Surface modifications of influenza proteins upon virus inactivation by β-propiolactone

Inactivation of intact influenza viruses using formaldehyde or β‐propiolactone (BPL) is essential for vaccine production and safety. The extent of chemical modifications of such reagents on viral proteins needs to be extensively investigated to better control the reactions and quality of vaccines. W...

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Veröffentlicht in:	Proteomics (Weinheim) 2013-12, Vol.13 (23-24), p.3537-3547
Hauptverfasser:	She, Yi-Min, Cheng, Keding, Farnsworth, Aaron, Li, Xuguang, Cyr, Terry D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Antigens, Viral - chemistry Biomedicine Cysteine - chemistry Hemagglutinins - chemistry Influenza vaccine Influenza Vaccines - chemistry Neuraminidase - chemistry Polysaccharides - chemistry Propiolactone - chemistry PTM RNA-Binding Proteins - chemistry Tandem Mass Spectrometry Viral Core Proteins - chemistry Viral Proteins - chemistry Virus Inactivation β-Propiolactone
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