HIV-1–induced AIDS in monkeys
Primate lentiviruses exhibit narrow host tropism, reducing the occurrence of zoonoses but also impairing the development of optimal animal models of AIDS. To delineate the factors limiting cross-species HIV-1 transmission, we passaged a modified HIV-1 in pigtailed macaques that were transiently depl...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 2014-06, Vol.344 (6190), p.1401-1405 |
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| creator | Hatziioannou, Theodora Del Prete, Gregory Q. Keele, Brandon F. Estes, Jacob D. McNatt, Matthew W. Bitzegeio, Julia Raymond, Alice Rodriguez, Anthony Schmidt, Fabian Trubey, C. Mac Smedley, Jeremy Piatak, Michael KewalRamani, Vineet N. Lifson, Jeffrey D. Bieniasz, Paul D. |
| description | Primate lentiviruses exhibit narrow host tropism, reducing the occurrence of zoonoses but also impairing the development of optimal animal models of AIDS. To delineate the factors limiting cross-species HIV-1 transmission, we passaged a modified HIV-1 in pigtailed macaques that were transiently depleted of CD8+ cells during acute infection. During adaptation over four passages in macaques, HIV-1 acquired the ability to antagonize the macaque restriction factor tetherin, replicated at progressively higher levels, and ultimately caused marked CD4+ T cell depletion and AIDS-defining conditions. Transient treatment with an antibody to CD8 during acute HIV-1 infection caused rapid progression to AIDS, whereas untreated animals exhibited an elite controller phenotype. Thus, an adapted HIV-1 can cause AIDS in macaques, and stark differences in outcome can be determined by immunological perturbations during early infection. |
| doi_str_mv | 10.1126/science.1250761 |
| format | Article |
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Mac ; Smedley, Jeremy ; Piatak, Michael ; KewalRamani, Vineet N. ; Lifson, Jeffrey D. ; Bieniasz, Paul D.</creator><creatorcontrib>Hatziioannou, Theodora ; Del Prete, Gregory Q. ; Keele, Brandon F. ; Estes, Jacob D. ; McNatt, Matthew W. ; Bitzegeio, Julia ; Raymond, Alice ; Rodriguez, Anthony ; Schmidt, Fabian ; Trubey, C. Mac ; Smedley, Jeremy ; Piatak, Michael ; KewalRamani, Vineet N. ; Lifson, Jeffrey D. ; Bieniasz, Paul D.</creatorcontrib><description>Primate lentiviruses exhibit narrow host tropism, reducing the occurrence of zoonoses but also impairing the development of optimal animal models of AIDS. To delineate the factors limiting cross-species HIV-1 transmission, we passaged a modified HIV-1 in pigtailed macaques that were transiently depleted of CD8+ cells during acute infection. During adaptation over four passages in macaques, HIV-1 acquired the ability to antagonize the macaque restriction factor tetherin, replicated at progressively higher levels, and ultimately caused marked CD4+ T cell depletion and AIDS-defining conditions. Transient treatment with an antibody to CD8 during acute HIV-1 infection caused rapid progression to AIDS, whereas untreated animals exhibited an elite controller phenotype. Thus, an adapted HIV-1 can cause AIDS in macaques, and stark differences in outcome can be determined by immunological perturbations during early infection.</description><identifier>ISSN: 0036-8075</identifier><identifier>ISSN: 1095-9203</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.1250761</identifier><identifier>PMID: 24948736</identifier><identifier>CODEN: SCIEAS</identifier><language>eng</language><publisher>United States: American Association for the Advancement of Science</publisher><subject>Acquired immune deficiency syndrome ; Acquired immunodeficiency syndrome ; Acquired Immunodeficiency Syndrome - immunology ; Acquired Immunodeficiency Syndrome - transmission ; Acquired Immunodeficiency Syndrome - virology ; AIDS ; Amino Acid Sequence ; Amino acids ; Animals ; Blood ; Blood plasma ; CD4-Positive T-Lymphocytes - immunology ; CD8 Antigens - immunology ; Depletion ; Disease Models, Animal ; Genes ; HIV ; HIV 1 ; HIV-1 - genetics ; HIV-1 - physiology ; Host-Pathogen Interactions - immunology ; Human ; Human immunodeficiency virus ; Human immunodeficiency virus 1 ; Human Immunodeficiency Virus Proteins - chemistry ; Human Immunodeficiency Virus Proteins - genetics ; Human Immunodeficiency Virus Proteins - metabolism ; Immunology ; Infections ; Lymphocyte Depletion ; Macaca ; Macaca nemestrina - immunology ; Macaca nemestrina - virology ; Molecular Sequence Data ; Monkeys ; Monkeys & apes ; Mutation ; Mutations ; Pigtails ; Protein Structure, Tertiary ; Proteins ; T lymphocytes ; Viral Regulatory and Accessory Proteins - chemistry ; Viral Regulatory and Accessory Proteins - genetics ; Viral Regulatory and Accessory Proteins - metabolism ; Viremia ; Virology ; Virus Replication</subject><ispartof>Science (American Association for the Advancement of Science), 2014-06, Vol.344 (6190), p.1401-1405</ispartof><rights>Copyright © 2014 American Association for the Advancement of Science</rights><rights>Copyright © 2014, American Association for the Advancement of Science.</rights><rights>Copyright © 2014, American Association for the Advancement of Science</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c575t-2131ddb651ba96cbd51e52996f0fc60e147f63f3196836970e017da3954e29c03</citedby><cites>FETCH-LOGICAL-c575t-2131ddb651ba96cbd51e52996f0fc60e147f63f3196836970e017da3954e29c03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/24744710$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/24744710$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,780,784,803,885,2884,2885,27924,27925,58017,58250</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24948736$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hatziioannou, Theodora</creatorcontrib><creatorcontrib>Del Prete, Gregory Q.</creatorcontrib><creatorcontrib>Keele, Brandon F.</creatorcontrib><creatorcontrib>Estes, Jacob D.</creatorcontrib><creatorcontrib>McNatt, Matthew W.</creatorcontrib><creatorcontrib>Bitzegeio, Julia</creatorcontrib><creatorcontrib>Raymond, Alice</creatorcontrib><creatorcontrib>Rodriguez, Anthony</creatorcontrib><creatorcontrib>Schmidt, Fabian</creatorcontrib><creatorcontrib>Trubey, C. Mac</creatorcontrib><creatorcontrib>Smedley, Jeremy</creatorcontrib><creatorcontrib>Piatak, Michael</creatorcontrib><creatorcontrib>KewalRamani, Vineet N.</creatorcontrib><creatorcontrib>Lifson, Jeffrey D.</creatorcontrib><creatorcontrib>Bieniasz, Paul D.</creatorcontrib><title>HIV-1–induced AIDS in monkeys</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>Primate lentiviruses exhibit narrow host tropism, reducing the occurrence of zoonoses but also impairing the development of optimal animal models of AIDS. To delineate the factors limiting cross-species HIV-1 transmission, we passaged a modified HIV-1 in pigtailed macaques that were transiently depleted of CD8+ cells during acute infection. During adaptation over four passages in macaques, HIV-1 acquired the ability to antagonize the macaque restriction factor tetherin, replicated at progressively higher levels, and ultimately caused marked CD4+ T cell depletion and AIDS-defining conditions. Transient treatment with an antibody to CD8 during acute HIV-1 infection caused rapid progression to AIDS, whereas untreated animals exhibited an elite controller phenotype. Thus, an adapted HIV-1 can cause AIDS in macaques, and stark differences in outcome can be determined by immunological perturbations during early infection.</description><subject>Acquired immune deficiency syndrome</subject><subject>Acquired immunodeficiency syndrome</subject><subject>Acquired Immunodeficiency Syndrome - immunology</subject><subject>Acquired Immunodeficiency Syndrome - transmission</subject><subject>Acquired Immunodeficiency Syndrome - virology</subject><subject>AIDS</subject><subject>Amino Acid Sequence</subject><subject>Amino acids</subject><subject>Animals</subject><subject>Blood</subject><subject>Blood plasma</subject><subject>CD4-Positive T-Lymphocytes - immunology</subject><subject>CD8 Antigens - immunology</subject><subject>Depletion</subject><subject>Disease Models, Animal</subject><subject>Genes</subject><subject>HIV</subject><subject>HIV 1</subject><subject>HIV-1 - genetics</subject><subject>HIV-1 - physiology</subject><subject>Host-Pathogen Interactions - immunology</subject><subject>Human</subject><subject>Human immunodeficiency virus</subject><subject>Human immunodeficiency virus 1</subject><subject>Human Immunodeficiency Virus Proteins - chemistry</subject><subject>Human Immunodeficiency Virus Proteins - genetics</subject><subject>Human Immunodeficiency Virus Proteins - metabolism</subject><subject>Immunology</subject><subject>Infections</subject><subject>Lymphocyte Depletion</subject><subject>Macaca</subject><subject>Macaca nemestrina - immunology</subject><subject>Macaca nemestrina - virology</subject><subject>Molecular Sequence Data</subject><subject>Monkeys</subject><subject>Monkeys & apes</subject><subject>Mutation</subject><subject>Mutations</subject><subject>Pigtails</subject><subject>Protein Structure, Tertiary</subject><subject>Proteins</subject><subject>T lymphocytes</subject><subject>Viral Regulatory and Accessory Proteins - chemistry</subject><subject>Viral Regulatory and Accessory Proteins - genetics</subject><subject>Viral Regulatory and Accessory Proteins - metabolism</subject><subject>Viremia</subject><subject>Virology</subject><subject>Virus Replication</subject><issn>0036-8075</issn><issn>1095-9203</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkUtPwkAUhSdGI4iuXakkbtwU7p1nZ2NC8AEJiQsf20mZTrUIrXaoCTv_g__QX2IJlaArVndxvnuScw4hxwgdRCq73qYus66DVICSuEOaCFoEmgLbJU0AJoMQlGiQA-8nAJWm2T5pUK55qJhskrPB8CnA78-vNItL6-J2b3h1306z9izPXt3CH5K9JJp6d1TfFnm8uX7oD4LR3e2w3xsFVigxDygyjOOxFDiOtLTjWKATVGuZQGIlOOQqkSxhqGXIpFbgAFUcMS24o9oCa5HLle9bOZ652LpsXkRT81aks6hYmDxKzV8lS1_Mc_5hOJWSaVYZXNQGRf5eOj83s9RbN51GmctLbzCEEKlCtQUqBEoGXPAtUKa5YqEQFXr-D53kZZFVpS0pJRWEcpmzu6JskXtfuGQdEcEsJzX1pKaetPo43Wxmzf9uWAEnK2Di53mxoSvOFQL7AXfnpCA</recordid><startdate>20140620</startdate><enddate>20140620</enddate><creator>Hatziioannou, Theodora</creator><creator>Del Prete, Gregory Q.</creator><creator>Keele, Brandon F.</creator><creator>Estes, Jacob D.</creator><creator>McNatt, Matthew W.</creator><creator>Bitzegeio, Julia</creator><creator>Raymond, Alice</creator><creator>Rodriguez, Anthony</creator><creator>Schmidt, Fabian</creator><creator>Trubey, C. 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During adaptation over four passages in macaques, HIV-1 acquired the ability to antagonize the macaque restriction factor tetherin, replicated at progressively higher levels, and ultimately caused marked CD4+ T cell depletion and AIDS-defining conditions. Transient treatment with an antibody to CD8 during acute HIV-1 infection caused rapid progression to AIDS, whereas untreated animals exhibited an elite controller phenotype. Thus, an adapted HIV-1 can cause AIDS in macaques, and stark differences in outcome can be determined by immunological perturbations during early infection.</abstract><cop>United States</cop><pub>American Association for the Advancement of Science</pub><pmid>24948736</pmid><doi>10.1126/science.1250761</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Science (American Association for the Advancement of Science), 2014-06, Vol.344 (6190), p.1401-1405 |
| issn | 0036-8075 1095-9203 1095-9203 |
| language | eng |
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| source | MEDLINE; JSTOR Archive Collection A-Z Listing; American Association for the Advancement of Science |
| subjects | Acquired immune deficiency syndrome Acquired immunodeficiency syndrome Acquired Immunodeficiency Syndrome - immunology Acquired Immunodeficiency Syndrome - transmission Acquired Immunodeficiency Syndrome - virology AIDS Amino Acid Sequence Amino acids Animals Blood Blood plasma CD4-Positive T-Lymphocytes - immunology CD8 Antigens - immunology Depletion Disease Models, Animal Genes HIV HIV 1 HIV-1 - genetics HIV-1 - physiology Host-Pathogen Interactions - immunology Human Human immunodeficiency virus Human immunodeficiency virus 1 Human Immunodeficiency Virus Proteins - chemistry Human Immunodeficiency Virus Proteins - genetics Human Immunodeficiency Virus Proteins - metabolism Immunology Infections Lymphocyte Depletion Macaca Macaca nemestrina - immunology Macaca nemestrina - virology Molecular Sequence Data Monkeys Monkeys & apes Mutation Mutations Pigtails Protein Structure, Tertiary Proteins T lymphocytes Viral Regulatory and Accessory Proteins - chemistry Viral Regulatory and Accessory Proteins - genetics Viral Regulatory and Accessory Proteins - metabolism Viremia Virology Virus Replication |
| title | HIV-1–induced AIDS in monkeys |
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