Diagnostically untypable hepatitis C virus variants:It is time to resolve the problem
Pakistan is a low income country with more than 10million hepatitis C virus(HCV)infections and the burden is on continuous raise.Accurate viral genotyping is very critical for proper treatment of the infected individuals as the sustained virological response of the standard antiviral interferon ther...
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| Veröffentlicht in: | World journal of gastroenterology : WJG 2014-12, Vol.20 (46), p.17690-17692 |
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| container_issue | 46 |
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| container_title | World journal of gastroenterology : WJG |
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| creator | Afzal, Muhammad Sohail Khan, Muhammad Yousaf Ammar, Muhammad Anjum, Sadia Zaidi, Najm Us Sahar Sadaf |
| description | Pakistan is a low income country with more than 10million hepatitis C virus(HCV)infections and the burden is on continuous raise.Accurate viral genotyping is very critical for proper treatment of the infected individuals as the sustained virological response of the standard antiviral interferon therapy is genotype dependent.We observed at our diagnostic center that15.6%of HCV patient’s samples were not genotypeable by using Ohno et al method.The genotyped samples showed that 3a(68.3%)is the major prevalent genotype in Pakistan followed by 2a(10.3%),3b(2.6%),1b(1.5%),2b(1.2%)and 1a(0.5%).Presence of large number of untypable HCV variants in the current study highlights an important issue of health care setup in Pakistan.Untypable HCV cases create difficulties in treatment of these patients.The problem of routine diagnostics setup of Pakistan should be addressed on priority basis to facilitate the medical professionals in patient’s treatment and to help in achieving the maximum sustained virological response. |
| doi_str_mv | 10.3748/wjg.v20.i46.17690 |
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| source | MEDLINE; Baishideng "World Journal of" online journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Antiviral Agents - therapeutic use Developing Countries Diagnostics Genotype Genotypes Hepacivirus - genetics Hepatitis Hepatitis C - diagnosis Hepatitis C - drug therapy Hepatitis C - epidemiology Hepatitis C - virology Humans Letters To The Editor Molecular Diagnostic Techniques Pakistan - epidemiology Predictive Value of Tests Prevalence Prognosis Reproducibility of Results Untypable virus |
| title | Diagnostically untypable hepatitis C virus variants:It is time to resolve the problem |
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