Genomic landscape of Ewing sarcoma defines an aggressive subtype with co-association of STAG2 and TP53 mutations

Ewing sarcoma is a primary bone tumor initiated by EWSR1-ETS gene fusions. To identify secondary genetic lesions that contribute to tumor progression, we performed whole-genome sequencing of 112 Ewing sarcoma samples and matched germline DNA. Overall, Ewing sarcoma tumors had relatively few single-n...

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Veröffentlicht in:	Cancer discovery 2014-11, Vol.4 (11), p.1342-1353
Hauptverfasser:	Tirode, Franck, Surdez, Didier, Ma, Xiaotu, Parker, Matthew, Le Deley, Marie Cécile, Bahrami, Armita, Zhang, Zhaojie, Lapouble, Eve, Grossetête-Lalami, Sandrine, Rusch, Michael, Reynaud, Stéphanie, Rio-Frio, Thomas, Hedlund, Erin, Wu, Gang, Chen, Xiang, Pierron, Gaelle, Oberlin, Odile, Zaidi, Sakina, Lemmon, Gordon, Gupta, Pankaj, Vadodaria, Bhavin, Easton, John, Gut, Marta, Ding, Li, Mardis, Elaine R, Wilson, Richard K, Shurtleff, Sheila, Laurence, Valérie, Michon, Jean, Marec-Bérard, Perrine, Gut, Ivo, Downing, James, Dyer, Michael, Zhang, Jinghui, Delattre, Olivier
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, Nuclear - genetics Bone Neoplasms - genetics Cell Line, Tumor Cyclin-Dependent Kinase Inhibitor p16 - genetics DNA, Neoplasm - genetics Genomics Humans Mutation Prognosis Sarcoma, Ewing - genetics Sequence Analysis, DNA Tumor Suppressor Protein p53 - genetics
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