HIV-1–induced AIDS in monkeys

Primate lentiviruses exhibit narrow host tropism, reducing the occurrence of zoonoses but also impairing the development of optimal animal models of AIDS. To delineate the factors limiting cross-species HIV-1 transmission, we passaged a modified HIV-1 in pigtailed macaques that were transiently depl...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2014-06, Vol.344 (6190), p.1401-1405
Hauptverfasser:	Hatziioannou, Theodora, Del Prete, Gregory Q., Keele, Brandon F., Estes, Jacob D., McNatt, Matthew W., Bitzegeio, Julia, Raymond, Alice, Rodriguez, Anthony, Schmidt, Fabian, Trubey, C. Mac, Smedley, Jeremy, Piatak, Michael, KewalRamani, Vineet N., Lifson, Jeffrey D., Bieniasz, Paul D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired immune deficiency syndrome Acquired immunodeficiency syndrome Acquired Immunodeficiency Syndrome - immunology Acquired Immunodeficiency Syndrome - transmission Acquired Immunodeficiency Syndrome - virology AIDS Amino Acid Sequence Amino acids Animals Blood Blood plasma CD4-Positive T-Lymphocytes - immunology CD8 Antigens - immunology Depletion Disease Models, Animal Genes HIV HIV 1 HIV-1 - genetics HIV-1 - physiology Host-Pathogen Interactions - immunology Human Human immunodeficiency virus Human immunodeficiency virus 1 Human Immunodeficiency Virus Proteins - chemistry Human Immunodeficiency Virus Proteins - genetics Human Immunodeficiency Virus Proteins - metabolism Immunology Infections Lymphocyte Depletion Macaca Macaca nemestrina - immunology Macaca nemestrina - virology Molecular Sequence Data Monkeys Monkeys & apes Mutation Mutations Pigtails Protein Structure, Tertiary Proteins T lymphocytes Viral Regulatory and Accessory Proteins - chemistry Viral Regulatory and Accessory Proteins - genetics Viral Regulatory and Accessory Proteins - metabolism Viremia Virology Virus Replication
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