Shear stress-triggered nitric oxide release from Schlemm's canal cells

Endothelial nitric oxide (NO) synthase is regulated by shear stress. At elevated intraocular pressures when the Schlemm's canal (SC) begins to collapse, shear stress is comparable with that in large arteries. We investigated the relationship between NO production and shear stress in cultured hu...

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Veröffentlicht in:	Investigative ophthalmology & visual science 2014-12, Vol.55 (12), p.8067-8076
Hauptverfasser:	Ashpole, Nicole E, Overby, Darryl R, Ethier, C Ross, Stamer, W Daniel
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Analysis of Variance Aqueous Humor - secretion Case-Control Studies Cells, Cultured Endothelial Cells - physiology Female Glaucoma - pathology Glaucoma - physiopathology Human Umbilical Vein Endothelial Cells Humans Intraocular Pressure - physiology Male Middle Aged Nitric Oxide - biosynthesis Nitric Oxide Synthase - metabolism Shear Strength Stress, Mechanical Trabecular Meshwork - cytology Trabecular Meshwork - physiology
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