MACROD2 overexpression mediates estrogen independent growth and tamoxifen resistance in breast cancers

Tamoxifen is effective for treating estrogen receptor-alpha (ER) positive breast cancers. However, few molecular mediators of tamoxifen resistance have been elucidated. Here we describe a previously unidentified gene, MACROD2 that confers tamoxifen resistance and estrogen independent growth. We foun...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2014-12, Vol.111 (49), p.17606-17611
Hauptverfasser:	Mohseni, Morassa, Cidado, Justin, Croessmann, Sarah, Cravero, Karen, Cimino-Mathews, Ashley, Wong, Hong Yuen, Scharpf, Rob, Zabransky, Daniel J, Abukhdeir, Abde M, Garay, Joseph P, Wang, Grace M, Beaver, Julia A, Cochran, Rory L, Blair, Brian G, Rosen, D Marc, Erlanger, Bracha, Argani, Pedram, Hurley, Paula J, Lauring, Josh, Park, Ben Ho
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence Biological Sciences Breast cancer breast neoplasms Breast Neoplasms - metabolism Cell Line, Tumor Cell Proliferation DNA Repair Enzymes - metabolism Drug resistance Drug Resistance, Neoplasm Epigenesis, Genetic Estrogens Estrogens - metabolism Female Gene Deletion Gene Dosage Gene expression gene overexpression genes human growth Humans Hydrolases - metabolism Metastasis Molecular Sequence Data Neoplasm Transplantation Phenotype Prescription drugs Prognosis Receptors, Estrogen - metabolism RNA Interference RNA, Small Interfering - metabolism tamoxifen Tamoxifen - pharmacology Transgenes Treatment Outcome
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