6e8f025fcf25f81596d5447146df1f36467504e541cf1975a26d5233</citedby><cites>FETCH-LOGICAL-c500t-ba685a75f6e8f025fcf25f81596d5447146df1f36467504e541cf1975a26d5233</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4267462/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4267462/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25525451$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Oh, Ki-Wan</contributor><creatorcontrib>Hsieh-Li, Hsiu Mei</creatorcontrib><creatorcontrib>Hsieh, Rong-Hong</creatorcontrib><creatorcontrib>Chen, Wei-Lin</creatorcontrib><title>Multifunctional Effects of Mangosteen Pericarp on Cognition in C57BL/6J and Triple Transgenic Alzheimer’s Mice</title><title>Evidence-based complementary and alternative medicine</title><addtitle>Evid Based Complement Alternat Med</addtitle><description>Mangosteen- (Garcinia mangostana-) based nutraceutical compounds have long been reported to possess multiple health-promoting properties. The current study investigated whether mangosteen pericarp (MP) could attenuate cognitive dysfunction. First, we found that treatment with MP significantly reduced the cell death and increased the brain-derived neurotrophic factor (BDNF) level in an organotypic hippocampal slice culture (OHSC). We then investigated the effects of age and MP diet on the cognitive function of male C57BL/6J (B6) mice. After 8-month dietary supplementation, the MP diet (5000 ppm) significantly attenuated the cognitive impairment associated with anti-inflammation, increasing BDNF level and decreasing p-tau (phospho-tau S202) in older B6 mice. We further applied MP dietary supplementation to triple transgenic Alzheimer’s disease (3×Tg-AD) mice from 5 to 13 months old. The MP diet exerted neuroprotective, antioxidative, and anti-inflammatory effects and reduced the Aβ deposition and p-tau (S202/S262) levels in the hippocampus of 3×Tg-AD mice, which might further attenuate the deficit in spatial memory retrieval. Thus, these results revealed that the multifunctional properties of MP might offer a promising supplementary diet to attenuate cognitive dysfunction in AD.</description><subject>Age factors</subject><subject>Alzheimer's disease</subject><subject>Apoptosis</subject><subject>Brain research</subject><subject>Brain slice preparation</subject><subject>Brain-derived neurotrophic factor</subject><subject>Cell culture</subject><subject>Cell death</subject><subject>Cognitive ability</subject><subject>Diet</subject><subject>Dietary supplements</subject><subject>Garcinia mangostana</subject><subject>Health promotion</subject><subject>Hippocampus</subject><subject>Inflammation</subject><subject>Laboratory animals</subject><subject>Memory</subject><subject>Mice</subject><subject>Neuroprotection</subject><subject>Neurosciences</subject><subject>Pericarp</subject><subject>Polyphenols</subject><subject>Proteins</subject><subject>Rodents</subject><subject>Spatial memory</subject><subject>Tau protein</subject><subject>Transgenic mice</subject><issn>1741-427X</issn><issn>1741-4288</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqN0c9rFDEUB_AgFltXT94l4EUq6yaZ_Ji5CHWprbKLHip4C2nmZTdlNpkmMxY9-W_47_mXNMvWpXrRS15CPjxe8kXoGSWvKRVixgjls5pWUrEH6IgqTqec1fXD_V59OUSPc74ihDVKqUfokAnBBBf0CPXLsRu8G4MdfAymw6fOgR0yjg4vTVjFPAAE_AmStyb1OAY8j6vgtxr7chDq7WImP2ATWnyRfN9BKSbkFQRv8Un3fQ1-A-nXj58ZL72FJ-jAmS7D07s6QZ_fnV7Mz6eLj2fv5yeLqRWEDNNLI2thlHASakeYcNaVpaaika3gXFEuW0ddJblUgnAQnFpHGyUMK4BV1QS92fXtx8sNtBbCkEyn--Q3Jn3T0Xj9503wa72KXzVnUnHJSoOXdw1SvB4hD3rjs4WuMwHimDVVZcKaKiL_TWXV8IYxvqUv_qJXcUzl47NmRLKa0KZEOUGvdsqmmHMCt5-bEr0NXW9D17vQi35-_6l7-zvlAo53YO1Da278_3WDQsCZe7gSlaqrW2_DvVY</recordid><startdate>20140101</startdate><enddate>20140101</enddate><creator>Hsieh-Li, Hsiu Mei</creator><creator>Hsieh, Rong-Hong</creator><creator>Chen, Wei-Lin</creator><general>Hindawi Publishing Corporation</general><general>Hindawi Limited</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7T5</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88G</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M2M</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>5PM</scope></search><sort><creationdate>20140101</creationdate><title>Multifunctional Effects of Mangosteen Pericarp on Cognition in C57BL/6J and Triple Transgenic Alzheimer’s Mice</title><author>Hsieh-Li, Hsiu Mei ; Hsieh, Rong-Hong ; Chen, Wei-Lin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c500t-ba685a75f6e8f025fcf25f81596d5447146df1f36467504e541cf1975a26d5233</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Age factors</topic><topic>Alzheimer's disease</topic><topic>Apoptosis</topic><topic>Brain research</topic><topic>Brain slice preparation</topic><topic>Brain-derived neurotrophic factor</topic><topic>Cell culture</topic><topic>Cell death</topic><topic>Cognitive ability</topic><topic>Diet</topic><topic>Dietary supplements</topic><topic>Garcinia mangostana</topic><topic>Health promotion</topic><topic>Hippocampus</topic><topic>Inflammation</topic><topic>Laboratory animals</topic><topic>Memory</topic><topic>Mice</topic><topic>Neuroprotection</topic><topic>Neurosciences</topic><topic>Pericarp</topic><topic>Polyphenols</topic><topic>Proteins</topic><topic>Rodents</topic><topic>Spatial memory</topic><topic>Tau protein</topic><topic>Transgenic mice</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hsieh-Li, Hsiu Mei</creatorcontrib><creatorcontrib>Hsieh, Rong-Hong</creatorcontrib><creatorcontrib>Chen, Wei-Lin</creatorcontrib><collection>الدوريات العلمية والإحصائية - 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The current study investigated whether mangosteen pericarp (MP) could attenuate cognitive dysfunction. First, we found that treatment with MP significantly reduced the cell death and increased the brain-derived neurotrophic factor (BDNF) level in an organotypic hippocampal slice culture (OHSC). We then investigated the effects of age and MP diet on the cognitive function of male C57BL/6J (B6) mice. After 8-month dietary supplementation, the MP diet (5000 ppm) significantly attenuated the cognitive impairment associated with anti-inflammation, increasing BDNF level and decreasing p-tau (phospho-tau S202) in older B6 mice. We further applied MP dietary supplementation to triple transgenic Alzheimer’s disease (3×Tg-AD) mice from 5 to 13 months old. The MP diet exerted neuroprotective, antioxidative, and anti-inflammatory effects and reduced the Aβ deposition and p-tau (S202/S262) levels in the hippocampus of 3×Tg-AD mice, which might further attenuate the deficit in spatial memory retrieval. Thus, these results revealed that the multifunctional properties of MP might offer a promising supplementary diet to attenuate cognitive dysfunction in AD.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>25525451</pmid><doi>10.1155/2014/813672</doi><tpages>18</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Age factors Alzheimer's disease Apoptosis Brain research Brain slice preparation Brain-derived neurotrophic factor Cell culture Cell death Cognitive ability Diet Dietary supplements Garcinia mangostana Health promotion Hippocampus Inflammation Laboratory animals Memory Mice Neuroprotection Neurosciences Pericarp Polyphenols Proteins Rodents Spatial memory Tau protein Transgenic mice |
| title | Multifunctional Effects of Mangosteen Pericarp on Cognition in C57BL/6J and Triple Transgenic Alzheimer’s Mice |
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